Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues

Emergent biological responses develop via unknown processes dependent on physical collision. In hypoxia, when the tissue architecture collapses but the geometric core is stable, actin cytoskeleton filament components emerge, revealing a hidden internal order that identifies how each molecule is reas...

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Autores:
Diaz Torres, Jairo alberto
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
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OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/49987
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015143455&partnerID=40&md5=45fbaa11ab9c9f7f4ec420a5c2c377fa
https://hdl.handle.net/20.500.12494/49987
Palabra clave:
ACTIN FILAMENT
ARTICLE
CARCINOGENESIS
CELL PLASTICITY
EMBRYOID BODY
GENE EXPRESSION
HUMAN
HUMAN TISSUE
HYPOXIA
IMMUNOHISTOCHEMISTRY
IMMUNOREACTIVITY
METAMORPHOSIS
OXYGEN SATURATION
PHENOTYPE
PROSTATE ADENOCARCINOMA
SOMATIC CELL
TISSUE INJURY
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openAccess
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http://purl.org/coar/access_right/c_abf2
id COOPER2_26fff545442e29112b902efaed62b812
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/49987
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Diaz Torres, Jairo alberto2023-05-24T16:22:00Z2023-05-24T16:22:00Z01/08/2016https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015143455&partnerID=40&md5=45fbaa11ab9c9f7f4ec420a5c2c377fa21604150https://hdl.handle.net/20.500.12494/49987Diaz Torres Jairo alberto.Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues.American Journal of Stem Cells. 2016. 5. (2):p. 53-73Emergent biological responses develop via unknown processes dependent on physical collision. In hypoxia, when the tissue architecture collapses but the geometric core is stable, actin cytoskeleton filament components emerge, revealing a hidden internal order that identifies how each molecule is reassembled into the original mold, using one common connection, i.e., a fractal self-similarity that guides the system from the beginning in reverse metamorphosis, with spontaneous self-assembly of past forms that mimics an embryoid phenotype. We captured this hidden collective filamentous assemblage in progress: Hypoxic deformed cells enter into intercellular collisions, generate migratory ejected filaments, and produce self-assembly of triangular chiral hexagon complexes; this dynamic geometry guides the microenvironment scaffold in which this biological process is incubated, recapitulating embryonic morphogenesis. In all injured tissues, especially in damaged skeletal (striated) muscle cells, visibly hypertrophic intercalated actin-myosin filaments are organized in zebra stripe pattern along the anterior-posterior axis in the interior of the cell, generating cephalic-caudal polarity segmentation, with a high selective level of immunopositivity for Actin, Alpha Skeletal Muscle antibody and for Neuron-Specific Enolase expression of ectodermal differentiation. The function of actin filaments in emergent responses to tissue injury is to reconstitute, reactivate and orchestrate cellular metamorphosis, involving the re-expression of fetal genes, providing evidence of the reverse flow of genetic information within a biological system. The resultant embryoid phenotype emerges as a microscopic fractal template copy of the organization of the whole body, likely allowing the modification and reprogramming of the phenotype of the tumor in which these structures develop, as well as establishing a reverse primordial microscopic mold to collectively re-form cellular building blocks to regenerate injured tissues. Tumorigenesis mimics a self-organizing process of early embryo development. All malignant tumors produce fetal proteins, we now know from which these proteins proceed. Embryoid-like metamorphosis phenomena would represent the anatomical and functional entity of the injury stem cell niche. The sufficiently fast identification, isolation, culture, and expansion of these self-organized structures or genetically derived products could, in our opinion, be used to develop new therapeutic strategies against cancer and in regenerative medicine. © 2016, E-Century Publishing Corporation. All rights reserved.jairo.diaz@campusucc.edu.co53-73e-Century Publishing CorporationACTIN FILAMENTARTICLECARCINOGENESISCELL PLASTICITYEMBRYOID BODYGENE EXPRESSIONHUMANHUMAN TISSUEHYPOXIAIMMUNOHISTOCHEMISTRYIMMUNOREACTIVITYMETAMORPHOSISOXYGEN SATURATIONPHENOTYPEPROSTATE ADENOCARCINOMASOMATIC CELLTISSUE INJURYHuman somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissuesArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionAmerican Journal of Stem Cellsinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49987oai:repository.ucc.edu.co:20.500.12494/499872024-08-20 16:20:10.624metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
title Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
spellingShingle Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
ACTIN FILAMENT
ARTICLE
CARCINOGENESIS
CELL PLASTICITY
EMBRYOID BODY
GENE EXPRESSION
HUMAN
HUMAN TISSUE
HYPOXIA
IMMUNOHISTOCHEMISTRY
IMMUNOREACTIVITY
METAMORPHOSIS
OXYGEN SATURATION
PHENOTYPE
PROSTATE ADENOCARCINOMA
SOMATIC CELL
TISSUE INJURY
title_short Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
title_full Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
title_fullStr Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
title_full_unstemmed Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
title_sort Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues
dc.creator.fl_str_mv Diaz Torres, Jairo alberto
dc.contributor.author.none.fl_str_mv Diaz Torres, Jairo alberto
dc.subject.spa.fl_str_mv ACTIN FILAMENT
ARTICLE
CARCINOGENESIS
CELL PLASTICITY
EMBRYOID BODY
GENE EXPRESSION
HUMAN
HUMAN TISSUE
HYPOXIA
IMMUNOHISTOCHEMISTRY
IMMUNOREACTIVITY
METAMORPHOSIS
OXYGEN SATURATION
PHENOTYPE
PROSTATE ADENOCARCINOMA
SOMATIC CELL
TISSUE INJURY
topic ACTIN FILAMENT
ARTICLE
CARCINOGENESIS
CELL PLASTICITY
EMBRYOID BODY
GENE EXPRESSION
HUMAN
HUMAN TISSUE
HYPOXIA
IMMUNOHISTOCHEMISTRY
IMMUNOREACTIVITY
METAMORPHOSIS
OXYGEN SATURATION
PHENOTYPE
PROSTATE ADENOCARCINOMA
SOMATIC CELL
TISSUE INJURY
description Emergent biological responses develop via unknown processes dependent on physical collision. In hypoxia, when the tissue architecture collapses but the geometric core is stable, actin cytoskeleton filament components emerge, revealing a hidden internal order that identifies how each molecule is reassembled into the original mold, using one common connection, i.e., a fractal self-similarity that guides the system from the beginning in reverse metamorphosis, with spontaneous self-assembly of past forms that mimics an embryoid phenotype. We captured this hidden collective filamentous assemblage in progress: Hypoxic deformed cells enter into intercellular collisions, generate migratory ejected filaments, and produce self-assembly of triangular chiral hexagon complexes; this dynamic geometry guides the microenvironment scaffold in which this biological process is incubated, recapitulating embryonic morphogenesis. In all injured tissues, especially in damaged skeletal (striated) muscle cells, visibly hypertrophic intercalated actin-myosin filaments are organized in zebra stripe pattern along the anterior-posterior axis in the interior of the cell, generating cephalic-caudal polarity segmentation, with a high selective level of immunopositivity for Actin, Alpha Skeletal Muscle antibody and for Neuron-Specific Enolase expression of ectodermal differentiation. The function of actin filaments in emergent responses to tissue injury is to reconstitute, reactivate and orchestrate cellular metamorphosis, involving the re-expression of fetal genes, providing evidence of the reverse flow of genetic information within a biological system. The resultant embryoid phenotype emerges as a microscopic fractal template copy of the organization of the whole body, likely allowing the modification and reprogramming of the phenotype of the tumor in which these structures develop, as well as establishing a reverse primordial microscopic mold to collectively re-form cellular building blocks to regenerate injured tissues. Tumorigenesis mimics a self-organizing process of early embryo development. All malignant tumors produce fetal proteins, we now know from which these proteins proceed. Embryoid-like metamorphosis phenomena would represent the anatomical and functional entity of the injury stem cell niche. The sufficiently fast identification, isolation, culture, and expansion of these self-organized structures or genetically derived products could, in our opinion, be used to develop new therapeutic strategies against cancer and in regenerative medicine. © 2016, E-Century Publishing Corporation. All rights reserved.
publishDate 2023
dc.date.issued.none.fl_str_mv 01/08/2016
dc.date.accessioned.none.fl_str_mv 2023-05-24T16:22:00Z
dc.date.available.none.fl_str_mv 2023-05-24T16:22:00Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015143455&partnerID=40&md5=45fbaa11ab9c9f7f4ec420a5c2c377fa
dc.identifier.issn.spa.fl_str_mv 21604150
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/49987
dc.identifier.bibliographicCitation.spa.fl_str_mv Diaz Torres Jairo alberto.Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues.American Journal of Stem Cells. 2016. 5. (2):p. 53-73
url https://www.scopus.com/inward/record.uri?eid=2-s2.0-85015143455&partnerID=40&md5=45fbaa11ab9c9f7f4ec420a5c2c377fa
https://hdl.handle.net/20.500.12494/49987
identifier_str_mv 21604150
Diaz Torres Jairo alberto.Human somatic cells acquire the plasticity to generate embryoid-like metamorphosis via the actin cytoskeleton in injured tissues.American Journal of Stem Cells. 2016. 5. (2):p. 53-73
dc.relation.ispartofjournal.spa.fl_str_mv American Journal of Stem Cells
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 53-73
dc.publisher.spa.fl_str_mv e-Century Publishing Corporation
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814247032055922688