Participación de la vitamina D en la patogénesis de la infección por el virus de la inmunodeficiencia humana tipo 1

Beyond its role in mineral metabolism, vitamin D (VitD) has immunomodulatory functions and can actively participate in the physiopathogenesis of HIV-1 infection; however, scientific evidence in this field is limited and controversial. VitD has anti-inflammatory properties that can reduce immune hyperactivation, decreasing the damage associated with this phenomenon. It also promotes the expression of antimicrobial peptides with anti-HIV-1 activity, supporting its protective role. In contrast, VitD activates the HIV-1 promoter and can increase viral replication. Furthermore, a number of allelic variants in the vitamin D receptor gene,which increase its function, have been associated with susceptibility to HIV-1 infection. Given the implications of this topic for the identification of new therapeutic targets in HIV infection, this review presents scientific evidence on the effect of the VitD pathway in HIV-1 pathogenesis. © 2013 ACIN.

• Autores: Aguilar-Jiménez W.; Zapata Builes, Wildeman; Rugeles L. M.T.
• Tipo de recurso: Article of journal
• Fecha de publicación: 2023
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/49716
• Acceso en línea: https://doi.org/10.1016/s0123-9392(13)70721-5; https://www.scopus.com/inward/record.uri?eid=2-s2.0-84909985900&partnerID=40&md5=136c41b87aad4f05fe94b0b94622a4db; https://hdl.handle.net/20.500.12494/49716
• Palabra clave: ALLELE; ARTICLE; GENETIC VARIABILITY; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IMMUNOMODULATION; INFECTION SENSITIVITY; PROTEIN EXPRESSION; VIRUS PATHOGENESIS; VIRUS REPLICATION; VITAMIN D; VITAMIN D RECEPTOR
• Rights: openAccess
• License: http://purl.org/coar/access_right/c_abf2