Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression
Introduction: High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been...
- Autores:
-
Marin Palma, Leidy Damariz
Castro G.A.
Cardona Arias, Jaiberth Antonio
Urcuqui-Inchima S.
Hernández López, Juan Carlos
- Tipo de recurso:
- Article of journal
- Fecha de publicación:
- 2018
- Institución:
- Universidad Cooperativa de Colombia
- Repositorio:
- Repositorio UCC
- Idioma:
- OAI Identifier:
- oai:repository.ucc.edu.co:20.500.12494/42723
- Palabra clave:
- Acquired immunodeficiency syndrome
C-reactive protein
CD4+ T-cell count
High-density lipoproteins
Human immunodeficiency virus type 1
Inflammasomes
Inflammation
NLRP3
- Rights
- closedAccess
- License
- http://purl.org/coar/access_right/c_14cb
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Marin Palma, Leidy DamarizCastro G.A.Cardona Arias, Jaiberth AntonioUrcuqui-Inchima S.Hernández López, Juan Carlos 2021-12-16T22:16:28Z2021-12-16T22:16:28Z2018https://doi.org/10.5281/zenodo.374010516643224https://hdl.handle.net/20.500.12494/42723Marín D,Castro GA,Cardona JA,Urcuqui S,Hernandez JC. Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression. FRONT IMMUNOL. 2018. 9. 1350. .Introduction: High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activated during human immunodeficiency virus type 1 (HIV-1) infection, thus contributing to immune hyperactivation, which is the main pathogenic mechanism of HIV-1 progression. However, the relationship between HDL and inflammasomes in the context of HIV-1 infection is unclear. Therefore, this research aims to explore the association between HDL and the components of the inflammatory response during HIV-1 infection. Methodology: A cross-sectional study, including 36 HIV-1-infected individuals without antiretroviral treatment and 36 healthy controls matched by sex and age, was conducted. Viral load, CD4+ T-cell counts, serum HDL, and C-reactive protein (CRP) were quantified. Serum cytokine levels, including IL-1ß, IL-6, and IL-18, were assessed by ELISA. The inflammasome-related genes in peripheral blood mononuclear cells were determined by quantitative real-time PCR. Results: HIV-1-infected individuals showed a significant decrease in HDL levels, particularly those subjects with higher viral load and lower CD4+ T-cell counts. Moreover, upregulation of inflammasome-related genes (NLRP3, AIM2, ASC, IL-1ß, and IL-18) was observed, notably in those HIV-1-infected individuals with higher viral loads (above 5,000 copies/mL). Serum levels of IL-6 and CRP were also elevated in HIV-1-infected individuals. Significant negative correlations between HDL and the mRNA of NLRP3, AIM2, ASC, IL-1ß, and IL-18, as well as viral load and CRP were observed in HIV-1-infected individuals. Likewise, a significant positive correlation between HDL and CD4+ T-cell counts was found. Conclusion: In summary, our results indicate that HDL might modulate the expression of several key components of the inflammasomes during HIV-1 infection, suggesting a novel role of HDL in modifying the inflammatory state and consequently, the progression of HIV-1 infection. © 2018 Marin-Palma, Castro, Cardona-Arias, Urcuqui-Inchima and Hernandez.0000-0002-7101-929Xjaiberth.cardona@campusucc.edu.co-Frontiers Media S.A.Acquired immunodeficiency syndromeC-reactive proteinCD4+ T-cell countHigh-density lipoproteinsHuman immunodeficiency virus type 1InflammasomesInflammationNLRP3Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progressionArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionFRONT IMMUNOLinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/42723oai:repository.ucc.edu.co:20.500.12494/427232024-08-20 16:14:30.294metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com |
dc.title.spa.fl_str_mv |
Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression |
title |
Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression |
spellingShingle |
Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression Acquired immunodeficiency syndrome C-reactive protein CD4+ T-cell count High-density lipoproteins Human immunodeficiency virus type 1 Inflammasomes Inflammation NLRP3 |
title_short |
Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression |
title_full |
Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression |
title_fullStr |
Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression |
title_full_unstemmed |
Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression |
title_sort |
Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression |
dc.creator.fl_str_mv |
Marin Palma, Leidy Damariz Castro G.A. Cardona Arias, Jaiberth Antonio Urcuqui-Inchima S. Hernández López, Juan Carlos |
dc.contributor.author.none.fl_str_mv |
Marin Palma, Leidy Damariz Castro G.A. Cardona Arias, Jaiberth Antonio Urcuqui-Inchima S. Hernández López, Juan Carlos |
dc.subject.spa.fl_str_mv |
Acquired immunodeficiency syndrome C-reactive protein CD4+ T-cell count High-density lipoproteins Human immunodeficiency virus type 1 Inflammasomes Inflammation NLRP3 |
topic |
Acquired immunodeficiency syndrome C-reactive protein CD4+ T-cell count High-density lipoproteins Human immunodeficiency virus type 1 Inflammasomes Inflammation NLRP3 |
description |
Introduction: High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activated during human immunodeficiency virus type 1 (HIV-1) infection, thus contributing to immune hyperactivation, which is the main pathogenic mechanism of HIV-1 progression. However, the relationship between HDL and inflammasomes in the context of HIV-1 infection is unclear. Therefore, this research aims to explore the association between HDL and the components of the inflammatory response during HIV-1 infection. Methodology: A cross-sectional study, including 36 HIV-1-infected individuals without antiretroviral treatment and 36 healthy controls matched by sex and age, was conducted. Viral load, CD4+ T-cell counts, serum HDL, and C-reactive protein (CRP) were quantified. Serum cytokine levels, including IL-1ß, IL-6, and IL-18, were assessed by ELISA. The inflammasome-related genes in peripheral blood mononuclear cells were determined by quantitative real-time PCR. Results: HIV-1-infected individuals showed a significant decrease in HDL levels, particularly those subjects with higher viral load and lower CD4+ T-cell counts. Moreover, upregulation of inflammasome-related genes (NLRP3, AIM2, ASC, IL-1ß, and IL-18) was observed, notably in those HIV-1-infected individuals with higher viral loads (above 5,000 copies/mL). Serum levels of IL-6 and CRP were also elevated in HIV-1-infected individuals. Significant negative correlations between HDL and the mRNA of NLRP3, AIM2, ASC, IL-1ß, and IL-18, as well as viral load and CRP were observed in HIV-1-infected individuals. Likewise, a significant positive correlation between HDL and CD4+ T-cell counts was found. Conclusion: In summary, our results indicate that HDL might modulate the expression of several key components of the inflammasomes during HIV-1 infection, suggesting a novel role of HDL in modifying the inflammatory state and consequently, the progression of HIV-1 infection. © 2018 Marin-Palma, Castro, Cardona-Arias, Urcuqui-Inchima and Hernandez. |
publishDate |
2018 |
dc.date.issued.none.fl_str_mv |
2018 |
dc.date.accessioned.none.fl_str_mv |
2021-12-16T22:16:28Z |
dc.date.available.none.fl_str_mv |
2021-12-16T22:16:28Z |
dc.type.none.fl_str_mv |
Artículo |
dc.type.coar.fl_str_mv |
http://purl.org/coar/resource_type/c_2df8fbb1 |
dc.type.coar.none.fl_str_mv |
http://purl.org/coar/resource_type/c_6501 |
dc.type.coarversion.none.fl_str_mv |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
dc.type.driver.none.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.redcol.none.fl_str_mv |
http://purl.org/redcol/resource_type/ART |
dc.type.version.none.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
http://purl.org/coar/resource_type/c_6501 |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
https://doi.org/10.5281/zenodo.3740105 |
dc.identifier.issn.spa.fl_str_mv |
16643224 |
dc.identifier.uri.none.fl_str_mv |
https://hdl.handle.net/20.500.12494/42723 |
dc.identifier.bibliographicCitation.spa.fl_str_mv |
Marín D,Castro GA,Cardona JA,Urcuqui S,Hernandez JC. Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression. FRONT IMMUNOL. 2018. 9. 1350. . |
url |
https://doi.org/10.5281/zenodo.3740105 https://hdl.handle.net/20.500.12494/42723 |
identifier_str_mv |
16643224 Marín D,Castro GA,Cardona JA,Urcuqui S,Hernandez JC. Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression. FRONT IMMUNOL. 2018. 9. 1350. . |
dc.relation.ispartofjournal.spa.fl_str_mv |
FRONT IMMUNOL |
dc.rights.accessrights.none.fl_str_mv |
info:eu-repo/semantics/closedAccess |
dc.rights.coar.none.fl_str_mv |
http://purl.org/coar/access_right/c_14cb |
eu_rights_str_mv |
closedAccess |
rights_invalid_str_mv |
http://purl.org/coar/access_right/c_14cb |
dc.format.extent.spa.fl_str_mv |
- |
dc.publisher.spa.fl_str_mv |
Frontiers Media S.A. |
institution |
Universidad Cooperativa de Colombia |
repository.name.fl_str_mv |
Repositorio Institucional Universidad Cooperativa de Colombia |
repository.mail.fl_str_mv |
bdigital@metabiblioteca.com |
_version_ |
1818158383386066944 |