Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression

Introduction: High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been...

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Autores:
Marin Palma, Leidy Damariz
Castro G.A.
Cardona Arias, Jaiberth Antonio
Urcuqui-Inchima S.
Hernández López, Juan Carlos
Tipo de recurso:
Article of journal
Fecha de publicación:
2018
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
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OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/42723
Acceso en línea:
https://doi.org/10.5281/zenodo.3740105
https://hdl.handle.net/20.500.12494/42723
Palabra clave:
Acquired immunodeficiency syndrome
C-reactive protein
CD4+ T-cell count
High-density lipoproteins
Human immunodeficiency virus type 1
Inflammasomes
Inflammation
NLRP3
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closedAccess
License
http://purl.org/coar/access_right/c_14cb
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oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/42723
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Marin Palma, Leidy DamarizCastro G.A.Cardona Arias, Jaiberth AntonioUrcuqui-Inchima S.Hernández López, Juan Carlos 2021-12-16T22:16:28Z2021-12-16T22:16:28Z2018https://doi.org/10.5281/zenodo.374010516643224https://hdl.handle.net/20.500.12494/42723Marín D,Castro GA,Cardona JA,Urcuqui S,Hernandez JC. Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression. FRONT IMMUNOL. 2018. 9. 1350. .Introduction: High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activated during human immunodeficiency virus type 1 (HIV-1) infection, thus contributing to immune hyperactivation, which is the main pathogenic mechanism of HIV-1 progression. However, the relationship between HDL and inflammasomes in the context of HIV-1 infection is unclear. Therefore, this research aims to explore the association between HDL and the components of the inflammatory response during HIV-1 infection. Methodology: A cross-sectional study, including 36 HIV-1-infected individuals without antiretroviral treatment and 36 healthy controls matched by sex and age, was conducted. Viral load, CD4+ T-cell counts, serum HDL, and C-reactive protein (CRP) were quantified. Serum cytokine levels, including IL-1ß, IL-6, and IL-18, were assessed by ELISA. The inflammasome-related genes in peripheral blood mononuclear cells were determined by quantitative real-time PCR. Results: HIV-1-infected individuals showed a significant decrease in HDL levels, particularly those subjects with higher viral load and lower CD4+ T-cell counts. Moreover, upregulation of inflammasome-related genes (NLRP3, AIM2, ASC, IL-1ß, and IL-18) was observed, notably in those HIV-1-infected individuals with higher viral loads (above 5,000 copies/mL). Serum levels of IL-6 and CRP were also elevated in HIV-1-infected individuals. Significant negative correlations between HDL and the mRNA of NLRP3, AIM2, ASC, IL-1ß, and IL-18, as well as viral load and CRP were observed in HIV-1-infected individuals. Likewise, a significant positive correlation between HDL and CD4+ T-cell counts was found. Conclusion: In summary, our results indicate that HDL might modulate the expression of several key components of the inflammasomes during HIV-1 infection, suggesting a novel role of HDL in modifying the inflammatory state and consequently, the progression of HIV-1 infection. © 2018 Marin-Palma, Castro, Cardona-Arias, Urcuqui-Inchima and Hernandez.0000-0002-7101-929Xjaiberth.cardona@campusucc.edu.co-Frontiers Media S.A.Acquired immunodeficiency syndromeC-reactive proteinCD4+ T-cell countHigh-density lipoproteinsHuman immunodeficiency virus type 1InflammasomesInflammationNLRP3Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progressionArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionFRONT IMMUNOLinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/42723oai:repository.ucc.edu.co:20.500.12494/427232024-08-20 16:14:30.294metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression
title Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression
spellingShingle Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression
Acquired immunodeficiency syndrome
C-reactive protein
CD4+ T-cell count
High-density lipoproteins
Human immunodeficiency virus type 1
Inflammasomes
Inflammation
NLRP3
title_short Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression
title_full Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression
title_fullStr Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression
title_full_unstemmed Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression
title_sort Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression
dc.creator.fl_str_mv Marin Palma, Leidy Damariz
Castro G.A.
Cardona Arias, Jaiberth Antonio
Urcuqui-Inchima S.
Hernández López, Juan Carlos
dc.contributor.author.none.fl_str_mv Marin Palma, Leidy Damariz
Castro G.A.
Cardona Arias, Jaiberth Antonio
Urcuqui-Inchima S.
Hernández López, Juan Carlos
dc.subject.spa.fl_str_mv Acquired immunodeficiency syndrome
C-reactive protein
CD4+ T-cell count
High-density lipoproteins
Human immunodeficiency virus type 1
Inflammasomes
Inflammation
NLRP3
topic Acquired immunodeficiency syndrome
C-reactive protein
CD4+ T-cell count
High-density lipoproteins
Human immunodeficiency virus type 1
Inflammasomes
Inflammation
NLRP3
description Introduction: High-density lipoproteins (HDL) are responsible for the efflux and transport of cholesterol from peripheral tissues to the liver. In addition, HDL can modulate various immunological mechanisms, including the inflammatory response. Inflammasomes are multiprotein complexes that have been reported to be activated during human immunodeficiency virus type 1 (HIV-1) infection, thus contributing to immune hyperactivation, which is the main pathogenic mechanism of HIV-1 progression. However, the relationship between HDL and inflammasomes in the context of HIV-1 infection is unclear. Therefore, this research aims to explore the association between HDL and the components of the inflammatory response during HIV-1 infection. Methodology: A cross-sectional study, including 36 HIV-1-infected individuals without antiretroviral treatment and 36 healthy controls matched by sex and age, was conducted. Viral load, CD4+ T-cell counts, serum HDL, and C-reactive protein (CRP) were quantified. Serum cytokine levels, including IL-1ß, IL-6, and IL-18, were assessed by ELISA. The inflammasome-related genes in peripheral blood mononuclear cells were determined by quantitative real-time PCR. Results: HIV-1-infected individuals showed a significant decrease in HDL levels, particularly those subjects with higher viral load and lower CD4+ T-cell counts. Moreover, upregulation of inflammasome-related genes (NLRP3, AIM2, ASC, IL-1ß, and IL-18) was observed, notably in those HIV-1-infected individuals with higher viral loads (above 5,000 copies/mL). Serum levels of IL-6 and CRP were also elevated in HIV-1-infected individuals. Significant negative correlations between HDL and the mRNA of NLRP3, AIM2, ASC, IL-1ß, and IL-18, as well as viral load and CRP were observed in HIV-1-infected individuals. Likewise, a significant positive correlation between HDL and CD4+ T-cell counts was found. Conclusion: In summary, our results indicate that HDL might modulate the expression of several key components of the inflammasomes during HIV-1 infection, suggesting a novel role of HDL in modifying the inflammatory state and consequently, the progression of HIV-1 infection. © 2018 Marin-Palma, Castro, Cardona-Arias, Urcuqui-Inchima and Hernandez.
publishDate 2018
dc.date.issued.none.fl_str_mv 2018
dc.date.accessioned.none.fl_str_mv 2021-12-16T22:16:28Z
dc.date.available.none.fl_str_mv 2021-12-16T22:16:28Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
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dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.5281/zenodo.3740105
dc.identifier.issn.spa.fl_str_mv 16643224
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/42723
dc.identifier.bibliographicCitation.spa.fl_str_mv Marín D,Castro GA,Cardona JA,Urcuqui S,Hernandez JC. Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression. FRONT IMMUNOL. 2018. 9. 1350. .
url https://doi.org/10.5281/zenodo.3740105
https://hdl.handle.net/20.500.12494/42723
identifier_str_mv 16643224
Marín D,Castro GA,Cardona JA,Urcuqui S,Hernandez JC. Lower high-density lipoproteins levels during human immunodeficiency virus type 1 infection are associated with increased inflammatory markers and disease progression. FRONT IMMUNOL. 2018. 9. 1350. .
dc.relation.ispartofjournal.spa.fl_str_mv FRONT IMMUNOL
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
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dc.format.extent.spa.fl_str_mv -
dc.publisher.spa.fl_str_mv Frontiers Media S.A.
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
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