Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control

Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion, and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on natural killer (NK) and CD4...

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Autores:
Taborda N.A.
Hernández López, Juan Carlos
Lajoie J.
Juno J.A.
Kimani J.
Rugeles M.T.
Fowke K.R.
Tipo de recurso:
Article of journal
Fecha de publicación:
2015
Institución:
Universidad Cooperativa de Colombia
Repositorio:
Repositorio UCC
Idioma:
OAI Identifier:
oai:repository.ucc.edu.co:20.500.12494/41727
Acceso en línea:
https://doi.org/10.15446/caldasia
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058989809&doi=10.1590%2f2175-35392018039914&partnerID=40&md5=88a8336d881068f7f4f579e9b1181159
https://hdl.handle.net/20.500.12494/41727
Palabra clave:
CD69 antigen
cytokine
gamma interferon inducible protein 10
lymphocyte activation gene 3 protein
programmed death 1 receptor
protein
protein TIM 3
Rights
closedAccess
License
http://purl.org/coar/access_right/c_14cb
id COOPER2_0a726b437e0d50791908c0c98cc9fbcb
oai_identifier_str oai:repository.ucc.edu.co:20.500.12494/41727
network_acronym_str COOPER2
network_name_str Repositorio UCC
repository_id_str
spelling Taborda N.A.Hernández López, Juan Carlos Lajoie J.Juno J.A.Kimani J.Rugeles M.T.Fowke K.R.2021-12-16T22:15:44Z2021-12-16T22:15:44Z2015https://doi.org/10.15446/caldasiahttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85058989809&doi=10.1590%2f2175-35392018039914&partnerID=40&md5=88a8336d881068f7f4f579e9b118115908892229https://hdl.handle.net/20.500.12494/41727Taborda NA,Hernández JC,Lajoie J,Juno JA,Kimani J,Rugeles MT,Fowke KR. Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control. AIDS Res Hum Retroviruses. 2015. 31. (6):p. 636-640. .Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion, and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on natural killer (NK) and CD4+ T cells and plasma levels of proinflammatory cytokines in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV controllers. There was lower expression of CD69, LAG-3, PD-1, and TIM-3 in both cohorts when compared to a low-risk population or HIV progressors. In addition, HIV controllers exhibited lower plasma levels of proinflamatory molecules TNF-a and IP-10. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion. © 2015 Mary Ann Liebert, Inc.0000-0002-9200-5698juanc.hernandezl@campusucc.edu.co640-636Mary Ann Liebert Inc.CD69 antigencytokinegamma interferon inducible protein 10lymphocyte activation gene 3 proteinprogrammed death 1 receptorproteinprotein TIM 3Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral controlArtículohttp://purl.org/coar/resource_type/c_6501http://purl.org/coar/resource_type/c_2df8fbb1http://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://purl.org/redcol/resource_type/ARTinfo:eu-repo/semantics/publishedVersionAIDS RES HUM RETROVinfo:eu-repo/semantics/closedAccesshttp://purl.org/coar/access_right/c_14cbPublication20.500.12494/41727oai:repository.ucc.edu.co:20.500.12494/417272024-08-20 16:20:12.817metadata.onlyhttps://repository.ucc.edu.coRepositorio Institucional Universidad Cooperativa de Colombiabdigital@metabiblioteca.com
dc.title.spa.fl_str_mv Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
title Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
spellingShingle Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
CD69 antigen
cytokine
gamma interferon inducible protein 10
lymphocyte activation gene 3 protein
programmed death 1 receptor
protein
protein TIM 3
title_short Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
title_full Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
title_fullStr Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
title_full_unstemmed Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
title_sort Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control
dc.creator.fl_str_mv Taborda N.A.
Hernández López, Juan Carlos
Lajoie J.
Juno J.A.
Kimani J.
Rugeles M.T.
Fowke K.R.
dc.contributor.author.none.fl_str_mv Taborda N.A.
Hernández López, Juan Carlos
Lajoie J.
Juno J.A.
Kimani J.
Rugeles M.T.
Fowke K.R.
dc.subject.spa.fl_str_mv CD69 antigen
cytokine
gamma interferon inducible protein 10
lymphocyte activation gene 3 protein
programmed death 1 receptor
protein
protein TIM 3
topic CD69 antigen
cytokine
gamma interferon inducible protein 10
lymphocyte activation gene 3 protein
programmed death 1 receptor
protein
protein TIM 3
description Chronic HIV-1 infection induces severe immune alterations, including hyperactivation, exhaustion, and apoptosis. In fact, viral control has been associated with low frequencies of these processes. Here, we evaluated the expression of activation and inhibitory molecules on natural killer (NK) and CD4+ T cells and plasma levels of proinflammatory cytokines in individuals exhibiting viral control: a cohort of HIV-1-exposed-seronegative individuals (HESN) and a cohort of HIV controllers. There was lower expression of CD69, LAG-3, PD-1, and TIM-3 in both cohorts when compared to a low-risk population or HIV progressors. In addition, HIV controllers exhibited lower plasma levels of proinflamatory molecules TNF-a and IP-10. These findings suggest that individuals exhibiting viral control have lower basal expression of markers associated with cellular activation and particularly immune exhaustion. © 2015 Mary Ann Liebert, Inc.
publishDate 2015
dc.date.issued.none.fl_str_mv 2015
dc.date.accessioned.none.fl_str_mv 2021-12-16T22:15:44Z
dc.date.available.none.fl_str_mv 2021-12-16T22:15:44Z
dc.type.none.fl_str_mv Artículo
dc.type.coar.fl_str_mv http://purl.org/coar/resource_type/c_2df8fbb1
dc.type.coar.none.fl_str_mv http://purl.org/coar/resource_type/c_6501
dc.type.coarversion.none.fl_str_mv http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/article
dc.type.redcol.none.fl_str_mv http://purl.org/redcol/resource_type/ART
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format http://purl.org/coar/resource_type/c_6501
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.15446/caldasia
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058989809&doi=10.1590%2f2175-35392018039914&partnerID=40&md5=88a8336d881068f7f4f579e9b1181159
dc.identifier.issn.spa.fl_str_mv 08892229
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12494/41727
dc.identifier.bibliographicCitation.spa.fl_str_mv Taborda NA,Hernández JC,Lajoie J,Juno JA,Kimani J,Rugeles MT,Fowke KR. Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control. AIDS Res Hum Retroviruses. 2015. 31. (6):p. 636-640. .
url https://doi.org/10.15446/caldasia
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85058989809&doi=10.1590%2f2175-35392018039914&partnerID=40&md5=88a8336d881068f7f4f579e9b1181159
https://hdl.handle.net/20.500.12494/41727
identifier_str_mv 08892229
Taborda NA,Hernández JC,Lajoie J,Juno JA,Kimani J,Rugeles MT,Fowke KR. Short communication: Low expression of activation and inhibitory molecules on NK cells and CD4+ T cells is associated with viral control. AIDS Res Hum Retroviruses. 2015. 31. (6):p. 636-640. .
dc.relation.ispartofjournal.spa.fl_str_mv AIDS RES HUM RETROV
dc.rights.accessrights.none.fl_str_mv info:eu-repo/semantics/closedAccess
dc.rights.coar.none.fl_str_mv http://purl.org/coar/access_right/c_14cb
eu_rights_str_mv closedAccess
rights_invalid_str_mv http://purl.org/coar/access_right/c_14cb
dc.format.extent.spa.fl_str_mv 640-636
dc.publisher.spa.fl_str_mv Mary Ann Liebert Inc.
institution Universidad Cooperativa de Colombia
repository.name.fl_str_mv Repositorio Institucional Universidad Cooperativa de Colombia
repository.mail.fl_str_mv bdigital@metabiblioteca.com
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