Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings
Dengue is the most important arthropod-borne viral infection of humans. However, its viral pathogenesis is still unknown. The information collected from dengue fatal cases is crucial for understanding the complex interactions between virulence and host factors. This study aimed to establish possible...
- Autores:
-
Rivera, Jorge Alonso
Rengifo, Aura Caterine
Álvarez Díaz, Diego Alejandro
Parra, Edgar
Usme Ciro, José Aldemar
Castellanos, Jaime
Velandia, Myriam
Laiton Donato, Katherine
Rico, Angélica
Pardo, Lisseth
Caldas, Maria Leonor
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- eng
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/55524
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/55524
- Palabra clave:
- 610 - Medicina y salud
Dengue
Viral disease
Aedes albopictus mosquitoes
- Rights
- openAccess
- License
- http://creativecommons.org/licenses/by-nc-nd/4.0/
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Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings |
| title |
Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings |
| spellingShingle |
Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings 610 - Medicina y salud Dengue Viral disease Aedes albopictus mosquitoes |
| title_short |
Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings |
| title_full |
Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings |
| title_fullStr |
Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings |
| title_full_unstemmed |
Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings |
| title_sort |
Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings |
| dc.creator.fl_str_mv |
Rivera, Jorge Alonso Rengifo, Aura Caterine Álvarez Díaz, Diego Alejandro Parra, Edgar Usme Ciro, José Aldemar Castellanos, Jaime Velandia, Myriam Laiton Donato, Katherine Rico, Angélica Pardo, Lisseth Caldas, Maria Leonor |
| dc.contributor.author.none.fl_str_mv |
Rivera, Jorge Alonso Rengifo, Aura Caterine Álvarez Díaz, Diego Alejandro Parra, Edgar Usme Ciro, José Aldemar Castellanos, Jaime Velandia, Myriam Laiton Donato, Katherine Rico, Angélica Pardo, Lisseth Caldas, Maria Leonor |
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CIST-Centro de Investigación en Salud para el Trópico |
| dc.subject.ddc.none.fl_str_mv |
610 - Medicina y salud |
| topic |
610 - Medicina y salud Dengue Viral disease Aedes albopictus mosquitoes |
| dc.subject.proposal.none.fl_str_mv |
Dengue Viral disease Aedes albopictus mosquitoes |
| description |
Dengue is the most important arthropod-borne viral infection of humans. However, its viral pathogenesis is still unknown. The information collected from dengue fatal cases is crucial for understanding the complex interactions between virulence and host factors. This study aimed to establish possible associations between the clinical characteristics, histopathological changes, replication, and tissue location of viral serotypes in dengue fatal cases. Clinical and histopathological characterizations, antigen localization in tissue, and detection of the infecting serotype and replication using real-time polymerase chain reaction were all performed on the dengue fatal cases. The majority of the cases involved people under the age of 20. Bleeding (48.3%), abdominal pain (44.8%), myalgia (52.9%), and headache (48.3%) were the most common clinical manifestations in the cases. There was multiorgan pathology, with histopathological changes primarily in the liver, spleen, and lung. Similarly, the viral antigen was found primarily in these organs; however, there were no associations between tissue changes, viral location, infecting serotypes, and replication processes. Dengue infection should be considered a multiorgan disease, the outcome of which is possibly not associated with the infecting viral serotype. |
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2023 |
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2023-08-21 |
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2024-05-06T19:54:00Z |
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2024-05-06T19:54:00Z |
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Artículo |
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Rivera J, Rengifo A.C., Alvarez Díaz D., Parra E, Usme Ciro J.A., Castellanos J., Velandia M., Laiton-Donato K, Rico A, Pardo L., Caldas M.L. Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings. Am J Trop Med Hyg. 2023 Aug 21:tpmd220587. doi: 10.4269/ajtmh.22-0587 |
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0002-9637 |
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https://hdl.handle.net/20.500.12494/55524 |
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doi.org/10.4269/ajtmh.22-0587 |
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1476-1645 |
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Rivera J, Rengifo A.C., Alvarez Díaz D., Parra E, Usme Ciro J.A., Castellanos J., Velandia M., Laiton-Donato K, Rico A, Pardo L., Caldas M.L. Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings. Am J Trop Med Hyg. 2023 Aug 21:tpmd220587. doi: 10.4269/ajtmh.22-0587 0002-9637 doi.org/10.4269/ajtmh.22-0587 1476-1645 |
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eng |
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eng |
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tpmd220587 |
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916 |
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4 |
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908 |
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109 |
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The American Journal of Tropical Medicine and Hygiene |
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Messina JP. et al., 2019. The current and future global distribution and population at risk of dengue. Nat Microbiol 4: 1508–1515. Bhatt S. et al., 2013. The global distribution and burden of dengue. Nature 496: 504–507. Iglesias NG, Gamarnik AV, 2011. Dynamic RNA structures in the dengue virus genome. RNA Biol 8: 249–257. Endy TP, Anderson KB, Nisalak A, Yoon I-K, Green S, Rothman AL, Thomas SJ, Jarman RG, Libraty DH, Gibbons RV, 2011. Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand. PLoS Negl Trop Dis 5: e975. Cruz-Oliveira C, Freire JM, Conceicao TM, Higa LM, Castanho MA, Da Poian AT, 2015. Receptors and routes of dengue virus entry into the host cells. FEMS Microbiol Rev 39: 155–170. Huerre MR. et al., 2001. Liver histopathology and biological correlates in five cases of fatal dengue fever in Vietnamese children. Virchows Arch 438: 107–115. Couvelard A, Marianneau P, Bedel C, Drouet MT, Vachon F, Henin D, Deubel V, 1999. Report of a fatal case of dengue infection with hepatitis: demonstration of dengue antigens in hepatocytes and liver apoptosis. Hum Pathol 30: 1106–1110. Basilio-de-Oliveira CA, Aguiar GR, Baldanza MS, Barth OM, Eyer-Silva WA, Paes MV, 2005. Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil. Braz J Infect Dis 9: 341–347. Bhamarapravati N, Tuchinda P, Boonyapaknavik V, 1967. Pathology of Thailand haemorrhagic fever: a study of 100 autopsy cases. Ann Trop Med Parasitol 61: 500–510. Sarmiento L, Rengifo AC, Rivera J, Neira M, Parra E, Mendez J, Rodríguez G, Caldas ML, 2013. Glucógeno hepático en dengue severo: análisis histopatológico. Infect 17: 172–176. |
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9 páginas |
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Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Santa Marta |
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Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Santa Marta |
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Rivera, Jorge AlonsoRengifo, Aura CaterineÁlvarez Díaz, Diego AlejandroParra, EdgarUsme Ciro, José AldemarCastellanos, JaimeVelandia, MyriamLaiton Donato, KatherineRico, AngélicaPardo, LissethCaldas, Maria LeonorCIST-Centro de Investigación en Salud para el Trópico2024-05-06T19:54:00Z2024-05-06T19:54:00Z2023-08-21Rivera J, Rengifo A.C., Alvarez Díaz D., Parra E, Usme Ciro J.A., Castellanos J., Velandia M., Laiton-Donato K, Rico A, Pardo L., Caldas M.L. Multisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological Findings. Am J Trop Med Hyg. 2023 Aug 21:tpmd220587. doi: 10.4269/ajtmh.22-05870002-9637https://hdl.handle.net/20.500.12494/55524doi.org/10.4269/ajtmh.22-05871476-1645Dengue is the most important arthropod-borne viral infection of humans. However, its viral pathogenesis is still unknown. The information collected from dengue fatal cases is crucial for understanding the complex interactions between virulence and host factors. This study aimed to establish possible associations between the clinical characteristics, histopathological changes, replication, and tissue location of viral serotypes in dengue fatal cases. Clinical and histopathological characterizations, antigen localization in tissue, and detection of the infecting serotype and replication using real-time polymerase chain reaction were all performed on the dengue fatal cases. The majority of the cases involved people under the age of 20. Bleeding (48.3%), abdominal pain (44.8%), myalgia (52.9%), and headache (48.3%) were the most common clinical manifestations in the cases. There was multiorgan pathology, with histopathological changes primarily in the liver, spleen, and lung. Similarly, the viral antigen was found primarily in these organs; however, there were no associations between tissue changes, viral location, infecting serotypes, and replication processes. Dengue infection should be considered a multiorgan disease, the outcome of which is possibly not associated with the infecting viral serotype.9 páginasapplication/pdfengUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Medicina, Santa MartaExternohttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessAttribution-NonCommercial-NoDerivatives 4.0 Internationalhttp://purl.org/coar/access_right/c_abf2https://www.ajtmh.org/view/journals/tpmd/109/4/article-p908.xml610 - Medicina y saludDengueViral diseaseAedes albopictus mosquitoesMultisystem Failure in Fatal Dengue: Associations between the Infectious Viral Serotype and Clinical and Histopathological FindingsArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontpmd2205879164908109The American Journal of Tropical Medicine and HygieneMessina JP. et al., 2019. The current and future global distribution and population at risk of dengue. Nat Microbiol 4: 1508–1515.Bhatt S. et al., 2013. The global distribution and burden of dengue. Nature 496: 504–507.Iglesias NG, Gamarnik AV, 2011. Dynamic RNA structures in the dengue virus genome. RNA Biol 8: 249–257.Endy TP, Anderson KB, Nisalak A, Yoon I-K, Green S, Rothman AL, Thomas SJ, Jarman RG, Libraty DH, Gibbons RV, 2011. Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in Kamphaeng Phet, Thailand. PLoS Negl Trop Dis 5: e975.Cruz-Oliveira C, Freire JM, Conceicao TM, Higa LM, Castanho MA, Da Poian AT, 2015. Receptors and routes of dengue virus entry into the host cells. FEMS Microbiol Rev 39: 155–170.Huerre MR. et al., 2001. Liver histopathology and biological correlates in five cases of fatal dengue fever in Vietnamese children. Virchows Arch 438: 107–115.Couvelard A, Marianneau P, Bedel C, Drouet MT, Vachon F, Henin D, Deubel V, 1999. Report of a fatal case of dengue infection with hepatitis: demonstration of dengue antigens in hepatocytes and liver apoptosis. Hum Pathol 30: 1106–1110.Basilio-de-Oliveira CA, Aguiar GR, Baldanza MS, Barth OM, Eyer-Silva WA, Paes MV, 2005. Pathologic study of a fatal case of dengue-3 virus infection in Rio de Janeiro, Brazil. Braz J Infect Dis 9: 341–347.Bhamarapravati N, Tuchinda P, Boonyapaknavik V, 1967. Pathology of Thailand haemorrhagic fever: a study of 100 autopsy cases. Ann Trop Med Parasitol 61: 500–510.Sarmiento L, Rengifo AC, Rivera J, Neira M, Parra E, Mendez J, Rodríguez G, Caldas ML, 2013. Glucógeno hepático en dengue severo: análisis histopatológico. 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