Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial

Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups....

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Autores:: Ardila C.M.
Martelo-Cadavid J.F.
Boderth Acosta, G.B,
Ariza-Garcés A.A.
Guzmán I.C.

Tipo de recurso:: Article of journal

Fecha de publicación:: 2015

Institución:: Universidad Cooperativa de Colombia

Repositorio:: Repositorio UCC

Idioma:

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spelling	Ardila C.M.Martelo-Cadavid J.F.Boderth Acosta, G.B,Ariza-Garcés A.A.Guzmán I.C.2021-12-16T22:15:46Z2021-12-16T22:15:46Z2015https://doi.org/10.15665/re.v13i2.49503036979https://hdl.handle.net/20.500.12494/41759Ardila CM,Martelo JF,Boderth G,Ariza AA,Guzmán IC. Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. J Clin Periodontol. 2015. 42. (2):p. 160-168. .Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi-nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria. Results Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD =6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group. Conclusions The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.168-160Blackwell Munksgaardantiinfective agentmoxifloxacinplaceboquinolone derivativeadultAggregatibacter actinomycetemcomitansaggressive periodontitisbacterial loadBacteroidescomparative studycontrolled studydrug effectsfemalefollow upGingival Hemorrhagehumanisolation and purificationmalemicrobiologymultimodality cancer therapyPeriodontal Attachment Lossperiodontal pocketPorphyromonas gingivalispreventive dentistryproceduresrandomized controlled trialtooth plaquetreatment outcomeyoung adultAdultAggregatibacter actinomycetemcomitansAggressive PeriodontitisAnti-Bacterial AgentsBacterial LoadBacteroidesCombined Modality TherapyDental PlaqueDental ScalingFemaleFluoroquinolonesFollow-Up StudiesGingival HemorrhageHumansMalePeriodontal Attachment LossPeriodontal PocketPlacebosPorphyromonas gingivalisRoot PlaningTreatment OutcomeYoung AdultAdjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trialArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionJournal of Clinical Periodontologyinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41759oai:repository.ucc.edu.co:20.500.12494/417592024-08-20 16:18:48.472metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv	Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
title	Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
spellingShingle	Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial antiinfective agent moxifloxacin placebo quinolone derivative adult Aggregatibacter actinomycetemcomitans aggressive periodontitis bacterial load Bacteroides comparative study controlled study drug effects female follow up Gingival Hemorrhage human isolation and purification male microbiology multimodality cancer therapy Periodontal Attachment Loss periodontal pocket Porphyromonas gingivalis preventive dentistry procedures randomized controlled trial tooth plaque treatment outcome young adult Adult Aggregatibacter actinomycetemcomitans Aggressive Periodontitis Anti-Bacterial Agents Bacterial Load Bacteroides Combined Modality Therapy Dental Plaque Dental Scaling Female Fluoroquinolones Follow-Up Studies Gingival Hemorrhage Humans Male Periodontal Attachment Loss Periodontal Pocket Placebos Porphyromonas gingivalis Root Planing Treatment Outcome Young Adult
title_short	Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
title_full	Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
title_fullStr	Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
title_full_unstemmed	Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
title_sort	Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
dc.creator.fl_str_mv	Ardila C.M. Martelo-Cadavid J.F. Boderth Acosta, G.B, Ariza-Garcés A.A. Guzmán I.C.
dc.contributor.author.none.fl_str_mv	Ardila C.M. Martelo-Cadavid J.F. Boderth Acosta, G.B, Ariza-Garcés A.A. Guzmán I.C.
dc.subject.spa.fl_str_mv	antiinfective agent moxifloxacin placebo quinolone derivative adult Aggregatibacter actinomycetemcomitans aggressive periodontitis bacterial load Bacteroides comparative study controlled study drug effects female follow up Gingival Hemorrhage human isolation and purification male microbiology multimodality cancer therapy Periodontal Attachment Loss periodontal pocket Porphyromonas gingivalis preventive dentistry procedures randomized controlled trial tooth plaque treatment outcome young adult Adult Aggregatibacter actinomycetemcomitans Aggressive Periodontitis Anti-Bacterial Agents Bacterial Load Bacteroides Combined Modality Therapy Dental Plaque Dental Scaling Female Fluoroquinolones Follow-Up Studies Gingival Hemorrhage Humans Male Periodontal Attachment Loss Periodontal Pocket Placebos Porphyromonas gingivalis Root Planing Treatment Outcome Young Adult
topic	antiinfective agent moxifloxacin placebo quinolone derivative adult Aggregatibacter actinomycetemcomitans aggressive periodontitis bacterial load Bacteroides comparative study controlled study drug effects female follow up Gingival Hemorrhage human isolation and purification male microbiology multimodality cancer therapy Periodontal Attachment Loss periodontal pocket Porphyromonas gingivalis preventive dentistry procedures randomized controlled trial tooth plaque treatment outcome young adult Adult Aggregatibacter actinomycetemcomitans Aggressive Periodontitis Anti-Bacterial Agents Bacterial Load Bacteroides Combined Modality Therapy Dental Plaque Dental Scaling Female Fluoroquinolones Follow-Up Studies Gingival Hemorrhage Humans Male Periodontal Attachment Loss Periodontal Pocket Placebos Porphyromonas gingivalis Root Planing Treatment Outcome Young Adult
description	Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi-nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria. Results Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD =6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group. Conclusions The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
publishDate	2015
dc.date.issued.none.fl_str_mv	2015
dc.date.accessioned.none.fl_str_mv	2021-12-16T22:15:46Z
dc.date.available.none.fl_str_mv	2021-12-16T22:15:46Z
dc.type.none.fl_str_mv	Artículo
dc.type.coar.fl_str_mv	http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv	http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv	info:eu-repo/semantics/publishedVersion
format	http://purl.org/coar/resource_type/c_6501
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://doi.org/10.15665/re.v13i2.495
dc.identifier.issn.spa.fl_str_mv	03036979
dc.identifier.uri.none.fl_str_mv	https://hdl.handle.net/20.500.12494/41759
dc.identifier.bibliographicCitation.spa.fl_str_mv	Ardila CM,Martelo JF,Boderth G,Ariza AA,Guzmán IC. Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. J Clin Periodontol. 2015. 42. (2):p. 160-168. .
url	https://doi.org/10.15665/re.v13i2.495 https://hdl.handle.net/20.500.12494/41759
identifier_str_mv	03036979 Ardila CM,Martelo JF,Boderth G,Ariza AA,Guzmán IC. Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. J Clin Periodontol. 2015. 42. (2):p. 160-168. .
dc.relation.ispartofjournal.spa.fl_str_mv	Journal of Clinical Periodontology
dc.rights.accessrights.none.fl_str_mv	info:eu-repo/semantics/closedAccess
dc.rights.coar.none.fl_str_mv	http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv	closedAccess
rights_invalid_str_mv	http://purl.org/coar/access_right/c_14cb
dc.format.extent.spa.fl_str_mv	168-160
dc.publisher.spa.fl_str_mv	Blackwell Munksgaard
institution	Universidad Cooperativa de Colombia
repository.name.fl_str_mv	Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv	bdigital@metabiblioteca.com
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Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial

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