Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection

The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheralblood, along with higher CYP24A1 mRN...

Full description

Autores:
Aguilar Jiménez, Wbeimar
Zapata Builes, Wildeman
Rugeles López, María Teresa
Tipo de recurso:
Article of journal
Fecha de publicación:
2016
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/1349
Acceso en línea:
https://hdl.handle.net/20.500.12494/1349
Palabra clave:
HIV-1
Natural resistance to HIV-1
HIV-1-exposed seronegative individuals (HESNs)
Antiviral agents
Vitamin D
Rights
embargoedAccess
License
Licencia CC
id COOPER2_2802d7446e7e8d7efa1d3347b25068ca
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/1349
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
spellingShingle Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
HIV-1
Natural resistance to HIV-1
HIV-1-exposed seronegative individuals (HESNs)
Antiviral agents
Vitamin D
title_short Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_full Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_fullStr Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_full_unstemmed Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
title_sort Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
dc.creator.fl_str_mv Aguilar Jiménez, Wbeimar
Zapata Builes, Wildeman
Rugeles López, María Teresa
dc.contributor.author.none.fl_str_mv Aguilar Jiménez, Wbeimar
Zapata Builes, Wildeman
Rugeles López, María Teresa
dc.subject.spa.fl_str_mv HIV-1
Natural resistance to HIV-1
HIV-1-exposed seronegative individuals (HESNs)
Antiviral agents
Vitamin D
topic HIV-1
Natural resistance to HIV-1
HIV-1-exposed seronegative individuals (HESNs)
Antiviral agents
Vitamin D
description The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheralblood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1.
publishDate 2016
dc.date.issued.none.fl_str_mv 2016-07
dc.date.accessioned.none.fl_str_mv 2017-08-24T14:10:50Z
dc.date.available.none.fl_str_mv 2017-07
2017-08-24T14:10:50Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/1349
dc.identifier.bibliographicCitation.spa.fl_str_mv Aguilar Jimenez, W., Zapata W., & Rugeles M. (2016). Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection. Microbes and Infect, ;18(7-8), 510–516.
url https://hdl.handle.net/20.500.12494/1349
identifier_str_mv Aguilar Jimenez, W., Zapata W., & Rugeles M. (2016). Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection. Microbes and Infect, ;18(7-8), 510–516.
dc.relation.isversionof.spa.fl_str_mv http://www.sciencedirect.com/science/article/pii/S1286457916300272?via%3Dihub
dc.rights.cc.none.fl_str_mv Licencia CC
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/embargoedAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_f1cf
rights_invalid_str_mv Licencia CC
http://purl.org/coar/access_right/c_f1cf
eu_rights_str_mv embargoedAccess
dc.publisher.spa.fl_str_mv Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000
dc.publisher.program.spa.fl_str_mv Medicina
dc.publisher.place.spa.fl_str_mv Medellín
institution Universidad Cooperativa de Colombia
bitstream.url.fl_str_mv https://repository.ucc.edu.co/bitstreams/ad4e32b3-09b8-4c94-a50e-bb0b9c57e7ac/download
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spelling Aguilar Jiménez, WbeimarZapata Builes, WildemanRugeles López, María Teresa2017-08-24T14:10:50Z2017-072017-08-24T14:10:50Z2016-07https://hdl.handle.net/20.500.12494/1349Aguilar Jimenez, W., Zapata W., & Rugeles M. (2016). Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection. Microbes and Infect, ;18(7-8), 510–516.The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheralblood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1.wildeman.zapatab@campusucc.edu.coUniversidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000MedicinaMedellínhttp://www.sciencedirect.com/science/article/pii/S1286457916300272?via%3DihubHIV-1Natural resistance to HIV-1HIV-1-exposed seronegative individuals (HESNs)Antiviral agentsVitamin DAntiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infectionArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionLicencia CCinfo:eu-repo/semantics/embargoedAccesshttp://purl.org/coar/access_right/c_f1cfPublicationORIGINALAntiviral molecules correlate with vitamin D pathway genes.docxAntiviral molecules correlate with vitamin D pathway genes.docxapplication/vnd.openxmlformats-officedocument.wordprocessingml.document95891https://repository.ucc.edu.co/bitstreams/ad4e32b3-09b8-4c94-a50e-bb0b9c57e7ac/download57c16bfcea6b447a2c55fe2918984a32MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-84553https://repository.ucc.edu.co/bitstreams/410cdc24-71ce-49b3-b1f5-c9dc3c516479/downloadcb8f4d9b72d863ad6737f22af442cc82MD52TEXTAntiviral molecules correlate with vitamin D pathway genes.docx.txtAntiviral molecules correlate with vitamin D pathway genes.docx.txtExtracted texttext/plain27476https://repository.ucc.edu.co/bitstreams/971118db-2d2f-4fc6-b780-2e1596d5d0c7/download876ffba2c47582fe2ef77a1088fe0dccMD5320.500.12494/1349oai:repository.ucc.edu.co:20.500.12494/13492024-08-10 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