Genomic epidemiology of severe acute Respiratory Syndrome Coronavirus 2, Colombia

Coronavirus disease (COVID-19) in Colombia was first diagnosed in a traveler arriving from Italy on February 26, 2020. However, limited data are available on the origins and number of introductions of COVID-19 into the country. We sequenced the causative agent of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from 43 clinical samples we collected, along with another 79 genome sequences available from Colombia. We investigated the emergence and importation routes for SARSCoV-2 into Colombia by using epidemiologic, historical air travel, and phylogenetic observations. Our study provides evidence of multiple introductions, mostly from Europe, and documents >12 lineages. Phylogenetic findings validate the lineage diversity, support multiple importation events, and demonstrate the evolutionary relationship of epidemiologically linked transmission chains. Our results reconstruct the early evolutionary history of SARS-CoV-2 in Colombia and highlight the advantages of genome sequencing to complement COVID-19 outbreak investigations.

• Autores: Laiton Donato, Katherine; Villabona Arenas, Christian J.; Usme Ciro, José Aldemar; Franco Muñoz, Carlos; Álvarez Díaz, Diego Alejandro; Villabona Arenas, Liz S.; Echeverria Londoño, Susy; Cucunuba, Zulma M.; Franco Sierra, Nicolas D.; Flórez Sánchez, Astrid C.; Ferro, Carolina; Ajami, Nadim J.; Walteros, Diana Marcela; Prieto, Franklin; Duran, Carlos A.; Ospina Martínez, Martha L.; Mercado Reyes, Marcela
• Tipo de recurso: Article of journal
• Fecha de publicación: 2020
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/32678
• Acceso en línea: https://hdl.handle.net/20.500.12494/32678
• Palabra clave: Coronavirus; Secuenciación; Filogenómica; COVID-19; Colombia; SARS-CoV-2; Genome sequencing; Phylogenomics; COVID-19; Colombia
• Rights: openAccess
• License: Atribución