Preferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method
Artículo de investigación
- Autores:
-
Peña, María A.
Delgado, Daniel Ricardo
Martínez, Fleming
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2015
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/1047
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/1047
- Palabra clave:
- Indomethacin; 1-dioxane; solubility; inverse Kirkwood– Buff integrals; IKBI; preferential solvation
- Rights
- closedAccess
- License
- Licencia CC
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| dc.title.spa.fl_str_mv |
Preferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method |
| title |
Preferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method |
| spellingShingle |
Preferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method Indomethacin; 1-dioxane; solubility; inverse Kirkwood– Buff integrals; IKBI; preferential solvation |
| title_short |
Preferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method |
| title_full |
Preferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method |
| title_fullStr |
Preferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method |
| title_full_unstemmed |
Preferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method |
| title_sort |
Preferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method |
| dc.creator.fl_str_mv |
Peña, María A. Delgado, Daniel Ricardo Martínez, Fleming |
| dc.contributor.advisor.none.fl_str_mv |
Delgado, Daniel Ricardo |
| dc.contributor.author.none.fl_str_mv |
Peña, María A. Delgado, Daniel Ricardo Martínez, Fleming |
| dc.subject.spa.fl_str_mv |
Indomethacin; 1-dioxane; solubility; inverse Kirkwood– Buff integrals; IKBI; preferential solvation |
| topic |
Indomethacin; 1-dioxane; solubility; inverse Kirkwood– Buff integrals; IKBI; preferential solvation |
| description |
Artículo de investigación |
| publishDate |
2015 |
| dc.date.issued.none.fl_str_mv |
2015-11-23 |
| dc.date.accessioned.none.fl_str_mv |
2017-08-10T20:55:58Z |
| dc.date.available.none.fl_str_mv |
2017-08-10T20:55:58Z |
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Artículo |
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https://hdl.handle.net/20.500.12494/1047 |
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María Á. Peña, Daniel R. Delgado & Fleming Martínez (2016) Preferential solvation of indomethacin in 1,4-dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method, Physics and Chemistry of Liquids, 54:4, 462-474, DOI: 10.1080/00319104.2015.1115329 |
| url |
https://hdl.handle.net/20.500.12494/1047 |
| identifier_str_mv |
María Á. Peña, Daniel R. Delgado & Fleming Martínez (2016) Preferential solvation of indomethacin in 1,4-dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method, Physics and Chemistry of Liquids, 54:4, 462-474, DOI: 10.1080/00319104.2015.1115329 |
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http://www.tandfonline.com/doi/full/10.1080/00319104.2015.1115329 |
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Licencia CC |
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Universidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000 |
| dc.publisher.program.spa.fl_str_mv |
Ingeniería Industrial |
| dc.publisher.place.spa.fl_str_mv |
Neiva |
| institution |
Universidad Cooperativa de Colombia |
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Delgado, Daniel RicardoPeña, María A.Delgado, Daniel RicardoMartínez, Fleming2017-08-10T20:55:58Z2017-08-10T20:55:58Z2015-11-23https://hdl.handle.net/20.500.12494/1047María Á. Peña, Daniel R. Delgado & Fleming Martínez (2016) Preferential solvation of indomethacin in 1,4-dioxane + water mixtures according to the inverse Kirkwood–Buff integrals method, Physics and Chemistry of Liquids, 54:4, 462-474, DOI: 10.1080/00319104.2015.1115329Artículo de investigaciónThe preferential solvation parameters (δx1,3) of indomethacin (IMC) in 1,4-dioxane + water binary mixtures were derived from their thermo- dynamic properties by means of the inverse Kirkwood–Buff integrals method. δx1,3 is negative in water-rich and 1,4-dioxane-rich mixtures but positive in cosolvent compositions from 0.17 to 0.69 in mole fraction of 1,4-dioxane at 298.15 K. It is conjecturable that in water-rich mixtures, the hydrophobic hydration around the aromatic and methyl groups of the drug plays a relevant role in the solvation. The higher solvation by 1,4-dioxane in mixtures of similar cosolvent compositions could be mainly due to polarity effects. Finally, the preference of this drug for water in 1,4-dioxane-rich mixtures could be explained in terms of the higher acidic behavior of water molecules interacting with the hydrogen- acceptor groups present in IMC.Introduction, Theoretical, Results and discussion, Conclusions, Referencesdanielr.delgado@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ingenierías, Programa de Ingeniería Industrial, Neiva, Colombia, 00000Ingeniería IndustrialNeivahttp://www.tandfonline.com/doi/full/10.1080/00319104.2015.1115329Indomethacin; 1-dioxane; solubility; inverse Kirkwood– Buff integrals; IKBI; preferential solvationPreferential solvation of indomethacin in 1,4- dioxane + water mixtures according to the inverse Kirkwood–Buff integrals methodArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia 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