Adjunctive moxifloxacin in the treatment of generalized aggressive periodontitis patients: clinical and microbiological results of a randomized, triple-blind and placebo-controlled clinical trial

Aim The aim of the present study was to evaluate the clinical and microbiological efficacy of moxifloxacin (MOX) in one-stage scaling and root planing (SRP) in treating generalized aggressive periodontitis (GAgP). Materials and Methods Forty subjects were randomly allocated to two treatment groups. The two treatment groups consisted of SRP combined with systemically admi-nistered MOX at the dosage of 400 mg once daily for 7 days or SRP + placebo once daily for 7 days. Subgingival plaque samples were analysed for cultivable bacteria. Results Both groups resulted in significant reduction of probing depth (PD) and clinical attachment level (CAL) compared with baseline (p < 0.0001), and this difference was maintained at 6 months from baseline in both groups. However, subjects receiving MOX showed the greatest improvements CAL, and PD. Subjects in both groups at 6 months displayed the greatest reduction from baseline in frequency of sites with PD =6 mm (p < 0.001), favouring the MOX group. Adjunctive antibiotic protocol reduced subgingival Aggregatibacter actinomycetemcomitans to undetectable levels, after 3 and 6 months, and there was a significant reduction in the levels of Porphyromonas gingivalis and Tannerella forsythia in the MOX group compared to the placebo group. Conclusions The results from this study suggest that moxifloxacin as and adjunct to one-stage full-mouth SRP leads to a better clinical and microbiological advantages compared to mechanical treatment. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

• Autores: Ardila C.M.; Martelo-Cadavid J.F.; Boderth Acosta, G.B,; Ariza-Garcés A.A.; Guzmán I.C.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2015
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/41759
• Acceso en línea: https://doi.org/10.15665/re.v13i2.495; https://hdl.handle.net/20.500.12494/41759
• Palabra clave: antiinfective agent; moxifloxacin; placebo; quinolone derivative; adult; Aggregatibacter actinomycetemcomitans; aggressive periodontitis; bacterial load; Bacteroides; comparative study; controlled study; drug effects; female; follow up; Gingival Hemorrhage; human; isolation and purification; male; microbiology; multimodality cancer therapy; Periodontal Attachment Loss; periodontal pocket; Porphyromonas gingivalis; preventive dentistry; procedures; randomized controlled trial; tooth plaque; treatment outcome; young adult; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Anti-Bacterial Agents; Bacterial Load; Bacteroides; Combined Modality Therapy; Dental Plaque; Dental Scaling; Female; Fluoroquinolones; Follow-Up Studies; Gingival Hemorrhage; Humans; Male; Periodontal Attachment Loss; Periodontal Pocket; Placebos; Porphyromonas gingivalis; Root Planing; Treatment Outcome; Young Adult
• Rights: closedAccess
• License: http://purl.org/coar/access_right/c_14cb