Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control

Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on NK and CD4+ T-cells in indiv...

Full description

Autores:
Taborda, Natalia Andrea
Hernández López, Juan Carlos
Lajoie, Julie
Juno, Jennifer
Kimani, Josua
Rugeles López, María Teresa
Fowke, Keith R.
Tipo de recurso:
Article of journal
Fecha de publicación:
2015
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/1176
Acceso en línea:
https://hdl.handle.net/20.500.12494/1176
Palabra clave:
NK cells
Viral control
Enfermedades infecciosas
Rights
embargoedAccess
License
Licencia CC
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dc.title.spa.fl_str_mv Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
title Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
spellingShingle Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
NK cells
Viral control
Enfermedades infecciosas
title_short Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
title_full Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
title_fullStr Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
title_full_unstemmed Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
title_sort Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
dc.creator.fl_str_mv Taborda, Natalia Andrea
Hernández López, Juan Carlos
Lajoie, Julie
Juno, Jennifer
Kimani, Josua
Rugeles López, María Teresa
Fowke, Keith R.
dc.contributor.author.none.fl_str_mv Taborda, Natalia Andrea
Hernández López, Juan Carlos
Lajoie, Julie
Juno, Jennifer
Kimani, Josua
Rugeles López, María Teresa
Fowke, Keith R.
dc.subject.spa.fl_str_mv NK cells
Viral control
Enfermedades infecciosas
topic NK cells
Viral control
Enfermedades infecciosas
description Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on NK and CD4+ T-cells in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV-controllers. There was lower expression of CD69, LAG-3, PD-1 and TIM-3 in both cohorts when compared to a low-risk population or HIV-progressors. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion.
publishDate 2015
dc.date.issued.none.fl_str_mv 2015-05
dc.date.available.none.fl_str_mv 2016-05
2017-08-18T20:13:17Z
dc.date.accessioned.none.fl_str_mv 2017-08-18T20:13:17Z
dc.type.none.fl_str_mv Artículo
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dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/1176
dc.identifier.bibliographicCitation.spa.fl_str_mv Taborda, N., Hernández, J. C., Lajoie. J., Juno, J., Kimani. J., Rugeles, M. T. & Fowke, K. R. (2015). Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control. AIDS Res Hum Retroviruses. 31(6), 636-640. doi: 10.1089/AID.2014.0325
url https://hdl.handle.net/20.500.12494/1176
identifier_str_mv Taborda, N., Hernández, J. C., Lajoie. J., Juno, J., Kimani. J., Rugeles, M. T. & Fowke, K. R. (2015). Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control. AIDS Res Hum Retroviruses. 31(6), 636-640. doi: 10.1089/AID.2014.0325
dc.relation.isversionof.spa.fl_str_mv http://online.liebertpub.com/doi/10.1089/aid.2014.0325
dc.rights.cc.none.fl_str_mv Licencia CC
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rights_invalid_str_mv Licencia CC
http://purl.org/coar/access_right/c_f1cf
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dc.publisher.spa.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000
dc.publisher.program.spa.fl_str_mv Medicina
dc.publisher.place.spa.fl_str_mv Medellín
institution Universidad Cooperativa de Colombia
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spelling Taborda, Natalia AndreaHernández López, Juan CarlosLajoie, JulieJuno, JenniferKimani, JosuaRugeles López, María TeresaFowke, Keith R.2017-08-18T20:13:17Z2016-052017-08-18T20:13:17Z2015-05https://hdl.handle.net/20.500.12494/1176Taborda, N., Hernández, J. C., Lajoie. J., Juno, J., Kimani. J., Rugeles, M. T. & Fowke, K. R. (2015). Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control. AIDS Res Hum Retroviruses. 31(6), 636-640. doi: 10.1089/AID.2014.0325Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on NK and CD4+ T-cells in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV-controllers. There was lower expression of CD69, LAG-3, PD-1 and TIM-3 in both cohorts when compared to a low-risk population or HIV-progressors. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion.juanc.hernandezl@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000MedicinaMedellínhttp://online.liebertpub.com/doi/10.1089/aid.2014.0325NK cellsViral controlEnfermedades infecciosasShort Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral controlArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia CCinfo:eu-repo/semantics/embargoedAccesshttp://purl.org/coar/access_right/c_f1cfPublicationORIGINALPre-print low expression.pdfPre-print low 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