Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis

Objective: The treatment of cutaneous leishmaniasis is toxic, has contraindications, and a high cost. The objective of this study was to estimate the cost-effectiveness of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. Methods: Effectiveness was the propor...

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Autores:
Cardona Arias, Jaiberth Antonio
López-Carvajal L.
Tamayo Plata M.P.
Vélez I.D.
Tipo de recurso:
Article of journal
Fecha de publicación:
2017
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/41760
Acceso en línea:
https://doi.org/10.15665/re.v14il1.675
https://hdl.handle.net/20.500.12494/41760
Palabra clave:
Antimony sodium gluconate
Colombia
cost-effectiveness analysis
cutaneous leishmaniasis
thermotherapy
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closedAccess
License
http://purl.org/coar/access_right/c_14cb
id COOPER2_0da927521d3667d5fd9214d099b1afa9
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/41760
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Cardona Arias, Jaiberth AntonioLópez-Carvajal L.Tamayo Plata M.P.Vélez I.D.2021-12-16T22:15:46Z2021-12-16T22:15:46Z2017https://doi.org/10.15665/re.v14il1.67517565383https://hdl.handle.net/20.500.12494/41760Cardona JA,López L,Tamayo MP,Vélez ID. Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. J. Evid.-Based Med. 2017. 10. (2):p. 81-90. .Objective: The treatment of cutaneous leishmaniasis is toxic, has contraindications, and a high cost. The objective of this study was to estimate the cost-effectiveness of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. Methods: Effectiveness was the proportion of healing and safety with the adverse effects; these parameters were estimated from a controlled clinical trial and a meta-analysis. A standard costing was conducted. Average and incremental cost-effectiveness ratios were estimated. The uncertainty regarding effectiveness, safety, and costs was determined through sensitivity analyses. Results: The total costs were $66,807 with Glucantime and $14,079 with thermotherapy. The therapeutic effectiveness rates were 64.2% for thermotherapy and 85.1% for Glucantime. The average cost-effectiveness ratios ranged between $721 and $1275 for Glucantime and between $187 and $390 for thermotherapy. Based on the meta-analysis, thermotherapy may be a dominant strategy. Conclusion: The excellent cost-effectiveness ratio of thermotherapy shows the relevance of its inclusion in guidelines for the treatment. © 2017 Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd0000-0002-7101-929Xjaiberth.cardona@campusucc.edu.co90-81Blackwell PublishingAntimony sodium gluconateColombiacost-effectiveness analysiscutaneous leishmaniasisthermotherapyCost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasisArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionJournal Of Evidence-Based Medicineinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41760oai:repository.ucc.edu.co:20.500.12494/417602024-08-20 16:23:22.808metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis
title Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis
spellingShingle Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis
Antimony sodium gluconate
Colombia
cost-effectiveness analysis
cutaneous leishmaniasis
thermotherapy
title_short Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis
title_full Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis
title_fullStr Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis
title_full_unstemmed Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis
title_sort Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis
dc.creator.fl_str_mv Cardona Arias, Jaiberth Antonio
López-Carvajal L.
Tamayo Plata M.P.
Vélez I.D.
dc.contributor.author.none.fl_str_mv Cardona Arias, Jaiberth Antonio
López-Carvajal L.
Tamayo Plata M.P.
Vélez I.D.
dc.subject.spa.fl_str_mv Antimony sodium gluconate
Colombia
cost-effectiveness analysis
cutaneous leishmaniasis
thermotherapy
topic Antimony sodium gluconate
Colombia
cost-effectiveness analysis
cutaneous leishmaniasis
thermotherapy
description Objective: The treatment of cutaneous leishmaniasis is toxic, has contraindications, and a high cost. The objective of this study was to estimate the cost-effectiveness of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. Methods: Effectiveness was the proportion of healing and safety with the adverse effects; these parameters were estimated from a controlled clinical trial and a meta-analysis. A standard costing was conducted. Average and incremental cost-effectiveness ratios were estimated. The uncertainty regarding effectiveness, safety, and costs was determined through sensitivity analyses. Results: The total costs were $66,807 with Glucantime and $14,079 with thermotherapy. The therapeutic effectiveness rates were 64.2% for thermotherapy and 85.1% for Glucantime. The average cost-effectiveness ratios ranged between $721 and $1275 for Glucantime and between $187 and $390 for thermotherapy. Based on the meta-analysis, thermotherapy may be a dominant strategy. Conclusion: The excellent cost-effectiveness ratio of thermotherapy shows the relevance of its inclusion in guidelines for the treatment. © 2017 Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd
publishDate 2017
dc.date.issued.none.fl_str_mv 2017
dc.date.accessioned.none.fl_str_mv 2021-12-16T22:15:46Z
dc.date.available.none.fl_str_mv 2021-12-16T22:15:46Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.15665/re.v14il1.675
dc.identifier.issn.spa.fl_str_mv 17565383
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/41760
dc.identifier.bibliographicCitation.spa.fl_str_mv Cardona JA,López L,Tamayo MP,Vélez ID. Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. J. Evid.-Based Med. 2017. 10. (2):p. 81-90. .
url https://doi.org/10.15665/re.v14il1.675
https://hdl.handle.net/20.500.12494/41760
identifier_str_mv 17565383
Cardona JA,López L,Tamayo MP,Vélez ID. Cost-effectiveness analysis of thermotherapy versus pentavalent antimonials for the treatment of cutaneous leishmaniasis. J. Evid.-Based Med. 2017. 10. (2):p. 81-90. .
dc.relation.ispartofjournal.spa.fl_str_mv Journal Of Evidence-Based Medicine
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_14cb
dc.format.extent.spa.fl_str_mv 90-81
dc.publisher.spa.fl_str_mv Blackwell Publishing
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
_version_ 1814247340632965120

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