NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region
Objective: To study the NAT 2 gene polymorphisms 481T, 590A and 857A in the Chimila, Wiwa and Wayuu indigenous groups of the Colombian Caribbean to determine the frequencies of the alleles NAT2*4, NAT2*5, NAT2*6, and NAT2*7 and to determine the types of acetylators present in these populations. Meth...
- Autores:
-
Arias I.
Lecompte N.
Visbal L.
Curiel I.
Hernandez Aguirre, Enio Armando
Garavito P.
Silvera-Redondo C.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2014
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/42854
- Acceso en línea:
- https://doi.org/10.6018/eglobal.13.3.170201
https://hdl.handle.net/20.500.12494/42854
- Palabra clave:
- arylamine acetyltransferase
genomic DNA
arylamine acetyltransferase
NAT2 protein
human
acetylator phenotype
allele
Article
Caribbean
Colombian
female
gene
gene frequency
genetic variability
haplotype
human
male
NAT2 gene
real time polymerase chain reaction
single nucleotide polymorphism
acetylation
American Indian
Colombia
genetics
pharmacogenetics
Acetylation
Alleles
Arylamine N-Acetyltransferase
Colombia
Female
Humans
Indians
South American
Male
Pharmacogenetics
Polymorphism
Single Nucleotide
Real-Time Polymerase Chain Reaction
- Rights
- closedAccess
- License
- http://purl.org/coar/access_right/c_14cb
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Arias I.Lecompte N.Visbal L.Curiel I.Hernandez Aguirre, Enio ArmandoGaravito P.Silvera-Redondo C.2021-12-16T22:16:34Z2021-12-16T22:16:34Z2014https://doi.org/10.6018/eglobal.13.3.17020116579534https://hdl.handle.net/20.500.12494/42854Arias I,Lecompte N,Visbal L,Curiel I,Hernández E,Garavito P,Silvera C. NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region. Colomb Med (Cali). 2014. 45. (4):p. 148-153. .Objective: To study the NAT 2 gene polymorphisms 481T, 590A and 857A in the Chimila, Wiwa and Wayuu indigenous groups of the Colombian Caribbean to determine the frequencies of the alleles NAT2*4, NAT2*5, NAT2*6, and NAT2*7 and to determine the types of acetylators present in these populations. Methods: A total of 202 subjects were studied: 47 Chimila, 55 Wiwa, and 100 Wayuu. Te polymorphisms were identifed using a real-time PCR method for allelic discrimination designed using Taqman of Applied Biosystems. Results: Te following alleles were found at the highest frequency in the following groups: the NAT2*4 allele (wild type) in the Wayuu group (55.3%), the NAT2*5 allele in the Wiwa group (34.5%), and the NAT2*7 allele in the Chimila group (24.2%). A higher frequency of the rapid acetylator status was found in the Wayuu group (31.3%) and Chimila group (29.5%) compared with the Wiwa group (12.7%). Te intermediate acetylator status distribution was very similar in all three groups, and the frequency of the slow acetylator status was higher in the Wiwa group (32.7%) compared with the Chimila and Wayuu groups (20.5% and 21.2%, respectively). Conclusion: Te results demonstrated the allelic distribution and pharmacogenetic diferences of the three groups studied and revealed the most frequent acetylator status and phenotype. Because of the high prevalence of slow acetylators, a greater incidence of tuberculosis (TB) drug-induced hepatotoxicity is predicted in these populations, with a higher frequency in the Wiwa group. © 2014 Universidad del Valle.enio.hernandez@campusucc.edu.co153-148Facultad de Salud de la Universidad del Vallearylamine acetyltransferasegenomic DNAarylamine acetyltransferaseNAT2 proteinhumanacetylator phenotypealleleArticleCaribbeanColombianfemalegenegene frequencygenetic variabilityhaplotypehumanmaleNAT2 genereal time polymerase chain reactionsingle nucleotide polymorphismacetylationAmerican IndianColombiageneticspharmacogeneticsAcetylationAllelesArylamine N-AcetyltransferaseColombiaFemaleHumansIndiansSouth AmericanMalePharmacogeneticsPolymorphismSingle NucleotideReal-Time Polymerase Chain ReactionNAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast regionArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionCOLOMB MEDICAinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/42854oai:repository.ucc.edu.co:20.500.12494/428542024-08-20 16:23:26.873metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com |
| dc.title.spa.fl_str_mv |
NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region |
| title |
NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region |
| spellingShingle |
NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region arylamine acetyltransferase genomic DNA arylamine acetyltransferase NAT2 protein human acetylator phenotype allele Article Caribbean Colombian female gene gene frequency genetic variability haplotype human male NAT2 gene real time polymerase chain reaction single nucleotide polymorphism acetylation American Indian Colombia genetics pharmacogenetics Acetylation Alleles Arylamine N-Acetyltransferase Colombia Female Humans Indians South American Male Pharmacogenetics Polymorphism Single Nucleotide Real-Time Polymerase Chain Reaction |
| title_short |
NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region |
| title_full |
NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region |
| title_fullStr |
NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region |
| title_full_unstemmed |
NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region |
| title_sort |
NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region |
| dc.creator.fl_str_mv |
Arias I. Lecompte N. Visbal L. Curiel I. Hernandez Aguirre, Enio Armando Garavito P. Silvera-Redondo C. |
| dc.contributor.author.none.fl_str_mv |
Arias I. Lecompte N. Visbal L. Curiel I. Hernandez Aguirre, Enio Armando Garavito P. Silvera-Redondo C. |
| dc.subject.spa.fl_str_mv |
arylamine acetyltransferase genomic DNA arylamine acetyltransferase NAT2 protein human acetylator phenotype allele Article Caribbean Colombian female gene gene frequency genetic variability haplotype human male NAT2 gene real time polymerase chain reaction single nucleotide polymorphism acetylation American Indian Colombia genetics pharmacogenetics Acetylation Alleles Arylamine N-Acetyltransferase Colombia Female Humans Indians South American Male Pharmacogenetics Polymorphism Single Nucleotide Real-Time Polymerase Chain Reaction |
| topic |
arylamine acetyltransferase genomic DNA arylamine acetyltransferase NAT2 protein human acetylator phenotype allele Article Caribbean Colombian female gene gene frequency genetic variability haplotype human male NAT2 gene real time polymerase chain reaction single nucleotide polymorphism acetylation American Indian Colombia genetics pharmacogenetics Acetylation Alleles Arylamine N-Acetyltransferase Colombia Female Humans Indians South American Male Pharmacogenetics Polymorphism Single Nucleotide Real-Time Polymerase Chain Reaction |
| description |
Objective: To study the NAT 2 gene polymorphisms 481T, 590A and 857A in the Chimila, Wiwa and Wayuu indigenous groups of the Colombian Caribbean to determine the frequencies of the alleles NAT2*4, NAT2*5, NAT2*6, and NAT2*7 and to determine the types of acetylators present in these populations. Methods: A total of 202 subjects were studied: 47 Chimila, 55 Wiwa, and 100 Wayuu. Te polymorphisms were identifed using a real-time PCR method for allelic discrimination designed using Taqman of Applied Biosystems. Results: Te following alleles were found at the highest frequency in the following groups: the NAT2*4 allele (wild type) in the Wayuu group (55.3%), the NAT2*5 allele in the Wiwa group (34.5%), and the NAT2*7 allele in the Chimila group (24.2%). A higher frequency of the rapid acetylator status was found in the Wayuu group (31.3%) and Chimila group (29.5%) compared with the Wiwa group (12.7%). Te intermediate acetylator status distribution was very similar in all three groups, and the frequency of the slow acetylator status was higher in the Wiwa group (32.7%) compared with the Chimila and Wayuu groups (20.5% and 21.2%, respectively). Conclusion: Te results demonstrated the allelic distribution and pharmacogenetic diferences of the three groups studied and revealed the most frequent acetylator status and phenotype. Because of the high prevalence of slow acetylators, a greater incidence of tuberculosis (TB) drug-induced hepatotoxicity is predicted in these populations, with a higher frequency in the Wiwa group. © 2014 Universidad del Valle. |
| publishDate |
2014 |
| dc.date.issued.none.fl_str_mv |
2014 |
| dc.date.accessioned.none.fl_str_mv |
2021-12-16T22:16:34Z |
| dc.date.available.none.fl_str_mv |
2021-12-16T22:16:34Z |
| dc.type.none.fl_str_mv |
Artículo |
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http://purl.org/coar/resource_type/c_2df8fbb1 |
| dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
| dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
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info:eu-repo/semantics/publishedVersion |
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http://purl.org/coar/resource_type/c_6501 |
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publishedVersion |
| dc.identifier.none.fl_str_mv |
https://doi.org/10.6018/eglobal.13.3.170201 |
| dc.identifier.issn.spa.fl_str_mv |
16579534 |
| dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/42854 |
| dc.identifier.bibliographicCitation.spa.fl_str_mv |
Arias I,Lecompte N,Visbal L,Curiel I,Hernández E,Garavito P,Silvera C. NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region. Colomb Med (Cali). 2014. 45. (4):p. 148-153. . |
| url |
https://doi.org/10.6018/eglobal.13.3.170201 https://hdl.handle.net/20.500.12494/42854 |
| identifier_str_mv |
16579534 Arias I,Lecompte N,Visbal L,Curiel I,Hernández E,Garavito P,Silvera C. NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region. Colomb Med (Cali). 2014. 45. (4):p. 148-153. . |
| dc.relation.ispartofjournal.spa.fl_str_mv |
COLOMB MEDICA |
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info:eu-repo/semantics/closedAccess |
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closedAccess |
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153-148 |
| dc.publisher.spa.fl_str_mv |
Facultad de Salud de la Universidad del Valle |
| institution |
Universidad Cooperativa de Colombia |
| repository.name.fl_str_mv |
Repositorio Institucional Universidad Cooperativa de Colombia |
| repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
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1814247347932102656 |