Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina

La endometritis es una inflamación interna del útero, propia del endometrio, el cual es colonizado por bacterias que son causales de muchas enfermedades de tipo reproductivo en equinos.(1) Los principales signos clínicos consisten en desordenes reproductivos tales como: repetición de celos, anestro...

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Autores:
Vargas Naranjo, Heidy Camila
Tipo de recurso:
Trabajo de grado de pregrado
Fecha de publicación:
2024
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
spa
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/56838
Acceso en línea:
https://hdl.handle.net/20.500.12494/56838
Palabra clave:
Endometritis
Infertilidad
Tratamiento
Antibiotico
Yeguas
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openAccess
License
http://creativecommons.org/licenses/by-nc-sa/4.0/
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dc.title.spa.fl_str_mv Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina
title Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina
spellingShingle Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina
Endometritis
Infertilidad
Tratamiento
Antibiotico
Yeguas
title_short Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina
title_full Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina
title_fullStr Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina
title_full_unstemmed Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina
title_sort Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina
dc.creator.fl_str_mv Vargas Naranjo, Heidy Camila
dc.contributor.advisor.none.fl_str_mv Bonilla Izquierdo, Alexander
dc.contributor.author.none.fl_str_mv Vargas Naranjo, Heidy Camila
dc.subject.proposal.none.fl_str_mv Endometritis
Infertilidad
Tratamiento
Antibiotico
Yeguas
topic Endometritis
Infertilidad
Tratamiento
Antibiotico
Yeguas
description La endometritis es una inflamación interna del útero, propia del endometrio, el cual es colonizado por bacterias que son causales de muchas enfermedades de tipo reproductivo en equinos.(1) Los principales signos clínicos consisten en desordenes reproductivos tales como: repetición de celos, anestro (no presencia de celo), aumento en el número de servicios por concepción, ciclo reproductivo irregular, entre otros. Teniendo en cuenta lo anterior, la endometritis bacteriana en la yegua, es considerada como la causa más común de infertilidad, por lo cual adquiere importancia en el manejo reproductivo y sanitario, debido al impacto económico que puede representar para la producción equina. (2) Generalmente los tratamientos antibióticos suelen fracasar aumentando los casos de infertilidad en las hembras.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2024-08-08T18:16:59Z
dc.date.available.none.fl_str_mv 2024-08-08T18:16:59Z
dc.date.issued.none.fl_str_mv 2024-08-08
dc.type.none.fl_str_mv Trabajo de grado - Pregrado
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dc.type.content.none.fl_str_mv Text
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dc.identifier.citation.none.fl_str_mv Vargas Naranjo, H. C. (2024). Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional Universidad Cooperativa de Colombia. https://hdl.handle.net/20.500.12494/56838
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/56838
identifier_str_mv Vargas Naranjo, H. C. (2024). Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional Universidad Cooperativa de Colombia. https://hdl.handle.net/20.500.12494/56838
url https://hdl.handle.net/20.500.12494/56838
dc.language.iso.none.fl_str_mv spa
language spa
dc.relation.references.none.fl_str_mv Gallego RS, Johana K, Quintero V, Vanesa T, Henao M. DESCRIPCIÓN DIAGNÓSTICA DE LA ENDOMETRITIS AGUDA EN YEGUAS. Revista Sinergia. 2018;2:25-37.
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercialCompartirIgual 4.0 Internacional. REVISIÓN DE LITERATURA SOBRE DIAGNÓSTICO Y TRATAMIENTO DE ENDOMETRITIS EQUINA CAMILO ANDRÉS VIDALES RUBIO LAURA GÓMEZ OSPINA UNIVERSIDAD COOPERATIVA DE COLOMBIA FACULTAD DE MEDICINA VETERINARIA Y ZOOTECNIA.
Harol A, Buitrago D, Id A, María T, Pilar D, Bonilla S. ENDOMETRITIS EN YEGUAS, PRINCIPALES CAUSAS Y MÉTODOS DIAGNÓSTICOS POR LABORATORIO: REVISIÓN SISTEMÁTICA ENDOMETRITIS IN MARES, MAIN CAUSES AND METHODS DIAGNOSTICS BY LABORATORY: SYSTEMATIC REVIEW. 2023.
Da Silva-Álvarez E, Gómez-Arrones V, Martín-Cano FE, Gaitskell-Phillips G, OrtizRodríguez JM, Carrasco JJ, et al. Endometrial area of the blood flow as a marker of endometritis in equine. Reproduction in Domestic Animals. 1 de octubre de 2022;57(S5):98-102.
Walter J, Neuberg KP, Failing K, Wehrend A. Cytological diagnosis of endometritis in the mare: Investigations of sampling techniques and relation to bacteriological results. Anim Reprod Sci. junio de 2012;132(3-4):178-86.
Carnota Martínez S. Facultad de Veterinaria Fin de Grado.
Lüttgenau J, Imboden I, Wellnitz O, Romer R, Scaravaggi I, Neves AP, et al. Intrauterine infusion of killed semen adversely affects uterine blood flow and endometrial gene expression of inflammatory cytokines in mares susceptible to persistent breeding-induced endometritis. Theriogenology. 15 de marzo de 2021;163:18-30
Morrell JM, Rocha A. A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State. Front Vet Sci. 6 de enero de 2022;8.
Heil BA, van Heule M, Thompson SK, Kearns TA, Oberhaus EL, King G, et al. Effect of Sampling Method on Detection of the Equine Uterine Microbiome during Estrus. Vet Sci. 8 de noviembre de 2023;10(11):644.
Segabinazzi LGTM, Podico G, Rosser MF, Nanjappa SG, Alvarenga MA, Canisso IF. Three manual noncommercial methods to prepare equine platelet-rich plasma. Animals. 1 de junio de 2021;11(6).
Ortega-Ferrusola C, Gómez-Arrones V, Martín-Cano FE, Gil MC, Peña FJ, GaitskellPhillips G, et al. Advances in the ultrasound diagnosis in equine reproductive medicine: New approaches. Vol. 57, Reproduction in Domestic Animals. John Wiley and Sons Inc; 2022. p. 34-44.
Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent breeding-induced endometritis in mares - a multifaceted challenge: From clinical aspects to immunopathogenesis and pathobiology. Vol. 21, International Journal of Molecular Sciences. MDPI AG; 2020.
Segabinazzi LGTM, Canisso IF, Podico G, Cunha LL, Novello G, Rosser MF, et al. Intrauterine blood plasma platelet-therapy mitigates persistent breeding-induced endometritis, reduces uterine infections, and improves embryo recovery in Mares. Antibiotics. 1 de mayo de 2021;10(5).
Schöniger S, Schoon HA. The healthy and diseased equine endometrium: A review of morphological features and molecular analyses. Vol. 10, Animals. MDPI AG; 2020.
Katila T, Segabinazzi L, Maldonado-Estrada JG, Köhne M. Comparison of systemic trimethoprim-sulfadimethoxine treatment and intrauterine ozone application as possible therapies for bacterial endometritis in equine practice.
A Morris LH, McCue PM, Aurich C. Equine endometritis: a review of challenges and new approaches. 2020;
Díaz‐bertrana ML, Deleuze S, Rios LP, Yeste M, Fariña IM, Del Alamo MMR. Microbial prevalence and antimicrobial sensitivity in equine endometritis in field conditions. Animals. 1 de mayo de 2021;11(5).
Rantala M, Attia S, Koukila-Kähkölä P, De Hoog S, Anttila M, Katila T. Cladophialophora bantiana as an emerging pathogen in animals: Case report of equine endometritis and review of the literature. Vol. 53, Journal of Clinical Microbiology. American Society for Microbiology; 2015. p. 3047-53.
Ibrahim S, Hedia M, Taqi MO, Derbala MK, Mahmoud KGM, Ahmed Y, et al. Extracellular vesicles in low volume uterine lavage and serum: novel and promising biomarker for endometritis in Arabian mares. BMC Vet Res. 1 de diciembre de 2022;18(1).
Parrilla Hernández S, Franck T, Munaut C, Feyereisen É, Piret J, Farnir F, et al. Characterization of Myeloperoxidase in the Healthy Equine Endometrium. Animals. 1 de febrero de 2023;13(3).
Marth CD, Firestone SM, Glenton LY, Browning GF, Young ND, Krekeler N. Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis. Vet Res. 8 de noviembre de 2016;47(1):1-17.
Sikora M, Król J, Nowak M, Stefaniak T, Aubertsson G, Kozdrowski R. The usefulness of uterine lavage and acute phase protein levels as a diagnostic tool for subclinical endometritis in Icelandic mares. Acta Vet Scand. 7 de septiembre de 2016;58(1).
Köhne M, Kuhlmann M, Tönißen A, Martinsson G, Sieme H. Diagnostic and Treatment Practices of Equine Endometritis—A Questionnaire. Front Vet Sci. 2 de septiembre de 2020;7.
Scarlet D, Malama E, Fischer S, Knutti B, Bollwein H. Relationship between Clinical Uterine Findings, Therapy, and Fertility in the Mare. Vet Sci. 1 de abril de 2023;10(4).
Rasmussen CD, Haugaard MM, Petersen MR, Nielsen JM, Pedersen HG, Bojesen AM. Streptococcus equi subsp. zooepidemicus isolates from equine infectious endometritis belong to a distinct genetic group [Internet]. 2013. Disponible en: http://www.veterinaryresearch.org/content/44/1/26
Amaral A, Fernandes C, Rebordão MR, Szóstek-Mioduchowska A, Lukasik K, Gawronska-Kozak B, et al. The in vitro inhibitory effect of sivelestat on elastase induced collagen and metallopeptidase expression in equine endometrium. Animals. 1 de mayo de 2020;10(5).
Arlas TR, Wolf CA, Petrucci BPL, Estanislau JF, Gregory RM, Jobim MIM, et al. Proteomics of endometrial fluid after dexamethasone treatment in mares susceptible to endometritis. Theriogenology. 1 de septiembre de 2015;84(4):617-23.
Parrilla-Hernandez S, Ponthier JÔ, Franck TY, Serteyn DD, Deleuze SC. High concentrations of myeloperoxidase in the equine uterus as an indicator of endometritis. Theriogenology. 15 de abril de 2014;81(7):936-40.
Marcos R, Ribeiro T, Santos M, Correia-Gomes C, Guimarães T, Blielbernicht M, et al. The advantages of using cytospins of uterine lavage fluid for the diagnosis of Running title: Cytospins in uterine lavage Institute of Biomedical Sciences Abel Salazar-ICBAS. Vol. 228.
Saqib M, Salman Waqas M, Umer S, Zhang Y. Construction of a model of endometritis in domestic rabbits using equine-derived pathogens and evaluation of therapeutic effect of sensitive drugs.
Tyrnenopoulou P, Fthenakis GC. Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids. Vol. 12, Antibiotics. MDPI; 2023.
da Piedade I, Skive B, Christensen H, Bojesen AM. Draft Genome Sequence of Streptococcus equi subsp. zooepidemicus Strain S31A1, Isolated from Equine Infectious Endometritis . Genome Announc.
de octubre de 2013;1(5). 33. Anzai T, Kamada M, Niwa H, Eguchi M, Nishi H. Contagious equine metritis eradicated from Japan. Vol. 74, Journal of Veterinary Medical Science. 2012. p. 51922.
Tukia E, Hallman I, Penttilä M, Hänninen S, Kareskoski M. RNA in situ hybridization of Escherichia coli in equine endometrial biopsies. Front Vet Sci. 2023;10.
Carluccio A, Veronesi MC, Plenteda D, Mazzatenta A. Platelet-rich plasma uterine infusion and pregnancy rate in barren mares with chronic degenerative endometritis. Pol J Vet Sci. 2020;23(3):431-8.
Bazzano M, Marchegiani A, Troisi A, McLean A, Laus F. Serum Amyloid A as a Promising Biomarker in Domestic Animals’ Reproduction: Current Knowledge and Future Perspective. Vol. 12, Animals. MDPI; 2022.
Jasiński T, Zdrojkowski Ł, Kautz E, Juszczuk-Kubiak E, Ferreira-Dias G, Domino M. The NF-κB-signalling pathway in mare’s endometrium infiltrated with the inflammatory cells. Reproduction in Domestic Animals. 1 de junio de 2022;57(6):598610.
Ferris RA, McCue PM, Borlee GI, Loncar KD, Hennet ML, Borlee BR. In Vitro Efficacy of Nonantibiotic Treatments on Biofilm Disruption of Gram-Negative Pathogens and an in Vivo Model of Infectious Endometritis Utilizing Isolates from the Equine Uterus. J Clin Microbiol. 1 de marzo de 2016;54(3):631-9.
Siemieniuch MJ, Szóstek AZ, Gajos K, Kozdrowski R, Nowak M, Okuda K. Type of inflammation differentially affects expression of interleukin 1β and 6, tumor necrosis factor-α and toll-like receptors in subclinical endometritis in mares. PLoS One. 1 de mayo de 2016;11(5).
Ibrahim S, Hedia M, Taqi MO, Derbala MK, Mahmoud KGM, Ahmed Y, et al. Extracellular vesicles in low volume uterine lavage and serum: novel and promising biomarker for endometritis in Arabian mares. BMC Vet Res. 1 de diciembre de 2022;18(1).
Lange-Consiglio A, Gaspari G, Funghi F, Capra E, Cretich M, Frigerio R, et al. Amniotic Mesenchymal-Derived Extracellular Vesicles and Their Role in the Prevention of Persistent Post-Breeding Induced Endometritis. Int J Mol Sci. 1 de marzo de 2023;24(6).
Ferris RA, Mccue PM, Borlee GI, Glapa KE, Martin KH, Mangalea MR, et al. Model of Chronic Equine Endometritis Involving a Pseudomonas aeruginosa Biofilm. 2017; Disponible en: https://doi.org/10.1128/IAI
A Morris LH, McCue PM, Aurich C. Equine endometritis: a review of challenges and new approaches. 2020.
Garner C, Stephen C, Pant SD, Ghorashi SA. Comparison of PCR-HRM, colorimetric LAMP and culture based diagnostic assays in the detection of endometritis caused by Streptococcus equi subsp. zooepidemicus in mares. Vet Res Commun. 1 de junio de 2023;47(2):495-509.
Buczkowska J, Kozdrowski R, Nowak M, Raś A, Staroniewicz Z, Siemieniuch MJ. Comparison of the biopsy and cytobrush techniques for diagnosis of subclinical endometritis in mares. Reproductive Biology and Endocrinology. 4 de abril de 2014;12(1).
Ibrahim S, Hedia M, Taqi MO, Derbala MK, Mahmoud KGM, Ahmed Y, et al. Alterations in the expression profile of serum mir-155, mir-223, mir-17, mir-200a, mir-205, as well as levels of interleukin 6, and prostaglandins during endometritis in arabian mares. Vet Sci. 1 de junio de 2021;8(6).
Monteiro de Barros MR, Davies-Morel MCG, Mur LAJ, Creevey CJ, Alison RH, Nash DM. Characterization of an ex vivo equine endometrial tissue culture model using next-generation rna-sequencing technology. Animals. 1 de julio de 2021;11(7).
Agerholm JS. Coxiella burnetii associated reproductive disorders in domestic animalsa critical review [Internet]. 2013. Disponible en: http://www.actavetscand.com/content/55/1/13
Wolf CA, Maslchitzky E, Gregory RM, Jobim MIM, Mattos RC. Effect of corticotherapy on proteomics of endometrial fluid from mares susceptible to persistent postbreeding endometritis. Theriogenology. 15 de abril de 2012;77(7):1351-9.
Lara E, Rivera N, Cabezas J, Navarrete F, Saravia F, Rodríguez-Alvarez L, et al. Endometrial stem cells in farm animals: Potential role in uterine physiology and pathology. Vol. 5, Bioengineering. MDPI AG; 2018.
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spelling Bonilla Izquierdo, AlexanderVargas Naranjo, Heidy Camila2024-08-08T18:16:59Z2024-08-08T18:16:59Z2024-08-08Vargas Naranjo, H. C. (2024). Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equina. [Tesis de pregrado, Universidad Cooperativa de Colombia]. Repositorio Institucional Universidad Cooperativa de Colombia. https://hdl.handle.net/20.500.12494/56838https://hdl.handle.net/20.500.12494/56838La endometritis es una inflamación interna del útero, propia del endometrio, el cual es colonizado por bacterias que son causales de muchas enfermedades de tipo reproductivo en equinos.(1) Los principales signos clínicos consisten en desordenes reproductivos tales como: repetición de celos, anestro (no presencia de celo), aumento en el número de servicios por concepción, ciclo reproductivo irregular, entre otros. Teniendo en cuenta lo anterior, la endometritis bacteriana en la yegua, es considerada como la causa más común de infertilidad, por lo cual adquiere importancia en el manejo reproductivo y sanitario, debido al impacto económico que puede representar para la producción equina. (2) Generalmente los tratamientos antibióticos suelen fracasar aumentando los casos de infertilidad en las hembras.1. Resumen. -- 2. Abstract. -- 3. Introducción. -- 4. Clasificación de la Endometritis. -- 5. Endometritis Aguda. -- 6. Endometriosis. -- 7. Endometritis Infectiva Crónica. -- 8. Etiología. -- 9. Agentes causales. -- 10. Endometritis Bacterianas. -- 11. Endometritis Fúngicas. -- 12. Mecanismos de transmisión. -- 13. Signos Clínicos . -- 14. Diagnóstico. -- 15. Exámen Clínico . -- 16. Laboratorio. -- 17. Espéculo vaginal. -- 18. Imagenología.-- 19. Citología Veterinaria. -- 20. Cultivo y antibiograma. -- 21. Tratamiento para Endometritis Equina. -- 30. Referencias Bibliográficas.PregradoMedico Veterinario29 p.application/pdfspaUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina Veterinaría y Zootecnia, IbaguéMedicina veterinaria y zootecniaCiencias de la SaludIbaguéIbaguéhttp://creativecommons.org/licenses/by-nc-sa/4.0/info:eu-repo/semantics/openAccessAttribution-NonCommercial-ShareAlike 4.0 Internationalhttp://purl.org/coar/access_right/c_abf2Análisis sistemático de literatura sobre actualización de tratamientos empleados en endometritis equinaTrabajo de grado - Pregradohttp://purl.org/coar/resource_type/c_7a1fTextinfo:eu-repo/semantics/bachelorThesishttp://purl.org/redcol/resource_type/TPinfo:eu-repo/semantics/acceptedVersionGallego RS, Johana K, Quintero V, Vanesa T, Henao M. DESCRIPCIÓN DIAGNÓSTICA DE LA ENDOMETRITIS AGUDA EN YEGUAS. Revista Sinergia. 2018;2:25-37.Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercialCompartirIgual 4.0 Internacional. REVISIÓN DE LITERATURA SOBRE DIAGNÓSTICO Y TRATAMIENTO DE ENDOMETRITIS EQUINA CAMILO ANDRÉS VIDALES RUBIO LAURA GÓMEZ OSPINA UNIVERSIDAD COOPERATIVA DE COLOMBIA FACULTAD DE MEDICINA VETERINARIA Y ZOOTECNIA.Harol A, Buitrago D, Id A, María T, Pilar D, Bonilla S. ENDOMETRITIS EN YEGUAS, PRINCIPALES CAUSAS Y MÉTODOS DIAGNÓSTICOS POR LABORATORIO: REVISIÓN SISTEMÁTICA ENDOMETRITIS IN MARES, MAIN CAUSES AND METHODS DIAGNOSTICS BY LABORATORY: SYSTEMATIC REVIEW. 2023.Da Silva-Álvarez E, Gómez-Arrones V, Martín-Cano FE, Gaitskell-Phillips G, OrtizRodríguez JM, Carrasco JJ, et al. Endometrial area of the blood flow as a marker of endometritis in equine. Reproduction in Domestic Animals. 1 de octubre de 2022;57(S5):98-102.Walter J, Neuberg KP, Failing K, Wehrend A. Cytological diagnosis of endometritis in the mare: Investigations of sampling techniques and relation to bacteriological results. Anim Reprod Sci. junio de 2012;132(3-4):178-86.Carnota Martínez S. Facultad de Veterinaria Fin de Grado.Lüttgenau J, Imboden I, Wellnitz O, Romer R, Scaravaggi I, Neves AP, et al. Intrauterine infusion of killed semen adversely affects uterine blood flow and endometrial gene expression of inflammatory cytokines in mares susceptible to persistent breeding-induced endometritis. Theriogenology. 15 de marzo de 2021;163:18-30Morrell JM, Rocha A. A Novel Approach to Minimising Acute Equine Endometritis That May Help to Prevent the Development of the Chronic State. Front Vet Sci. 6 de enero de 2022;8.Heil BA, van Heule M, Thompson SK, Kearns TA, Oberhaus EL, King G, et al. Effect of Sampling Method on Detection of the Equine Uterine Microbiome during Estrus. Vet Sci. 8 de noviembre de 2023;10(11):644.Segabinazzi LGTM, Podico G, Rosser MF, Nanjappa SG, Alvarenga MA, Canisso IF. Three manual noncommercial methods to prepare equine platelet-rich plasma. Animals. 1 de junio de 2021;11(6).Ortega-Ferrusola C, Gómez-Arrones V, Martín-Cano FE, Gil MC, Peña FJ, GaitskellPhillips G, et al. Advances in the ultrasound diagnosis in equine reproductive medicine: New approaches. Vol. 57, Reproduction in Domestic Animals. John Wiley and Sons Inc; 2022. p. 34-44.Canisso IF, Segabinazzi LGTM, Fedorka CE. Persistent breeding-induced endometritis in mares - a multifaceted challenge: From clinical aspects to immunopathogenesis and pathobiology. Vol. 21, International Journal of Molecular Sciences. MDPI AG; 2020.Segabinazzi LGTM, Canisso IF, Podico G, Cunha LL, Novello G, Rosser MF, et al. Intrauterine blood plasma platelet-therapy mitigates persistent breeding-induced endometritis, reduces uterine infections, and improves embryo recovery in Mares. Antibiotics. 1 de mayo de 2021;10(5).Schöniger S, Schoon HA. The healthy and diseased equine endometrium: A review of morphological features and molecular analyses. Vol. 10, Animals. MDPI AG; 2020.Katila T, Segabinazzi L, Maldonado-Estrada JG, Köhne M. Comparison of systemic trimethoprim-sulfadimethoxine treatment and intrauterine ozone application as possible therapies for bacterial endometritis in equine practice.A Morris LH, McCue PM, Aurich C. Equine endometritis: a review of challenges and new approaches. 2020;Díaz‐bertrana ML, Deleuze S, Rios LP, Yeste M, Fariña IM, Del Alamo MMR. Microbial prevalence and antimicrobial sensitivity in equine endometritis in field conditions. Animals. 1 de mayo de 2021;11(5).Rantala M, Attia S, Koukila-Kähkölä P, De Hoog S, Anttila M, Katila T. Cladophialophora bantiana as an emerging pathogen in animals: Case report of equine endometritis and review of the literature. Vol. 53, Journal of Clinical Microbiology. American Society for Microbiology; 2015. p. 3047-53.Ibrahim S, Hedia M, Taqi MO, Derbala MK, Mahmoud KGM, Ahmed Y, et al. Extracellular vesicles in low volume uterine lavage and serum: novel and promising biomarker for endometritis in Arabian mares. BMC Vet Res. 1 de diciembre de 2022;18(1).Parrilla Hernández S, Franck T, Munaut C, Feyereisen É, Piret J, Farnir F, et al. Characterization of Myeloperoxidase in the Healthy Equine Endometrium. Animals. 1 de febrero de 2023;13(3).Marth CD, Firestone SM, Glenton LY, Browning GF, Young ND, Krekeler N. Oestrous cycle-dependent equine uterine immune response to induced infectious endometritis. Vet Res. 8 de noviembre de 2016;47(1):1-17.Sikora M, Król J, Nowak M, Stefaniak T, Aubertsson G, Kozdrowski R. The usefulness of uterine lavage and acute phase protein levels as a diagnostic tool for subclinical endometritis in Icelandic mares. Acta Vet Scand. 7 de septiembre de 2016;58(1).Köhne M, Kuhlmann M, Tönißen A, Martinsson G, Sieme H. Diagnostic and Treatment Practices of Equine Endometritis—A Questionnaire. Front Vet Sci. 2 de septiembre de 2020;7.Scarlet D, Malama E, Fischer S, Knutti B, Bollwein H. Relationship between Clinical Uterine Findings, Therapy, and Fertility in the Mare. Vet Sci. 1 de abril de 2023;10(4).Rasmussen CD, Haugaard MM, Petersen MR, Nielsen JM, Pedersen HG, Bojesen AM. Streptococcus equi subsp. zooepidemicus isolates from equine infectious endometritis belong to a distinct genetic group [Internet]. 2013. Disponible en: http://www.veterinaryresearch.org/content/44/1/26Amaral A, Fernandes C, Rebordão MR, Szóstek-Mioduchowska A, Lukasik K, Gawronska-Kozak B, et al. The in vitro inhibitory effect of sivelestat on elastase induced collagen and metallopeptidase expression in equine endometrium. Animals. 1 de mayo de 2020;10(5).Arlas TR, Wolf CA, Petrucci BPL, Estanislau JF, Gregory RM, Jobim MIM, et al. Proteomics of endometrial fluid after dexamethasone treatment in mares susceptible to endometritis. Theriogenology. 1 de septiembre de 2015;84(4):617-23.Parrilla-Hernandez S, Ponthier JÔ, Franck TY, Serteyn DD, Deleuze SC. High concentrations of myeloperoxidase in the equine uterus as an indicator of endometritis. Theriogenology. 15 de abril de 2014;81(7):936-40.Marcos R, Ribeiro T, Santos M, Correia-Gomes C, Guimarães T, Blielbernicht M, et al. The advantages of using cytospins of uterine lavage fluid for the diagnosis of Running title: Cytospins in uterine lavage Institute of Biomedical Sciences Abel Salazar-ICBAS. Vol. 228.Saqib M, Salman Waqas M, Umer S, Zhang Y. Construction of a model of endometritis in domestic rabbits using equine-derived pathogens and evaluation of therapeutic effect of sensitive drugs.Tyrnenopoulou P, Fthenakis GC. Clinical Aspects of Bacterial Distribution and Antibiotic Resistance in the Reproductive System of Equids. Vol. 12, Antibiotics. MDPI; 2023.da Piedade I, Skive B, Christensen H, Bojesen AM. Draft Genome Sequence of Streptococcus equi subsp. zooepidemicus Strain S31A1, Isolated from Equine Infectious Endometritis . Genome Announc.de octubre de 2013;1(5). 33. Anzai T, Kamada M, Niwa H, Eguchi M, Nishi H. Contagious equine metritis eradicated from Japan. Vol. 74, Journal of Veterinary Medical Science. 2012. p. 51922.Tukia E, Hallman I, Penttilä M, Hänninen S, Kareskoski M. RNA in situ hybridization of Escherichia coli in equine endometrial biopsies. Front Vet Sci. 2023;10.Carluccio A, Veronesi MC, Plenteda D, Mazzatenta A. Platelet-rich plasma uterine infusion and pregnancy rate in barren mares with chronic degenerative endometritis. Pol J Vet Sci. 2020;23(3):431-8.Bazzano M, Marchegiani A, Troisi A, McLean A, Laus F. Serum Amyloid A as a Promising Biomarker in Domestic Animals’ Reproduction: Current Knowledge and Future Perspective. Vol. 12, Animals. MDPI; 2022.Jasiński T, Zdrojkowski Ł, Kautz E, Juszczuk-Kubiak E, Ferreira-Dias G, Domino M. The NF-κB-signalling pathway in mare’s endometrium infiltrated with the inflammatory cells. Reproduction in Domestic Animals. 1 de junio de 2022;57(6):598610.Ferris RA, McCue PM, Borlee GI, Loncar KD, Hennet ML, Borlee BR. In Vitro Efficacy of Nonantibiotic Treatments on Biofilm Disruption of Gram-Negative Pathogens and an in Vivo Model of Infectious Endometritis Utilizing Isolates from the Equine Uterus. J Clin Microbiol. 1 de marzo de 2016;54(3):631-9.Siemieniuch MJ, Szóstek AZ, Gajos K, Kozdrowski R, Nowak M, Okuda K. Type of inflammation differentially affects expression of interleukin 1β and 6, tumor necrosis factor-α and toll-like receptors in subclinical endometritis in mares. PLoS One. 1 de mayo de 2016;11(5).Ibrahim S, Hedia M, Taqi MO, Derbala MK, Mahmoud KGM, Ahmed Y, et al. Extracellular vesicles in low volume uterine lavage and serum: novel and promising biomarker for endometritis in Arabian mares. BMC Vet Res. 1 de diciembre de 2022;18(1).Lange-Consiglio A, Gaspari G, Funghi F, Capra E, Cretich M, Frigerio R, et al. Amniotic Mesenchymal-Derived Extracellular Vesicles and Their Role in the Prevention of Persistent Post-Breeding Induced Endometritis. Int J Mol Sci. 1 de marzo de 2023;24(6).Ferris RA, Mccue PM, Borlee GI, Glapa KE, Martin KH, Mangalea MR, et al. Model of Chronic Equine Endometritis Involving a Pseudomonas aeruginosa Biofilm. 2017; Disponible en: https://doi.org/10.1128/IAIA Morris LH, McCue PM, Aurich C. Equine endometritis: a review of challenges and new approaches. 2020.Garner C, Stephen C, Pant SD, Ghorashi SA. Comparison of PCR-HRM, colorimetric LAMP and culture based diagnostic assays in the detection of endometritis caused by Streptococcus equi subsp. zooepidemicus in mares. Vet Res Commun. 1 de junio de 2023;47(2):495-509.Buczkowska J, Kozdrowski R, Nowak M, Raś A, Staroniewicz Z, Siemieniuch MJ. Comparison of the biopsy and cytobrush techniques for diagnosis of subclinical endometritis in mares. Reproductive Biology and Endocrinology. 4 de abril de 2014;12(1).Ibrahim S, Hedia M, Taqi MO, Derbala MK, Mahmoud KGM, Ahmed Y, et al. Alterations in the expression profile of serum mir-155, mir-223, mir-17, mir-200a, mir-205, as well as levels of interleukin 6, and prostaglandins during endometritis in arabian mares. Vet Sci. 1 de junio de 2021;8(6).Monteiro de Barros MR, Davies-Morel MCG, Mur LAJ, Creevey CJ, Alison RH, Nash DM. Characterization of an ex vivo equine endometrial tissue culture model using next-generation rna-sequencing technology. Animals. 1 de julio de 2021;11(7).Agerholm JS. Coxiella burnetii associated reproductive disorders in domestic animalsa critical review [Internet]. 2013. Disponible en: http://www.actavetscand.com/content/55/1/13Wolf CA, Maslchitzky E, Gregory RM, Jobim MIM, Mattos RC. Effect of corticotherapy on proteomics of endometrial fluid from mares susceptible to persistent postbreeding endometritis. Theriogenology. 15 de abril de 2012;77(7):1351-9.Lara E, Rivera N, Cabezas J, Navarrete F, Saravia F, Rodríguez-Alvarez L, et al. Endometrial stem cells in farm animals: Potential role in uterine physiology and pathology. Vol. 5, Bioengineering. 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