Sulfasalazine as an Immunomodulator of the Inflammatory Process during HIV-1 Infection.

HIV-1 induces an uncontrolled inflammatory response of several immune components, such as inflammasomes. These molecular complexes, associated with Toll-like receptor (TLR) activity, induce the maturation and release of IL-1 and IL-18 and eventually induce pyroptosis. It has been previously demonstrated that HIV induces inflammasome activation, which is significantly lower in the gastrointestinal tissue and blood from people living with HIV-1 with spontaneous control of viral replication. Therefore, immunomodulatory agents could be useful in improving HIV prognosis.

• Autores: Feria Garzón, M. G.; Rugeles, M. T.; Hernández López, Juan Carlos; Lujan, J. A.; Taborda, N. A
• Tipo de recurso: Article of journal
• Fecha de publicación: 2023
• Institución: Universidad Cooperativa de Colombia
• Repositorio: Repositorio UCC
• OAI Identifier: oai:repository.ucc.edu.co:20.500.12494/50852
• Acceso en línea: https://doi.org/10.3390/ijms20184476; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85072150393&doi=10.3390%2fijms20184476&partnerID=40&md5=6b30345a684c5d474f3c2271bcde9352; https://hdl.handle.net/20.500.12494/50852
• Palabra clave: HIV; INFLAMMASOMES; INFLAMMATION; SULFASALAZINE; TOLL-LIKE RECEPTORS
• Rights: openAccess
• License: http://purl.org/coar/access_right/c_abf2