Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
Emergent biological responses develop via unknown processes dependent on physical collision. In hypoxia, when the tissue architecture collapses but the geometric core is stable, actin cytoskeleton filament components emerge, revealing a hidden internal order that identifies how each molecule is reas...
- Autores:
-
Diaz Torres, Jairo alberto
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2023
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/49987
- Acceso en línea:
- https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015143455&partnerID=40&md5=45fbaa11ab9c9f7f4ec420a5c2c377fa
https://hdl.handle.net/20.500.12494/49987
- Palabra clave:
- ACTIN FILAMENT
ARTICLE
CARCINOGENESIS
CELL PLASTICITY
EMBRYOID BODY
GENE EXPRESSION
HUMAN
HUMAN TISSUE
HYPOXIA
IMMUNOHISTOCHEMISTRY
IMMUNOREACTIVITY
METAMORPHOSIS
OXYGEN SATURATION
PHENOTYPE
PROSTATE ADENOCARCINOMA
SOMATIC CELL
TISSUE INJURY
- Rights
- openAccess
- License
- http://purl.org/coar/access_right/c_abf2
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Diaz Torres, Jairo alberto2023-05-24T16:22:00Z2023-05-24T16:22:00Z01/08/2016https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015143455&partnerID=40&md5=45fbaa11ab9c9f7f4ec420a5c2c377fa21604150https://hdl.handle.net/20.500.12494/49987Diaz Torres Jairo alberto.Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues.American Journal of Stem Cells. 2016. 5. (2):p. 53-73Emergent biological responses develop via unknown processes dependent on physical collision. In hypoxia, when the tissue architecture collapses but the geometric core is stable, actin cytoskeleton filament components emerge, revealing a hidden internal order that identifies how each molecule is reassembled into the original mold, using one common connection, i.e., a fractal self-similarity that guides the system from the beginning in reverse metamorphosis, with spontaneous self-assembly of past forms that mimics an embryoid phenotype. We captured this hidden collective filamentous assemblage in progress: Hypoxic deformed cells enter into intercellular collisions, generate migratory ejected filaments, and produce self-assembly of triangular chiral hexagon complexes; this dynamic geometry guides the microenvironment scaffold in which this biological process is incubated, recapitulating embryonic morphogenesis. In all injured tissues, especially in damaged skeletal (striated) muscle cells, visibly hypertrophic intercalated actin-myosin filaments are organized in zebra stripe pattern along the anterior-posterior axis in the interior of the cell, generating cephalic-caudal polarity segmentation, with a high selective level of immunopositivity for Actin, Alpha Skeletal Muscle antibody and for Neuron-Specific Enolase expression of ectodermal differentiation. The function of actin filaments in emergent responses to tissue injury is to reconstitute, reactivate and orchestrate cellular metamorphosis, involving the re-expression of fetal genes, providing evidence of the reverse flow of genetic information within a biological system. The resultant embryoid phenotype emerges as a microscopic fractal template copy of the organization of the whole body, likely allowing the modification and reprogramming of the phenotype of the tumor in which these structures develop, as well as establishing a reverse primordial microscopic mold to collectively re-form cellular building blocks to regenerate injured tissues. Tumorigenesis mimics a self-organizing process of early embryo development. All malignant tumors produce fetal proteins, we now know from which these proteins proceed. Embryoid-like metamorphosis phenomena would represent the anatomical and functional entity of the injury stem cell niche. The sufficiently fast identification, isolation, culture, and expansion of these self-organized structures or genetically derived products could, in our opinion, be used to develop new therapeutic strategies against cancer and in regenerative medicine. © 2016, E-Century Publishing Corporation. All rights reserved.jairo.diaz@campusucc.edu.co53-73e-Century Publishing CorporationACTIN FILAMENTARTICLECARCINOGENESISCELL PLASTICITYEMBRYOID BODYGENE EXPRESSIONHUMANHUMAN TISSUEHYPOXIAIMMUNOHISTOCHEMISTRYIMMUNOREACTIVITYMETAMORPHOSISOXYGEN SATURATIONPHENOTYPEPROSTATE ADENOCARCINOMASOMATIC CELLTISSUE INJURYHuman somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissuesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionAmerican Journal of Stem Cellsinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49987oai:repository.ucc.edu.co:20.500.12494/499872024-08-20 16:20:10.624metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com |
dc.title.spa.fl_str_mv |
Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues |
title |
Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues |
spellingShingle |
Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues ACTIN FILAMENT ARTICLE CARCINOGENESIS CELL PLASTICITY EMBRYOID BODY GENE EXPRESSION HUMAN HUMAN TISSUE HYPOXIA IMMUNOHISTOCHEMISTRY IMMUNOREACTIVITY METAMORPHOSIS OXYGEN SATURATION PHENOTYPE PROSTATE ADENOCARCINOMA SOMATIC CELL TISSUE INJURY |
title_short |
Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues |
title_full |
Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues |
title_fullStr |
Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues |
title_full_unstemmed |
Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues |
title_sort |
Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues |
dc.creator.fl_str_mv |
Diaz Torres, Jairo alberto |
dc.contributor.author.none.fl_str_mv |
Diaz Torres, Jairo alberto |
dc.subject.spa.fl_str_mv |
ACTIN FILAMENT ARTICLE CARCINOGENESIS CELL PLASTICITY EMBRYOID BODY GENE EXPRESSION HUMAN HUMAN TISSUE HYPOXIA IMMUNOHISTOCHEMISTRY IMMUNOREACTIVITY METAMORPHOSIS OXYGEN SATURATION PHENOTYPE PROSTATE ADENOCARCINOMA SOMATIC CELL TISSUE INJURY |
topic |
ACTIN FILAMENT ARTICLE CARCINOGENESIS CELL PLASTICITY EMBRYOID BODY GENE EXPRESSION HUMAN HUMAN TISSUE HYPOXIA IMMUNOHISTOCHEMISTRY IMMUNOREACTIVITY METAMORPHOSIS OXYGEN SATURATION PHENOTYPE PROSTATE ADENOCARCINOMA SOMATIC CELL TISSUE INJURY |
description |
Emergent biological responses develop via unknown processes dependent on physical collision. In hypoxia, when the tissue architecture collapses but the geometric core is stable, actin cytoskeleton filament components emerge, revealing a hidden internal order that identifies how each molecule is reassembled into the original mold, using one common connection, i.e., a fractal self-similarity that guides the system from the beginning in reverse metamorphosis, with spontaneous self-assembly of past forms that mimics an embryoid phenotype. We captured this hidden collective filamentous assemblage in progress: Hypoxic deformed cells enter into intercellular collisions, generate migratory ejected filaments, and produce self-assembly of triangular chiral hexagon complexes; this dynamic geometry guides the microenvironment scaffold in which this biological process is incubated, recapitulating embryonic morphogenesis. In all injured tissues, especially in damaged skeletal (striated) muscle cells, visibly hypertrophic intercalated actin-myosin filaments are organized in zebra stripe pattern along the anterior-posterior axis in the interior of the cell, generating cephalic-caudal polarity segmentation, with a high selective level of immunopositivity for Actin, Alpha Skeletal Muscle antibody and for Neuron-Specific Enolase expression of ectodermal differentiation. The function of actin filaments in emergent responses to tissue injury is to reconstitute, reactivate and orchestrate cellular metamorphosis, involving the re-expression of fetal genes, providing evidence of the reverse flow of genetic information within a biological system. The resultant embryoid phenotype emerges as a microscopic fractal template copy of the organization of the whole body, likely allowing the modification and reprogramming of the phenotype of the tumor in which these structures develop, as well as establishing a reverse primordial microscopic mold to collectively re-form cellular building blocks to regenerate injured tissues. Tumorigenesis mimics a self-organizing process of early embryo development. All malignant tumors produce fetal proteins, we now know from which these proteins proceed. Embryoid-like metamorphosis phenomena would represent the anatomical and functional entity of the injury stem cell niche. The sufficiently fast identification, isolation, culture, and expansion of these self-organized structures or genetically derived products could, in our opinion, be used to develop new therapeutic strategies against cancer and in regenerative medicine. © 2016, E-Century Publishing Corporation. All rights reserved. |
publishDate |
2023 |
dc.date.issued.none.fl_str_mv |
01/08/2016 |
dc.date.accessioned.none.fl_str_mv |
2023-05-24T16:22:00Z |
dc.date.available.none.fl_str_mv |
2023-05-24T16:22:00Z |
dc.type.none.fl_str_mv |
Artículo |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015143455&partnerID=40&md5=45fbaa11ab9c9f7f4ec420a5c2c377fa |
dc.identifier.issn.spa.fl_str_mv |
21604150 |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/49987 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
Diaz Torres Jairo alberto.Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues.American Journal of Stem Cells. 2016. 5. (2):p. 53-73 |
url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015143455&partnerID=40&md5=45fbaa11ab9c9f7f4ec420a5c2c377fa https://hdl.handle.net/20.500.12494/49987 |
identifier_str_mv |
21604150 Diaz Torres Jairo alberto.Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues.American Journal of Stem Cells. 2016. 5. (2):p. 53-73 |
dc.relation.ispartofjournal.spa.fl_str_mv |
American Journal of Stem Cells |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/openAccess |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_abf2 |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
http://purl.org/coar/access_right/c_abf2 |
dc.format.extent.spa.fl_str_mv |
53-73 |
dc.publisher.spa.fl_str_mv |
e-Century Publishing Corporation |
institution |
Universidad Cooperativa de Colombia |
repository.name.fl_str_mv |
Repositorio Institucional Universidad Cooperativa de Colombia |
repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
_version_ |
1814247032055922688 |