Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial
Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups....
- Autores:
-
Ardila C.M.
Martelo-Cadavid J.F.
Boderth Acosta, G.B,
Ariza-Garcés A.A.
Guzmán I.C.
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2015
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/41759
- Palabra clave:
- antiinfective agent
moxifloxacin
placebo
quinolone derivative
adult
Aggregatibacter actinomycetemcomitans
aggressive periodontitis
bacterial load
Bacteroides
comparative study
controlled study
drug effects
female
follow up
Gingival Hemorrhage
human
isolation and purification
male
microbiology
multimodality cancer therapy
Periodontal Attachment Loss
periodontal pocket
Porphyromonas gingivalis
preventive dentistry
procedures
randomized controlled trial
tooth plaque
treatment outcome
young adult
Adult
Aggregatibacter actinomycetemcomitans
Aggressive Periodontitis
Anti-Bacterial Agents
Bacterial Load
Bacteroides
Combined Modality Therapy
Dental Plaque
Dental Scaling
Female
Fluoroquinolones
Follow-Up Studies
Gingival Hemorrhage
Humans
Male
Periodontal Attachment Loss
Periodontal Pocket
Placebos
Porphyromonas gingivalis
Root Planing
Treatment Outcome
Young Adult
- Rights
- closedAccess
- License
- http://purl.org/coar/access_right/c_14cb
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Ardila C.M.Martelo-Cadavid J.F.Boderth Acosta, G.B,Ariza-Garcés A.A.Guzmán I.C.2021-12-16T22:15:46Z2021-12-16T22:15:46Z2015https://doi.org/10.15665/re.v13i2.49503036979https://hdl.handle.net/20.500.12494/41759Ardila CM,Martelo JF,Boderth G,Ariza AA,Guzmán IC. Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. J Clin Periodontol. 2015. 42. (2):p. 160-168. .Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi-nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria. Results Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD =6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group. Conclusions The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.168-160Blackwell Munksgaardantiinfective agentmoxifloxacinplaceboquinolone derivativeadultAggregatibacter actinomycetemcomitansaggressive periodontitisbacterial loadBacteroidescomparative studycontrolled studydrug effectsfemalefollow upGingival Hemorrhagehumanisolation and purificationmalemicrobiologymultimodality cancer therapyPeriodontal Attachment Lossperiodontal pocketPorphyromonas gingivalispreventive dentistryproceduresrandomized controlled trialtooth plaquetreatment outcomeyoung adultAdultAggregatibacter actinomycetemcomitansAggressive PeriodontitisAnti-Bacterial AgentsBacterial LoadBacteroidesCombined Modality TherapyDental PlaqueDental ScalingFemaleFluoroquinolonesFollow-Up StudiesGingival HemorrhageHumansMalePeriodontal Attachment LossPeriodontal PocketPlacebosPorphyromonas gingivalisRoot PlaningTreatment OutcomeYoung AdultAdjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trialArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionJournal of Clinical Periodontologyinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41759oai:repository.ucc.edu.co:20.500.12494/417592024-08-20 16:18:48.472metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com |
dc.title.spa.fl_str_mv |
Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial |
title |
Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial |
spellingShingle |
Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial antiinfective agent moxifloxacin placebo quinolone derivative adult Aggregatibacter actinomycetemcomitans aggressive periodontitis bacterial load Bacteroides comparative study controlled study drug effects female follow up Gingival Hemorrhage human isolation and purification male microbiology multimodality cancer therapy Periodontal Attachment Loss periodontal pocket Porphyromonas gingivalis preventive dentistry procedures randomized controlled trial tooth plaque treatment outcome young adult Adult Aggregatibacter actinomycetemcomitans Aggressive Periodontitis Anti-Bacterial Agents Bacterial Load Bacteroides Combined Modality Therapy Dental Plaque Dental Scaling Female Fluoroquinolones Follow-Up Studies Gingival Hemorrhage Humans Male Periodontal Attachment Loss Periodontal Pocket Placebos Porphyromonas gingivalis Root Planing Treatment Outcome Young Adult |
title_short |
Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial |
title_full |
Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial |
title_fullStr |
Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial |
title_full_unstemmed |
Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial |
title_sort |
Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial |
dc.creator.fl_str_mv |
Ardila C.M. Martelo-Cadavid J.F. Boderth Acosta, G.B, Ariza-Garcés A.A. Guzmán I.C. |
dc.contributor.author.none.fl_str_mv |
Ardila C.M. Martelo-Cadavid J.F. Boderth Acosta, G.B, Ariza-Garcés A.A. Guzmán I.C. |
dc.subject.spa.fl_str_mv |
antiinfective agent moxifloxacin placebo quinolone derivative adult Aggregatibacter actinomycetemcomitans aggressive periodontitis bacterial load Bacteroides comparative study controlled study drug effects female follow up Gingival Hemorrhage human isolation and purification male microbiology multimodality cancer therapy Periodontal Attachment Loss periodontal pocket Porphyromonas gingivalis preventive dentistry procedures randomized controlled trial tooth plaque treatment outcome young adult Adult Aggregatibacter actinomycetemcomitans Aggressive Periodontitis Anti-Bacterial Agents Bacterial Load Bacteroides Combined Modality Therapy Dental Plaque Dental Scaling Female Fluoroquinolones Follow-Up Studies Gingival Hemorrhage Humans Male Periodontal Attachment Loss Periodontal Pocket Placebos Porphyromonas gingivalis Root Planing Treatment Outcome Young Adult |
topic |
antiinfective agent moxifloxacin placebo quinolone derivative adult Aggregatibacter actinomycetemcomitans aggressive periodontitis bacterial load Bacteroides comparative study controlled study drug effects female follow up Gingival Hemorrhage human isolation and purification male microbiology multimodality cancer therapy Periodontal Attachment Loss periodontal pocket Porphyromonas gingivalis preventive dentistry procedures randomized controlled trial tooth plaque treatment outcome young adult Adult Aggregatibacter actinomycetemcomitans Aggressive Periodontitis Anti-Bacterial Agents Bacterial Load Bacteroides Combined Modality Therapy Dental Plaque Dental Scaling Female Fluoroquinolones Follow-Up Studies Gingival Hemorrhage Humans Male Periodontal Attachment Loss Periodontal Pocket Placebos Porphyromonas gingivalis Root Planing Treatment Outcome Young Adult |
description |
Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi-nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria. Results Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD =6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group. Conclusions The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. |
publishDate |
2015 |
dc.date.issued.none.fl_str_mv |
2015 |
dc.date.accessioned.none.fl_str_mv |
2021-12-16T22:15:46Z |
dc.date.available.none.fl_str_mv |
2021-12-16T22:15:46Z |
dc.type.none.fl_str_mv |
Artículo |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://doi.org/10.15665/re.v13i2.495 |
dc.identifier.issn.spa.fl_str_mv |
03036979 |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/41759 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
Ardila CM,Martelo JF,Boderth G,Ariza AA,Guzmán IC. Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. J Clin Periodontol. 2015. 42. (2):p. 160-168. . |
url |
https://doi.org/10.15665/re.v13i2.495 https://hdl.handle.net/20.500.12494/41759 |
identifier_str_mv |
03036979 Ardila CM,Martelo JF,Boderth G,Ariza AA,Guzmán IC. Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial. J Clin Periodontol. 2015. 42. (2):p. 160-168. . |
dc.relation.ispartofjournal.spa.fl_str_mv |
Journal of Clinical Periodontology |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/closedAccess |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_14cb |
eu_rights_str_mv |
closedAccess |
rights_invalid_str_mv |
http://purl.org/coar/access_right/c_14cb |
dc.format.extent.spa.fl_str_mv |
168-160 |
dc.publisher.spa.fl_str_mv |
Blackwell Munksgaard |
institution |
Universidad Cooperativa de Colombia |
repository.name.fl_str_mv |
Repositorio Institucional Universidad Cooperativa de Colombia |
repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
_version_ |
1814246892691783680 |