Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial

Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups....

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Autores:
Ardila C.M.
Martelo-Cadavid J.F.
Boderth Acosta, G.B,
Ariza-Garcés A.A.
Guzmán I.C.
Tipo de recurso:
Article of journal
Fecha de publicación:
2015
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/41759
Acceso en línea:
https://doi.org/10.15665/re.v13i2.495
https://hdl.handle.net/20.500.12494/41759
Palabra clave:
antiinfective agent
moxifloxacin
placebo
quinolone derivative
adult
Aggregatibacter actinomycetemcomitans
aggressive periodontitis
bacterial load
Bacteroides
comparative study
controlled study
drug effects
female
follow up
Gingival Hemorrhage
human
isolation and purification
male
microbiology
multimodality cancer therapy
Periodontal Attachment Loss
periodontal pocket
Porphyromonas gingivalis
preventive dentistry
procedures
randomized controlled trial
tooth plaque
treatment outcome
young adult
Adult
Aggregatibacter actinomycetemcomitans
Aggressive Periodontitis
Anti-Bacterial Agents
Bacterial Load
Bacteroides
Combined Modality Therapy
Dental Plaque
Dental Scaling
Female
Fluoroquinolones
Follow-Up Studies
Gingival Hemorrhage
Humans
Male
Periodontal Attachment Loss
Periodontal Pocket
Placebos
Porphyromonas gingivalis
Root Planing
Treatment Outcome
Young Adult
Rights
closedAccess
License
http://purl.org/coar/access_right/c_14cb
id COOPER2_2f41f7e499856c42fe7af2306a891527
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/41759
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network_name_str Repositorio UCC
repository_id_str
spelling Ardila C.M.Martelo-Cadavid J.F.Boderth Acosta, G.B,Ariza-Garcés A.A.Guzmán I.C.2021-12-16T22:15:46Z2021-12-16T22:15:46Z2015https://doi.org/10.15665/re.v13i2.49503036979https://hdl.handle.net/20.500.12494/41759Ardila CM,Martelo JF,Boderth G,Ariza AA,Guzmán IC. Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. J Clin Periodontol. 2015. 42. (2):p. 160-168. .Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi-nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria. Results Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD =6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group. Conclusions The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.168-160Blackwell Munksgaardantiinfective agentmoxifloxacinplaceboquinolone derivativeadultAggregatibacter actinomycetemcomitansaggressive periodontitisbacterial loadBacteroidescomparative studycontrolled studydrug effectsfemalefollow upGingival Hemorrhagehumanisolation and purificationmalemicrobiologymultimodality cancer therapyPeriodontal Attachment Lossperiodontal pocketPorphyromonas gingivalispreventive dentistryproceduresrandomized controlled trialtooth plaquetreatment outcomeyoung adultAdultAggregatibacter actinomycetemcomitansAggressive PeriodontitisAnti-Bacterial AgentsBacterial LoadBacteroidesCombined Modality TherapyDental PlaqueDental ScalingFemaleFluoroquinolonesFollow-Up StudiesGingival HemorrhageHumansMalePeriodontal Attachment LossPeriodontal PocketPlacebosPorphyromonas gingivalisRoot PlaningTreatment OutcomeYoung AdultAdjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trialArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionJournal of Clinical Periodontologyinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41759oai:repository.ucc.edu.co:20.500.12494/417592024-08-20 16:18:48.472metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
title Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
spellingShingle Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
antiinfective agent
moxifloxacin
placebo
quinolone derivative
adult
Aggregatibacter actinomycetemcomitans
aggressive periodontitis
bacterial load
Bacteroides
comparative study
controlled study
drug effects
female
follow up
Gingival Hemorrhage
human
isolation and purification
male
microbiology
multimodality cancer therapy
Periodontal Attachment Loss
periodontal pocket
Porphyromonas gingivalis
preventive dentistry
procedures
randomized controlled trial
tooth plaque
treatment outcome
young adult
Adult
Aggregatibacter actinomycetemcomitans
Aggressive Periodontitis
Anti-Bacterial Agents
Bacterial Load
Bacteroides
Combined Modality Therapy
Dental Plaque
Dental Scaling
Female
Fluoroquinolones
Follow-Up Studies
Gingival Hemorrhage
Humans
Male
Periodontal Attachment Loss
Periodontal Pocket
Placebos
Porphyromonas gingivalis
Root Planing
Treatment Outcome
Young Adult
title_short Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
title_full Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
title_fullStr Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
title_full_unstemmed Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
title_sort Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
dc.creator.fl_str_mv Ardila C.M.
Martelo-Cadavid J.F.
Boderth Acosta, G.B,
Ariza-Garcés A.A.
Guzmán I.C.
dc.contributor.author.none.fl_str_mv Ardila C.M.
Martelo-Cadavid J.F.
Boderth Acosta, G.B,
Ariza-Garcés A.A.
Guzmán I.C.
dc.subject.spa.fl_str_mv antiinfective agent
moxifloxacin
placebo
quinolone derivative
adult
Aggregatibacter actinomycetemcomitans
aggressive periodontitis
bacterial load
Bacteroides
comparative study
controlled study
drug effects
female
follow up
Gingival Hemorrhage
human
isolation and purification
male
microbiology
multimodality cancer therapy
Periodontal Attachment Loss
periodontal pocket
Porphyromonas gingivalis
preventive dentistry
procedures
randomized controlled trial
tooth plaque
treatment outcome
young adult
Adult
Aggregatibacter actinomycetemcomitans
Aggressive Periodontitis
Anti-Bacterial Agents
Bacterial Load
Bacteroides
Combined Modality Therapy
Dental Plaque
Dental Scaling
Female
Fluoroquinolones
Follow-Up Studies
Gingival Hemorrhage
Humans
Male
Periodontal Attachment Loss
Periodontal Pocket
Placebos
Porphyromonas gingivalis
Root Planing
Treatment Outcome
Young Adult
topic antiinfective agent
moxifloxacin
placebo
quinolone derivative
adult
Aggregatibacter actinomycetemcomitans
aggressive periodontitis
bacterial load
Bacteroides
comparative study
controlled study
drug effects
female
follow up
Gingival Hemorrhage
human
isolation and purification
male
microbiology
multimodality cancer therapy
Periodontal Attachment Loss
periodontal pocket
Porphyromonas gingivalis
preventive dentistry
procedures
randomized controlled trial
tooth plaque
treatment outcome
young adult
Adult
Aggregatibacter actinomycetemcomitans
Aggressive Periodontitis
Anti-Bacterial Agents
Bacterial Load
Bacteroides
Combined Modality Therapy
Dental Plaque
Dental Scaling
Female
Fluoroquinolones
Follow-Up Studies
Gingival Hemorrhage
Humans
Male
Periodontal Attachment Loss
Periodontal Pocket
Placebos
Porphyromonas gingivalis
Root Planing
Treatment Outcome
Young Adult
description Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi-nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria. Results Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD =6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group. Conclusions The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
publishDate 2015
dc.date.issued.none.fl_str_mv 2015
dc.date.accessioned.none.fl_str_mv 2021-12-16T22:15:46Z
dc.date.available.none.fl_str_mv 2021-12-16T22:15:46Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.15665/re.v13i2.495
dc.identifier.issn.spa.fl_str_mv 03036979
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/41759
dc.identifier.bibliographicCitation.spa.fl_str_mv Ardila CM,Martelo JF,Boderth G,Ariza AA,Guzmán IC. Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. J Clin Periodontol. 2015. 42. (2):p. 160-168. .
url https://doi.org/10.15665/re.v13i2.495
https://hdl.handle.net/20.500.12494/41759
identifier_str_mv 03036979
Ardila CM,Martelo JF,Boderth G,Ariza AA,Guzmán IC. Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. J Clin Periodontol. 2015. 42. (2):p. 160-168. .
dc.relation.ispartofjournal.spa.fl_str_mv Journal of Clinical Periodontology
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_14cb
dc.format.extent.spa.fl_str_mv 168-160
dc.publisher.spa.fl_str_mv Blackwell Munksgaard
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
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