Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune

El material particulado (PM, del inglés Particulate Matter) es un contaminante del aire que se clasifica según su diámetro aerodinámico en partículas con diámetro menor a 10 µm (PM10), diámetro menor a 2,5 µm (PM2.5) y las partículas ultra-finas con un diámetro menor a 0,1 µm (PM0.1). El PM10 se alo...

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Autores:
Cano-Granada, Danna
Ramírez-Ramírez, Mariana
Gómez Gallego, Diana Maryory
Hernández López, Juan Carlos
Tipo de recurso:
Article of investigation
Fecha de publicación:
2022
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/45952
Acceso en línea:
https://hdl.handle.net/20.500.12494/45952
Palabra clave:
Contaminación del aire
material particulado
endotelio
epitelio
inflamación
estrés oxidativo
mutagenicidad
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openAccess
License
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id COOPER2_1e3c3ccd5cc80aeb521a9fec7cf19ce3
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/45952
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune
title Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune
spellingShingle Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune
Contaminación del aire
material particulado
endotelio
epitelio
inflamación
estrés oxidativo
mutagenicidad
title_short Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune
title_full Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune
title_fullStr Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune
title_full_unstemmed Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune
title_sort Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune
dc.creator.fl_str_mv Cano-Granada, Danna
Ramírez-Ramírez, Mariana
Gómez Gallego, Diana Maryory
Hernández López, Juan Carlos
dc.contributor.author.none.fl_str_mv Cano-Granada, Danna
Ramírez-Ramírez, Mariana
Gómez Gallego, Diana Maryory
Hernández López, Juan Carlos
dc.subject.spa.fl_str_mv Contaminación del aire
material particulado
endotelio
epitelio
inflamación
estrés oxidativo
mutagenicidad
topic Contaminación del aire
material particulado
endotelio
epitelio
inflamación
estrés oxidativo
mutagenicidad
description El material particulado (PM, del inglés Particulate Matter) es un contaminante del aire que se clasifica según su diámetro aerodinámico en partículas con diámetro menor a 10 µm (PM10), diámetro menor a 2,5 µm (PM2.5) y las partículas ultra-finas con un diámetro menor a 0,1 µm (PM0.1). El PM10 se aloja en el sistema respiratorio, mientras que el PM2.5 y PM0.1 tienen la capacidad de pasar a la circulación, por lo que puede generar alteraciones sistémicas. Aunque se ha documentado varias enfermedades que se asocian a la exposición a PM, como respiratorias, cardiovasculares, y en el sistema nervioso central, que ocasionan en el mundo 4,2 millones de muertes prematuras al año. Hay pocas revisiones que aborden los mecanismos celulares y moleculares en células epiteliales y endoteliales de los tejidos expuestos al PM, que puedan ocasionar dichas enfermedades, siendo este el objetivo de la presente revisión. Para esta, se realizó una búsqueda en la base de datos del NCBI y Google Scholar enfocada en publicaciones científicas que abordaran la expresión de moléculas pro-inflamatorias, moléculas de adhesión y radicales oxidativos, entre otros, y su relación con los efectos ocasionados por el PM. Entre los principales hallazgos se destaca el aumento de citoquinas pro-inflamatorias y disfunción en los componentes de la respuesta inmune; la formación de especies reactivas del oxígeno; cambios en la función epitelial y endotelial, evidenciados por la alteración de la expresión de moléculas de adhesión; así como el incremento de moléculas implicadas en la coagulación. Se requieren estudios complementarios que contribuyan al entendimiento de los efectos moleculares asociados con los efectos deletéreos en la salud y el futuro planteamiento de estrategias para atenuar esta respuesta.
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2022-07-28T19:50:36Z
dc.date.available.none.fl_str_mv 2022-07-28T19:50:36Z
dc.date.issued.none.fl_str_mv 2022-02-15
dc.type.none.fl_str_mv Artículos Científicos
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.spa.fl_str_mv 10.21931/RB/2022.07.01.4
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/45952
dc.identifier.bibliographicCitation.spa.fl_str_mv Cano-Granda D V, Ramírez-Ramírez M, Gómez-Gallego D M, Hernandez JC. Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune. Revis Bionatura 2022;7(1). 4. http://dx.doi.org/10.21931/RB/2022.07.01.4 http://dx.doi. org/10.21931/RB/2022.07.01.4
identifier_str_mv 10.21931/RB/2022.07.01.4
Cano-Granda D V, Ramírez-Ramírez M, Gómez-Gallego D M, Hernandez JC. Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune. Revis Bionatura 2022;7(1). 4. http://dx.doi.org/10.21931/RB/2022.07.01.4 http://dx.doi. org/10.21931/RB/2022.07.01.4
url https://hdl.handle.net/20.500.12494/45952
dc.relation.isversionof.spa.fl_str_mv https://www.revistabionatura.com/files/2022.07.01.4.pdf
dc.relation.ispartofjournal.spa.fl_str_mv Bionatura
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spelling Cano-Granada, DannaRamírez-Ramírez, MarianaGómez Gallego, Diana Maryory Hernández López, Juan Carlos 7/12022-07-28T19:50:36Z2022-07-28T19:50:36Z2022-02-1510.21931/RB/2022.07.01.4https://hdl.handle.net/20.500.12494/45952Cano-Granda D V, Ramírez-Ramírez M, Gómez-Gallego D M, Hernandez JC. Efectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmune. Revis Bionatura 2022;7(1). 4. http://dx.doi.org/10.21931/RB/2022.07.01.4 http://dx.doi. org/10.21931/RB/2022.07.01.4El material particulado (PM, del inglés Particulate Matter) es un contaminante del aire que se clasifica según su diámetro aerodinámico en partículas con diámetro menor a 10 µm (PM10), diámetro menor a 2,5 µm (PM2.5) y las partículas ultra-finas con un diámetro menor a 0,1 µm (PM0.1). El PM10 se aloja en el sistema respiratorio, mientras que el PM2.5 y PM0.1 tienen la capacidad de pasar a la circulación, por lo que puede generar alteraciones sistémicas. Aunque se ha documentado varias enfermedades que se asocian a la exposición a PM, como respiratorias, cardiovasculares, y en el sistema nervioso central, que ocasionan en el mundo 4,2 millones de muertes prematuras al año. Hay pocas revisiones que aborden los mecanismos celulares y moleculares en células epiteliales y endoteliales de los tejidos expuestos al PM, que puedan ocasionar dichas enfermedades, siendo este el objetivo de la presente revisión. Para esta, se realizó una búsqueda en la base de datos del NCBI y Google Scholar enfocada en publicaciones científicas que abordaran la expresión de moléculas pro-inflamatorias, moléculas de adhesión y radicales oxidativos, entre otros, y su relación con los efectos ocasionados por el PM. Entre los principales hallazgos se destaca el aumento de citoquinas pro-inflamatorias y disfunción en los componentes de la respuesta inmune; la formación de especies reactivas del oxígeno; cambios en la función epitelial y endotelial, evidenciados por la alteración de la expresión de moléculas de adhesión; así como el incremento de moléculas implicadas en la coagulación. Se requieren estudios complementarios que contribuyan al entendimiento de los efectos moleculares asociados con los efectos deletéreos en la salud y el futuro planteamiento de estrategias para atenuar esta respuesta.https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000283088http://orcid.org/0000-0002-9200-5698https://scienti.colciencias.gov.co/gruplac/jsp/visualiza/visualizagr.jsp?nro=00000000011355juankhernandez@gmail.com1-7Universidad Cooperativa de Colombia, Facultad de Ciencias de la Salud, Programa de Medicina, Medellín y Envigado, Colombia, 00000MedicinaMedellínhttps://www.revistabionatura.com/files/2022.07.01.4.pdfBionaturaNAAQS Table [Internet]. Available from: https://www.epa.gov/ criteria-air-pollutants/naaqs-tableConceptos básicos sobre el material particulado (PM, por sus siglas en inglés) [Internet]. 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Rev Med. 2013;Contaminación del airematerial particuladoendotelioepitelioinflamaciónestrés oxidativomutagenicidadEfectos del material particulado sobre las células endoteliales, epiteliales y del sistema inmuneArtículos Científicoshttp://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionAtribucióninfo:eu-repo/semantics/openAccesshttp://purl.org/coar/access_right/c_abf2PublicationORIGINALRevision Moleculas Adhesion 2022.pdfRevision Moleculas Adhesion 2022.pdfapplication/pdf363922https://repository.ucc.edu.co/bitstreams/f0c3479b-c352-4790-b335-14a8d5c3c9d2/download0c1605e1b765eae9d9b8579dbd820abfMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.ucc.edu.co/bitstreams/8638a96c-0923-43b8-9c00-8cf8f7356aae/download8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILRevision Moleculas Adhesion 2022.pdf.jpgRevision Moleculas Adhesion 2022.pdf.jpgGenerated Thumbnailimage/jpeg4981https://repository.ucc.edu.co/bitstreams/701cbb00-bda7-4ffe-9d92-b8b8127b2867/download7347459ca20c2af837ea06fe0da157fdMD53TEXTRevision Moleculas Adhesion 2022.pdf.txtRevision Moleculas Adhesion 2022.pdf.txtExtracted texttext/plain48603https://repository.ucc.edu.co/bitstreams/0c5deec1-9d67-4eae-9a87-1efd6799b2ba/download94481b66b9dcbdaed731cdf4848dc286MD5420.500.12494/45952oai:repository.ucc.edu.co:20.500.12494/459522024-08-20 16:24:09.076open.accesshttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.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