Short Communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T-cells is associated with viral control
Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on NK and CD4+ T-cells in indiv...
- Autores:
-
Taborda, Natalia Andrea
Hernández López, Juan Carlos
Lajoie, Julie
Juno, Jennifer
Kimani, Josua
Rugeles López, María Teresa
Fowke, Keith R.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2015
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/1176
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/1176
- Palabra clave:
- NK cells
Viral control
Enfermedades infecciosas
- Rights
- embargoedAccess
- License
- Licencia CC
| Summary: | Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on NK and CD4+ T-cells in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV-controllers. There was lower expression of CD69, LAG-3, PD-1 and TIM-3 in both cohorts when compared to a low-risk population or HIV-progressors. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion. |
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