Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).

This study was addressed to determine the presence of Parkinson disease (PD) manifestations, their distribution according to motor subtypes, and the relationships with health-related quality of life (QoL) using the recently validated European Parkinson's Disease Association sponsored Parkinson&...

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Autores:
Balestrino, Roberta
Hurtado González, Carlos Alberto
Stocchi, Fabrizio
Radicati, Fabiana Giada
Chaudhuri, K. Ray
Rodriguez Blazquez, Carmen
Martínez Martin, Pablo
Pdcs European Study Group
Adarmes, Astrid D
Méndez Del Barrio, Carlota
Ariadne, Vakirli
Aschermann, Zsuzsanna
Juhász, Annamária
Harmat, Márk
Bostantjopoulou, Sevasti
Corbo, Massimo
Grassi, Andrea
Dellaporta, Dionysia
Falup Pecurariu, Cristian
Diaconu, Stefania
Giagkou, Nikolaos
Guekht, Alla
Popov, Georgy
Gurevich, Tanya
Johansson, Anders
Sundgren, Mathias
Kefalopoulou, Zinovia
Ellul, John
Kostic, Vladimir S
Kovacs, Norbert
Marti, Maria J
Planelles, Lluis
Migirov-Sanderovich, Angel
Ezra, Adi
Minar, Michal
Mir, Pablo
Necpal, Jan
Popovici, Maria
Simitsi, Athima
Stefanis, Leonidas
Simu, Mihaela
Rosca, Cecilia
Skorvanek, Matej
Stefani, Alessandro
Cerroni, Rocco
Stamelou, Maria
Tsolaki, Magda
Vuletic, Vladimira
Katsarou, Zoe
Tipo de recurso:
Article of journal
Fecha de publicación:
2019
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/41666
Acceso en línea:
https://doi.org/10.1371/journal.pone.0122569
https://hdl.handle.net/20.500.12494/41666
Palabra clave:
Epidemiology
Parkinson's disease
Rights
closedAccess
License
http://purl.org/coar/access_right/c_14cb
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oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/41666
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
dc.title.spa.fl_str_mv Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).
title Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).
spellingShingle Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).
Epidemiology
Parkinson's disease
title_short Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).
title_full Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).
title_fullStr Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).
title_full_unstemmed Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).
title_sort Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).
dc.creator.fl_str_mv Balestrino, Roberta
Hurtado González, Carlos Alberto
Stocchi, Fabrizio
Radicati, Fabiana Giada
Chaudhuri, K. Ray
Rodriguez Blazquez, Carmen
Martínez Martin, Pablo
Pdcs European Study Group
Adarmes, Astrid D
Méndez Del Barrio, Carlota
Ariadne, Vakirli
Aschermann, Zsuzsanna
Juhász, Annamária
Harmat, Márk
Bostantjopoulou, Sevasti
Corbo, Massimo
Grassi, Andrea
Dellaporta, Dionysia
Falup Pecurariu, Cristian
Diaconu, Stefania
Giagkou, Nikolaos
Guekht, Alla
Popov, Georgy
Gurevich, Tanya
Johansson, Anders
Sundgren, Mathias
Kefalopoulou, Zinovia
Ellul, John
Kostic, Vladimir S
Kovacs, Norbert
Marti, Maria J
Planelles, Lluis
Migirov-Sanderovich, Angel
Ezra, Adi
Minar, Michal
Mir, Pablo
Necpal, Jan
Popovici, Maria
Simitsi, Athima
Stefanis, Leonidas
Simu, Mihaela
Rosca, Cecilia
Skorvanek, Matej
Stefani, Alessandro
Cerroni, Rocco
Stamelou, Maria
Tsolaki, Magda
Vuletic, Vladimira
Katsarou, Zoe
dc.contributor.author.none.fl_str_mv Balestrino, Roberta
Hurtado González, Carlos Alberto
Stocchi, Fabrizio
Radicati, Fabiana Giada
Chaudhuri, K. Ray
Rodriguez Blazquez, Carmen
Martínez Martin, Pablo
Pdcs European Study Group
Adarmes, Astrid D
Méndez Del Barrio, Carlota
Ariadne, Vakirli
Aschermann, Zsuzsanna
Juhász, Annamária
Harmat, Márk
Bostantjopoulou, Sevasti
Corbo, Massimo
Grassi, Andrea
Dellaporta, Dionysia
Falup Pecurariu, Cristian
Diaconu, Stefania
Giagkou, Nikolaos
Guekht, Alla
Popov, Georgy
Gurevich, Tanya
Johansson, Anders
Sundgren, Mathias
Kefalopoulou, Zinovia
Ellul, John
Kostic, Vladimir S
Kovacs, Norbert
Marti, Maria J
Planelles, Lluis
Migirov-Sanderovich, Angel
Ezra, Adi
Minar, Michal
Mir, Pablo
Necpal, Jan
Popovici, Maria
Simitsi, Athima
Stefanis, Leonidas
Simu, Mihaela
Rosca, Cecilia
Skorvanek, Matej
Stefani, Alessandro
Cerroni, Rocco
Stamelou, Maria
Tsolaki, Magda
Vuletic, Vladimira
Katsarou, Zoe
dc.subject.spa.fl_str_mv Epidemiology
Parkinson's disease
topic Epidemiology
Parkinson's disease
description This study was addressed to determine the presence of Parkinson disease (PD) manifestations, their distribution according to motor subtypes, and the relationships with health-related quality of life (QoL) using the recently validated European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS). Frequency of symptoms was determined by the scores of items (present if >0). Using ROC analysis and Youden method, MDS-UPDRS motor subtypes were projected on the PDCS to achieve a comparable classification based on the PDCS scores. The same method was used to estimate severity levels from other measures in the study. The association between the PDCS and QoL (PDQ-39) was analyzed by correlation and multiple linear regression. The sample consisted of 776 PD patients. We found that the frequency of PD manifestations with PDCS and MDS-UPDRS were overlapping, the average difference between scales being 5.5% only. Using the MDS-UPDRS subtyping, 215 patients (27.7%) were assigned as Tremor Dominant (TD), 60 (7.7%) Indeterminate, and 501 (64.6%) Postural Instability and Gait Difficulty (PIGD) in this cohort. With this classification as criterion, the analogous PDCS-based ratio provided these cut-off values: TD subtype, =1.06; Indeterminate, <1.06 but >0.65; and PIGD, <0.65. The agreement between the two scales on this classification was substantial (87.6%; kappa = 0.69). PDCS total score cut-offs for PD severity were: 23/24 for mild/moderate and 41/42 for moderate/severe. Moderate to high correlations ( r = 0.35-0.80) between PDCS and PDQ-39 were obtained, and the four PDCS domains showed a significant independent influence on QoL. The conclusions are: (1) the PDCS assessed the frequency of PD symptoms analogous to the MDS-UPDRS; (2) motor subtypes and severity levels can be determined with the PDCS; (3) a significant association between PDCS and QoL scores exists.
publishDate 2019
dc.date.issued.none.fl_str_mv 2019
dc.date.accessioned.none.fl_str_mv 2021-12-16T22:15:41Z
dc.date.available.none.fl_str_mv 2021-12-16T22:15:41Z
dc.type.none.fl_str_mv Artículo
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dc.identifier.none.fl_str_mv https://doi.org/10.1371/journal.pone.0122569
dc.identifier.issn.spa.fl_str_mv 23738057
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/41666
dc.identifier.bibliographicCitation.spa.fl_str_mv Balestrino R,Hurtado CA,Stocchi F,Radicati FG,Chaudhuri KR,Rodriguez C,Martinez P,European Study Group PDCS,Adarmes AD,Méndez C,Ariadne V,Aschermann Z,Juhász A,Harmat M,Bostantjopoulou S,Corbo M,Grassi A,Dellaporta D,Falup C,Diaconu S,Giagkou N,Guekht A,Popov G,Gurevich T,Johansson A,Sundgren M,Kefalopoulou Z,Ellul J,Kostic VS,Kovacs N,Marti MJ,Planelles L,Migirov A,Ezra A,Minar M,Mir P,Necpal J,Popovici M,Simitsi A,Stefanis L,Simu M,Rosca C,Skorvanek M,Stefani A,Cerroni R,Stamelou M,Tsolaki M,Vuletic V,Katsarou Z. Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS). NPJ Parkinsons Dis. 2019. 5. (1):p. 26-26. .
url https://doi.org/10.1371/journal.pone.0122569
https://hdl.handle.net/20.500.12494/41666
identifier_str_mv 23738057
Balestrino R,Hurtado CA,Stocchi F,Radicati FG,Chaudhuri KR,Rodriguez C,Martinez P,European Study Group PDCS,Adarmes AD,Méndez C,Ariadne V,Aschermann Z,Juhász A,Harmat M,Bostantjopoulou S,Corbo M,Grassi A,Dellaporta D,Falup C,Diaconu S,Giagkou N,Guekht A,Popov G,Gurevich T,Johansson A,Sundgren M,Kefalopoulou Z,Ellul J,Kostic VS,Kovacs N,Marti MJ,Planelles L,Migirov A,Ezra A,Minar M,Mir P,Necpal J,Popovici M,Simitsi A,Stefanis L,Simu M,Rosca C,Skorvanek M,Stefani A,Cerroni R,Stamelou M,Tsolaki M,Vuletic V,Katsarou Z. Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS). NPJ Parkinsons Dis. 2019. 5. (1):p. 26-26. .
dc.relation.ispartofjournal.spa.fl_str_mv Npj Parkinson's Disease
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/closedAccess
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dc.format.extent.spa.fl_str_mv 26-26
dc.publisher.spa.fl_str_mv Nature Research
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
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spelling Balestrino, RobertaHurtado González, Carlos Alberto Stocchi, FabrizioRadicati, Fabiana GiadaChaudhuri, K. RayRodriguez Blazquez, CarmenMartínez Martin, PabloPdcs European Study GroupAdarmes, Astrid DMéndez Del Barrio, CarlotaAriadne, VakirliAschermann, ZsuzsannaJuhász, AnnamáriaHarmat, MárkBostantjopoulou, SevastiCorbo, MassimoGrassi, AndreaDellaporta, DionysiaFalup Pecurariu, CristianDiaconu, StefaniaGiagkou, NikolaosGuekht, AllaPopov, GeorgyGurevich, TanyaJohansson, AndersSundgren, MathiasKefalopoulou, ZinoviaEllul, JohnKostic, Vladimir SKovacs, NorbertMarti, Maria JPlanelles, LluisMigirov-Sanderovich, AngelEzra, AdiMinar, MichalMir, PabloNecpal, JanPopovici, MariaSimitsi, AthimaStefanis, LeonidasSimu, MihaelaRosca, CeciliaSkorvanek, MatejStefani, AlessandroCerroni, RoccoStamelou, MariaTsolaki, MagdaVuletic, VladimiraKatsarou, Zoe2021-12-16T22:15:41Z2021-12-16T22:15:41Z2019https://doi.org/10.1371/journal.pone.012256923738057https://hdl.handle.net/20.500.12494/41666Balestrino R,Hurtado CA,Stocchi F,Radicati FG,Chaudhuri KR,Rodriguez C,Martinez P,European Study Group PDCS,Adarmes AD,Méndez C,Ariadne V,Aschermann Z,Juhász A,Harmat M,Bostantjopoulou S,Corbo M,Grassi A,Dellaporta D,Falup C,Diaconu S,Giagkou N,Guekht A,Popov G,Gurevich T,Johansson A,Sundgren M,Kefalopoulou Z,Ellul J,Kostic VS,Kovacs N,Marti MJ,Planelles L,Migirov A,Ezra A,Minar M,Mir P,Necpal J,Popovici M,Simitsi A,Stefanis L,Simu M,Rosca C,Skorvanek M,Stefani A,Cerroni R,Stamelou M,Tsolaki M,Vuletic V,Katsarou Z. Applications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS). NPJ Parkinsons Dis. 2019. 5. (1):p. 26-26. .This study was addressed to determine the presence of Parkinson disease (PD) manifestations, their distribution according to motor subtypes, and the relationships with health-related quality of life (QoL) using the recently validated European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS). Frequency of symptoms was determined by the scores of items (present if >0). Using ROC analysis and Youden method, MDS-UPDRS motor subtypes were projected on the PDCS to achieve a comparable classification based on the PDCS scores. The same method was used to estimate severity levels from other measures in the study. The association between the PDCS and QoL (PDQ-39) was analyzed by correlation and multiple linear regression. The sample consisted of 776 PD patients. We found that the frequency of PD manifestations with PDCS and MDS-UPDRS were overlapping, the average difference between scales being 5.5% only. Using the MDS-UPDRS subtyping, 215 patients (27.7%) were assigned as Tremor Dominant (TD), 60 (7.7%) Indeterminate, and 501 (64.6%) Postural Instability and Gait Difficulty (PIGD) in this cohort. With this classification as criterion, the analogous PDCS-based ratio provided these cut-off values: TD subtype, =1.06; Indeterminate, <1.06 but >0.65; and PIGD, <0.65. The agreement between the two scales on this classification was substantial (87.6%; kappa = 0.69). PDCS total score cut-offs for PD severity were: 23/24 for mild/moderate and 41/42 for moderate/severe. Moderate to high correlations ( r = 0.35-0.80) between PDCS and PDQ-39 were obtained, and the four PDCS domains showed a significant independent influence on QoL. The conclusions are: (1) the PDCS assessed the frequency of PD symptoms analogous to the MDS-UPDRS; (2) motor subtypes and severity levels can be determined with the PDCS; (3) a significant association between PDCS and QoL scores exists.carlos.hurtadog@campusucc.edu.co26-26Nature ResearchEpidemiologyParkinson's diseaseApplications of the European Parkinson's Disease Association sponsored Parkinson's Disease Composite Scale (PDCS).Artículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionNpj Parkinson's Diseaseinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41666oai:repository.ucc.edu.co:20.500.12494/416662024-08-20 16:18:53.634metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com