Preferential Solvation of Indomethacin in Some Aqueous Co-Solvent Mixtures

The preferential solvation parameters for indomethacin (IMC) in ethanol (EtOH) + water and propylene glycol (PG) + water binary mixtures were obtained from their thermodynamic properties by means of the inverse Kirkwood–Buff integrals (IKBI) and the quasi-lattice quasi-chemical (QLQC) methods. According to IKBI method, the preferential solvation parameter by co-solvents, (dx1,3), is negative in the water-rich mixtures of both binary systems but positive in the other compositions at temperatures of 293.15, 303.15, and 313.15 K. It is conjecturable that in water-rich mixtures the hydrophobic hydration around the aromatic rings and methyl groups of the drug plays a relevant role in the solvation. The higher drug solvation by co-solvent in mixtures of similar solvent proportion and in co-solvent-rich mixtures could be due mainly to polarity effects. Here IMC would be acting as a Lewis acid with the EtOH or PG molecules because these co-solvents are more basic than water. © 2016, Copyright © Taylor & Francis Group, LLC.

• Autores: Peña M.Á.; Delgado, Daniel ricardo; Martínez F.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2023
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/49563
• Acceso en línea: https://doi.org/10.1080/00986445.2015.1074898; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960389987&doi=10.1080%2f00986445.2015.1074898&partnerID=40&md5=47ae1045446a54dd59dfe15802f39ec0; https://hdl.handle.net/20.500.12494/49563
• Palabra clave: BINARY MIXTURES; BINARY SYSTEMS; BINS; COSOLVENT MIXTURES; ETHANOL; GLYCOLS; HYDROPHOBIC HYDRATION; INDOMETHACIN; INVERSE PROBLEMS; MIXTURES; POLARITY EFFECT; POLYOLS; PREFERENTIAL SOLVATION; PROPYLENE; PROPYLENE GLYCOLS; QUASI-CHEMICAL; SOLVATION; SOLVENTS
• Rights: openAccess
• License: http://purl.org/coar/access_right/c_abf2