Reinforced Portland cement porous scaffolds for load-bearing bone tissue engineering applications.

Modified Portland cement porous scaffolds with suitable characteristics for load-bearing bone tissue engineering applications were manufactured by combining the particulate leaching and foaming methods. Non-crosslinked polydimethylsiloxane was evaluated as a potential reinforcing material. The scaffolds presented average porosities between 70 and 80% with mean pore sizes ranging from 300 µm up to 5.0 mm. Non-reinforced scaffolds presented compressive strengths and elastic modulus values of 2.6 and 245 MPa, respectively, whereas reinforced scaffolds exhibited 4.2 and 443 MPa, respectively, an increase of ~62 and 80%. Portland cement scaffolds supported human osteoblast-like cell adhesion, spreading, and propagation (t = 1-28 days). Cell metabolism and alkaline phosphatase activity were found to be enhanced at longer culture intervals (t = 14 days). These results suggest the possibility of obtaining strong and biocompatible scaffolds for bone repair applications from inexpensive, yet technologically advanced materials such as Portland cement.

• Autores: Higuita-Castro N; Gallego-Perez D; Pelaez Vargas, Alejandro; García Quiroz F; Posada OM; López LE; Sarassa CA; Agudelo-Florez P; Monteiro FJ; Litsky AS; Hansford DJ
• Tipo de recurso: Article of journal
• Fecha de publicación: 2023
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/50251
• Acceso en línea: https://doi.org/10.1002/jbm.b.31976; https://hdl.handle.net/20.500.12494/50251
• Palabra clave: BONE; CELL-MATERIAL INTERACTIONS; COMPOSITE/HARD TISSUE; SCAFFOLDS; TISSUE ENGINEERING
• Rights: openAccess
• License: http://purl.org/coar/access_right/c_abf2