Bovine fibroblasts response to foot-and-mouth disease virus: influence of integrins and soluble factors in resistance
Artículo Fiebre Aftosa y Receptores
- Autores:
-
Ruiz Sáenz, Julián
Ossa, Jorge E.
Barrera, José
Rugeles, Maria Teresa
López Herrera, Albeiro
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2015
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/1297
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/1297
- Palabra clave:
- Virus
Fiebre Aftosa
Cattle
Virus receptors
Resistance
Infection
- Rights
- openAccess
- License
- Licencia CC
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Bovine fibroblasts response to foot-and-mouth disease virus: influence of integrins and soluble factors in resistance |
| title |
Bovine fibroblasts response to foot-and-mouth disease virus: influence of integrins and soluble factors in resistance |
| spellingShingle |
Bovine fibroblasts response to foot-and-mouth disease virus: influence of integrins and soluble factors in resistance Virus Fiebre Aftosa Cattle Virus receptors Resistance Infection |
| title_short |
Bovine fibroblasts response to foot-and-mouth disease virus: influence of integrins and soluble factors in resistance |
| title_full |
Bovine fibroblasts response to foot-and-mouth disease virus: influence of integrins and soluble factors in resistance |
| title_fullStr |
Bovine fibroblasts response to foot-and-mouth disease virus: influence of integrins and soluble factors in resistance |
| title_full_unstemmed |
Bovine fibroblasts response to foot-and-mouth disease virus: influence of integrins and soluble factors in resistance |
| title_sort |
Bovine fibroblasts response to foot-and-mouth disease virus: influence of integrins and soluble factors in resistance |
| dc.creator.fl_str_mv |
Ruiz Sáenz, Julián Ossa, Jorge E. Barrera, José Rugeles, Maria Teresa López Herrera, Albeiro |
| dc.contributor.author.none.fl_str_mv |
Ruiz Sáenz, Julián Ossa, Jorge E. Barrera, José Rugeles, Maria Teresa López Herrera, Albeiro |
| dc.subject.spa.fl_str_mv |
Virus Fiebre Aftosa Cattle Virus receptors Resistance Infection |
| topic |
Virus Fiebre Aftosa Cattle Virus receptors Resistance Infection |
| description |
Artículo Fiebre Aftosa y Receptores |
| publishDate |
2015 |
| dc.date.issued.none.fl_str_mv |
2015-02 |
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2017-08-23T15:48:49Z |
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2017-08-23T15:48:49Z |
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Ruiz Sáenz, J., Ossa, J., Barrera, J., Rugeles, M. T., & López Herrera, M. T. (2015). Bovine Fibroblasts Response to Foot-and-Mouth Disease Virus: Influence of Integrins and Soluble Factors in Resistance. Veterinar Sci Technolo, 6(2), doi.org/10.4172/2157-7579.1000219 |
| url |
https://hdl.handle.net/20.500.12494/1297 |
| identifier_str_mv |
Ruiz Sáenz, J., Ossa, J., Barrera, J., Rugeles, M. T., & López Herrera, M. T. (2015). Bovine Fibroblasts Response to Foot-and-Mouth Disease Virus: Influence of Integrins and Soluble Factors in Resistance. Veterinar Sci Technolo, 6(2), doi.org/10.4172/2157-7579.1000219 |
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https://www.omicsonline.org/open-access/bovine-fibroblasts-response-to-footandmouth-disease-virus-influence-of-integrins-and-soluble-factors-in-resistance-2157-7579.1000219.php?aid=40756 |
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Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina Veterinaría y Zootecnia, Bucaramanga, Colombia, 00000 |
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Medicina veterinaria y zootecnia |
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Bucaramanga |
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Universidad Cooperativa de Colombia |
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Ruiz Sáenz, Julián Ossa, Jorge E.Barrera, JoséRugeles, Maria TeresaLópez Herrera, Albeiro2017-08-23T15:48:49Z2017-08-23T15:48:49Z2015-02https://hdl.handle.net/20.500.12494/1297Ruiz Sáenz, J., Ossa, J., Barrera, J., Rugeles, M. T., & López Herrera, M. T. (2015). Bovine Fibroblasts Response to Foot-and-Mouth Disease Virus: Influence of Integrins and Soluble Factors in Resistance. Veterinar Sci Technolo, 6(2), doi.org/10.4172/2157-7579.1000219Artículo Fiebre Aftosa y ReceptoresFoot and mouth disease may be the most economically devastating animal disease nowadays. Blanco Orejinegro (BON) cattle are one of the native creole breeds from Colombia; this breed carries important genetic traits for survival and reproduction in the tropics showing in vitro and in vivo resistance to pathogens. Here we evaluate primary fibroblast cultures of BON cattle for their phenotypic resistence/susceptibility (R/S) polymorphism toward FMDV, and to determine whether a correlation exists between the R/S polymorphism and expression of integrin αV-β3, and/ or the antiviral activity in the supernatants of those cultures. Our data show that different R/S patterns to FMDV in vitro. Between 2% and 85% of the fibroblasts in the PCF-BON samples expressed integrin aV-b3. Interestingly, a correlation between R/S and expression of this receptor was observed for the A24 FMDV subtype. Highly resistant cultures showed a low level of integrin expression. Furthermore a correlation was observed between resistance and antiviral activity (AVA) of supernatants from infected samples. Supernatants with high AVA were always from very resistant samples for subtype A24, or from very resistant or resistant samples for subtype O1; supernatants with low AVA were from susceptible samples. In most samples, the factor in the supernatants responsible for AVA was not only resistant to heating, but AVA increases after heating. To our knowledge, this is the first report showing resistance to FMDV infection in vitro using primary cultures from bovines.julian.ruizs@ucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina Veterinaría y Zootecnia, Bucaramanga, Colombia, 00000Medicina veterinaria y zootecniaBucaramangahttps://www.omicsonline.org/open-access/bovine-fibroblasts-response-to-footandmouth-disease-virus-influence-of-integrins-and-soluble-factors-in-resistance-2157-7579.1000219.php?aid=40756VirusFiebre AftosaCattleVirus receptorsResistanceInfectionBovine fibroblasts response to foot-and-mouth disease virus: influence of integrins and soluble factors in resistanceArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia 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