NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region

Objective: To study the NAT 2 gene polymorphisms 481T, 590A and 857A in the Chimila, Wiwa and Wayuu indigenous groups of the Colombian Caribbean to determine the frequencies of the alleles NAT2*4, NAT2*5, NAT2*6, and NAT2*7 and to determine the types of acetylators present in these populations. Meth...

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Autores:
Arias I.
Lecompte N.
Visbal L.
Curiel I.
Hernandez Aguirre, Enio
Garavito P.
Silvera-Redondo C.
Tipo de recurso:
Article of journal
Fecha de publicación:
2023
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/49695
Acceso en línea:
https://doi.org/10.25100/cm.v45i4.1563
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921926737&partnerID=40&md5=d30772305d3e69be448b6566367ee5de
https://hdl.handle.net/20.500.12494/49695
Palabra clave:
ACETYLATION
ACETYLATOR PHENOTYPE
ALLELE
ALLELES
AMERICAN INDIAN
ARTICLE
ARYLAMINE ACETYLTRANSFERASE
ARYLAMINE N-ACETYLTRANSFERASE
CARIBBEAN
COLOMBIA
COLOMBIAN
FEMALE
GENE
GENE FREQUENCY
GENETIC VARIABILITY
GENETICS
GENOMIC DNA
HAPLOTYPE
HUMAN
HUMANS
INDIANS, SOUTH AMERICAN
MALE
NAT2 GENE
NAT2 PROTEIN, HUMAN
PHARMACOGENETICS
POLYMORPHISM, SINGLE NUCLEOTIDE
REAL TIME POLYMERASE CHAIN REACTION
REAL-TIME POLYMERASE CHAIN REACTION
SINGLE NUCLEOTIDE POLYMORPHISM
Rights
openAccess
License
http://purl.org/coar/access_right/c_abf2
id COOPER2_1ee1c3f7034793a46728e097740b8499
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/49695
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Arias I.Lecompte N.Visbal L.Curiel I.Hernandez Aguirre, EnioGaravito P.Silvera-Redondo C.2023-05-24T16:21:38Z2023-05-24T16:21:38Z01/01/2014https://doi.org/10.25100/cm.v45i4.1563https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921926737&partnerID=40&md5=d30772305d3e69be448b6566367ee5de16579534https://hdl.handle.net/20.500.12494/49695Arias I.,Lecompte N.,Visbal L.,Curiel I.,Hernandez Aguirre Enio,Garavito P.,Silvera-Redondo C..NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region.COLOMB MEDICA. 2014. 45. (4):p. 148-153Objective: To study the NAT 2 gene polymorphisms 481T, 590A and 857A in the Chimila, Wiwa and Wayuu indigenous groups of the Colombian Caribbean to determine the frequencies of the alleles NAT2*4, NAT2*5, NAT2*6, and NAT2*7 and to determine the types of acetylators present in these populations. Methods: A total of 202 subjects were studied: 47 Chimila, 55 Wiwa, and 100 Wayuu. Te polymorphisms were identifed using a real-time PCR method for allelic discrimination designed using Taqman of Applied Biosystems. Results: Te following alleles were found at the highest frequency in the following groups: the NAT2*4 allele (wild type) in the Wayuu group (55.3%), the NAT2*5 allele in the Wiwa group (34.5%), and the NAT2*7 allele in the Chimila group (24.2%). A higher frequency of the rapid acetylator status was found in the Wayuu group (31.3%) and Chimila group (29.5%) compared with the Wiwa group (12.7%). Te intermediate acetylator status distribution was very similar in all three groups, and the frequency of the slow acetylator status was higher in the Wiwa group (32.7%) compared with the Chimila and Wayuu groups (20.5% and 21.2%, respectively). Conclusion: Te results demonstrated the allelic distribution and pharmacogenetic diferences of the three groups studied and revealed the most frequent acetylator status and phenotype. Because of the high prevalence of slow acetylators, a greater incidence of tuberculosis (TB) drug-induced hepatotoxicity is predicted in these populations, with a higher frequency in the Wiwa group. © 2014 Universidad del Valle.148-153Facultad de Salud de la Universidad del ValleACETYLATIONACETYLATOR PHENOTYPEALLELEALLELESAMERICAN INDIANARTICLEARYLAMINE ACETYLTRANSFERASEARYLAMINE N-ACETYLTRANSFERASECARIBBEANCOLOMBIACOLOMBIANFEMALEGENEGENE FREQUENCYGENETIC VARIABILITYGENETICSGENOMIC DNAHAPLOTYPEHUMANHUMANSINDIANS, SOUTH AMERICANMALENAT2 GENENAT2 PROTEIN, HUMANPHARMACOGENETICSPOLYMORPHISM, SINGLE NUCLEOTIDEREAL TIME POLYMERASE CHAIN REACTIONREAL-TIME POLYMERASE CHAIN REACTIONSINGLE NUCLEOTIDE POLYMORPHISMNAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast regionArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionCOLOMB MEDICAinfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2Publication20.500.12494/49695oai:repository.ucc.edu.co:20.500.12494/496952024-08-20 16:23:27.868metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region
title NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region
spellingShingle NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region
ACETYLATION
ACETYLATOR PHENOTYPE
ALLELE
ALLELES
AMERICAN INDIAN
ARTICLE
ARYLAMINE ACETYLTRANSFERASE
ARYLAMINE N-ACETYLTRANSFERASE
CARIBBEAN
COLOMBIA
COLOMBIAN
FEMALE
GENE
GENE FREQUENCY
GENETIC VARIABILITY
GENETICS
GENOMIC DNA
HAPLOTYPE
HUMAN
HUMANS
INDIANS, SOUTH AMERICAN
MALE
NAT2 GENE
NAT2 PROTEIN, HUMAN
PHARMACOGENETICS
POLYMORPHISM, SINGLE NUCLEOTIDE
REAL TIME POLYMERASE CHAIN REACTION
REAL-TIME POLYMERASE CHAIN REACTION
SINGLE NUCLEOTIDE POLYMORPHISM
title_short NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region
title_full NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region
title_fullStr NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region
title_full_unstemmed NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region
title_sort NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region
dc.creator.fl_str_mv Arias I.
Lecompte N.
Visbal L.
Curiel I.
Hernandez Aguirre, Enio
Garavito P.
Silvera-Redondo C.
dc.contributor.author.none.fl_str_mv Arias I.
Lecompte N.
Visbal L.
Curiel I.
Hernandez Aguirre, Enio
Garavito P.
Silvera-Redondo C.
dc.subject.spa.fl_str_mv ACETYLATION
ACETYLATOR PHENOTYPE
ALLELE
ALLELES
AMERICAN INDIAN
ARTICLE
ARYLAMINE ACETYLTRANSFERASE
ARYLAMINE N-ACETYLTRANSFERASE
CARIBBEAN
COLOMBIA
COLOMBIAN
FEMALE
GENE
GENE FREQUENCY
GENETIC VARIABILITY
GENETICS
GENOMIC DNA
HAPLOTYPE
HUMAN
HUMANS
INDIANS, SOUTH AMERICAN
MALE
NAT2 GENE
NAT2 PROTEIN, HUMAN
PHARMACOGENETICS
POLYMORPHISM, SINGLE NUCLEOTIDE
REAL TIME POLYMERASE CHAIN REACTION
REAL-TIME POLYMERASE CHAIN REACTION
SINGLE NUCLEOTIDE POLYMORPHISM
topic ACETYLATION
ACETYLATOR PHENOTYPE
ALLELE
ALLELES
AMERICAN INDIAN
ARTICLE
ARYLAMINE ACETYLTRANSFERASE
ARYLAMINE N-ACETYLTRANSFERASE
CARIBBEAN
COLOMBIA
COLOMBIAN
FEMALE
GENE
GENE FREQUENCY
GENETIC VARIABILITY
GENETICS
GENOMIC DNA
HAPLOTYPE
HUMAN
HUMANS
INDIANS, SOUTH AMERICAN
MALE
NAT2 GENE
NAT2 PROTEIN, HUMAN
PHARMACOGENETICS
POLYMORPHISM, SINGLE NUCLEOTIDE
REAL TIME POLYMERASE CHAIN REACTION
REAL-TIME POLYMERASE CHAIN REACTION
SINGLE NUCLEOTIDE POLYMORPHISM
description Objective: To study the NAT 2 gene polymorphisms 481T, 590A and 857A in the Chimila, Wiwa and Wayuu indigenous groups of the Colombian Caribbean to determine the frequencies of the alleles NAT2*4, NAT2*5, NAT2*6, and NAT2*7 and to determine the types of acetylators present in these populations. Methods: A total of 202 subjects were studied: 47 Chimila, 55 Wiwa, and 100 Wayuu. Te polymorphisms were identifed using a real-time PCR method for allelic discrimination designed using Taqman of Applied Biosystems. Results: Te following alleles were found at the highest frequency in the following groups: the NAT2*4 allele (wild type) in the Wayuu group (55.3%), the NAT2*5 allele in the Wiwa group (34.5%), and the NAT2*7 allele in the Chimila group (24.2%). A higher frequency of the rapid acetylator status was found in the Wayuu group (31.3%) and Chimila group (29.5%) compared with the Wiwa group (12.7%). Te intermediate acetylator status distribution was very similar in all three groups, and the frequency of the slow acetylator status was higher in the Wiwa group (32.7%) compared with the Chimila and Wayuu groups (20.5% and 21.2%, respectively). Conclusion: Te results demonstrated the allelic distribution and pharmacogenetic diferences of the three groups studied and revealed the most frequent acetylator status and phenotype. Because of the high prevalence of slow acetylators, a greater incidence of tuberculosis (TB) drug-induced hepatotoxicity is predicted in these populations, with a higher frequency in the Wiwa group. © 2014 Universidad del Valle.
publishDate 2023
dc.date.issued.none.fl_str_mv 01/01/2014
dc.date.accessioned.none.fl_str_mv 2023-05-24T16:21:38Z
dc.date.available.none.fl_str_mv 2023-05-24T16:21:38Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.25100/cm.v45i4.1563
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921926737&partnerID=40&md5=d30772305d3e69be448b6566367ee5de
dc.identifier.issn.spa.fl_str_mv 16579534
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/49695
dc.identifier.bibliographicCitation.spa.fl_str_mv Arias I.,Lecompte N.,Visbal L.,Curiel I.,Hernandez Aguirre Enio,Garavito P.,Silvera-Redondo C..NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region.COLOMB MEDICA. 2014. 45. (4):p. 148-153
url https://doi.org/10.25100/cm.v45i4.1563
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921926737&partnerID=40&md5=d30772305d3e69be448b6566367ee5de
https://hdl.handle.net/20.500.12494/49695
identifier_str_mv 16579534
Arias I.,Lecompte N.,Visbal L.,Curiel I.,Hernandez Aguirre Enio,Garavito P.,Silvera-Redondo C..NAT2 gene polymorphisms in three indigenous groups in the Colombian Caribbean Coast region.COLOMB MEDICA. 2014. 45. (4):p. 148-153
dc.relation.ispartofjournal.spa.fl_str_mv COLOMB MEDICA
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_abf2
dc.format.extent.spa.fl_str_mv 148-153
dc.publisher.spa.fl_str_mv Facultad de Salud de la Universidad del Valle
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814247349083439104

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