Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis

Objective: The treatment of cutaneous leishmaniasis is toxic, has contraindications, and a high cost. The objective of this study was to estimate the cost-effectiveness of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. Methods: Effectiveness was the proportion of healing and safety with the adverse effects; these parameters were estimated from a controlled clinical trial and a meta-analysis. A standard costing was conducted. Average and incremental cost-effectiveness ratios were estimated. The uncertainty regarding effectiveness, safety, and costs was determined through sensitivity analyses. Results: The total costs were $66,807 with Glucantime and $14,079 with thermotherapy. The therapeutic effectiveness rates were 64.2% for thermotherapy and 85.1% for Glucantime. The average cost-effectiveness ratios ranged between $721 and $1275 for Glucantime and between $187 and $390 for thermotherapy. Based on the meta-analysis, thermotherapy may be a dominant strategy. Conclusion: The excellent cost-effectiveness ratio of thermotherapy shows the relevance of its inclusion in guidelines for the treatment. © 2017 Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd

• Autores: Cardona Arias, Jaiberth antonio; López-Carvajal L.; Tamayo Plata M.P.; Vélez I.D.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2023
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/50961
• Acceso en línea: https://doi.org/10.1111/jebm.12245; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019982051&doi=10.1111%2fjebm.12245&partnerID=40&md5=9b2968aa37cefaebd7cf731205e9cb77; https://hdl.handle.net/20.500.12494/50961
• Palabra clave: ANTIMONY SODIUM GLUCONATE; COLOMBIA; COST-EFFECTIVENESS ANALYSIS; CUTANEOUS LEISHMANIASIS; THERMOTHERAPY
• Rights: openAccess
• License: http://purl.org/coar/access_right/c_abf2