Antiviral molecules correlate with vitamin D pathway genes and are associated with natural resistance to HIV-1 infection
The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheralblood, along with higher CYP24A1 mRN...
- Autores:
-
Aguilar Jiménez, Wbeimar
Zapata Builes, Wildeman
Rugeles López, María Teresa
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2016
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/1349
- Acceso en línea:
- https://hdl.handle.net/20.500.12494/1349
- Palabra clave:
- HIV-1
Natural resistance to HIV-1
HIV-1-exposed seronegative individuals (HESNs)
Antiviral agents
Vitamin D
- Rights
- embargoedAccess
- License
- Licencia CC
| Summary: | The relationship between the immunomodulatory effects of Vitamin D (VitD) and the expression of anti-HIV-1 molecules has not been explored in HIV-1-exposed seronegative individuals (HESNs). Higher mRNA levels of cathelicidin and HAD-4 in oral-mucosa and peripheralblood, along with higher CYP24A1 mRNA in vaginal-mucosa and lower TLR2 mRNA in endocervical-mucosa were found in HESNs compared to non-exposed controls. Furthermore, the mRNA of anti-HIV molecules Elafin, TRIM5, Cathelicidin, HAD-4 and RNase7, previously associated with natural resistance to HIV-1 infection, positively correlated with the mRNA expression of VDR in HESNs, suggesting the potential participation of VitD in natural resistance to HIV-1. |
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