Desarrollo y escalamiento de bioplaguicidas

Como se mostró en el capítulo anterior, el desarrollo tecnológico de un bioplaguicida inicia con la etapa de prueba, la cual enmarca una serie de actividades e iniciativas de carácter investigativo y experimental para generar una línea base apropiada para la aplicación de las etapas posteriores. En...

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Autores:: Díaz García, Andrés
Gómez Álvarez, Martha Isabel
Grijalba Bernal, Erika Paola
Santos Diaz, Adriana Marcela
Cruz Barrera, Fredy Mauricio
León Moreno, Diana Marcela
Alarcón Torres, Érika Andrea
Cotes Prado, Alba Marina

Tipo de recurso:: Part of book

Fecha de publicación:: 2018

Institución:: Agrosavia

Repositorio:: Agrosavia

Idioma:: spa

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network_acronym_str	Agrosavia2
network_name_str	Agrosavia
repository_id_str
dc.title.spa.fl_str_mv	Desarrollo y escalamiento de bioplaguicidas
dc.title.translated.eng.fl_str_mv	Development and scaling of biopesticides
title	Desarrollo y escalamiento de bioplaguicidas
spellingShingle	Desarrollo y escalamiento de bioplaguicidas Protección de plantas aspectos generales - H01 Bioplaguicidas Fermentación Formulaciones Transferencia de tecnología Transversal
title_short	Desarrollo y escalamiento de bioplaguicidas
title_full	Desarrollo y escalamiento de bioplaguicidas
title_fullStr	Desarrollo y escalamiento de bioplaguicidas
title_full_unstemmed	Desarrollo y escalamiento de bioplaguicidas
title_sort	Desarrollo y escalamiento de bioplaguicidas
dc.creator.fl_str_mv	Díaz García, Andrés Gómez Álvarez, Martha Isabel Grijalba Bernal, Erika Paola Santos Diaz, Adriana Marcela Cruz Barrera, Fredy Mauricio León Moreno, Diana Marcela Alarcón Torres, Érika Andrea Cotes Prado, Alba Marina
dc.contributor.author.none.fl_str_mv	Díaz García, Andrés Gómez Álvarez, Martha Isabel Grijalba Bernal, Erika Paola Santos Diaz, Adriana Marcela Cruz Barrera, Fredy Mauricio León Moreno, Diana Marcela Alarcón Torres, Érika Andrea Cotes Prado, Alba Marina
dc.subject.fao.spa.fl_str_mv	Protección de plantas aspectos generales - H01
topic	Protección de plantas aspectos generales - H01 Bioplaguicidas Fermentación Formulaciones Transferencia de tecnología Transversal
dc.subject.agrovoc.spa.fl_str_mv	Bioplaguicidas Fermentación Formulaciones Transferencia de tecnología
dc.subject.red.spa.fl_str_mv	Transversal
description	Como se mostró en el capítulo anterior, el desarrollo tecnológico de un bioplaguicida inicia con la etapa de prueba, la cual enmarca una serie de actividades e iniciativas de carácter investigativo y experimental para generar una línea base apropiada para la aplicación de las etapas posteriores. En el presente capítulo se exponen con detalle las etapas de desarrollo, escalamiento piloto, registro y transferencia de la tecnología, que permitirán la implementación exitosa de un bioplaguicida. Inicialmente se debe acopiar, analizar y hacer una primera toma de decisiones sobre los candidatos o aislamientos más apropiados, a partir de la información generada por los estudios de vigilancia tecnológica y prefactibilidad (basados en una posible opción de negocio preliminar). En la etapa de desarrollo se selecciona el tipo de fermentación, se termina el diseño del medio de cultivo, se realizan las pruebas de compatibilidad con agroquímicos, se estandarizan los métodos de control de calidad, se determina la estabilidad en almacenamiento de los prototipos de formulación y su eficacia, y se define el modelo de negocios y el potencial de mercado. En la etapa de escalamiento piloto se optimiza el medio de cultivo, se realiza el escalamiento tanto de la producción masiva por fermentación como de la formulación, se calculan los costos de producción y se implementan estrategias de mercadeo. En la última etapa, se lleva a cabo el registro del producto, la transferencia de la tecnología y la implementación del modelo de negocios. La suma de todas estas actividades implica que el desarrollo tecnológico de un bioplaguicida se considere como una tecnología de mediano plazo (entre 4 y 5 años), que requiere de una inversión de alto costo. La aplicación de las etapas mencionadas requiere de una organización robusta y eficiente, a cargo de un personal multidisciplinario (idóneo para el uso efectivo de recursos logísticos y técnicos; para el manejo de información experimental, económica y legal; y para la gestión administrativa), capaz de abordar todos los retos asociados a la optimización, escalamiento y registro de bioplaguicidas en Colombia.
publishDate	2018
dc.date.accessioned.none.fl_str_mv	2018-12-04T15:57:27Z
dc.date.available.none.fl_str_mv	2018-12-04T15:57:27Z
dc.date.issued.none.fl_str_mv	2018
dc.type.localeng.eng.fl_str_mv	book part
dc.type.local.spa.fl_str_mv	Capítulo
dc.type.coar.none.fl_str_mv	http://purl.org/coar/resource_type/c_3248
dc.type.driver.none.fl_str_mv	info:eu-repo/semantics/bookPart
dc.type.redcol.none.fl_str_mv	https://purl.org/redcol/resource_type/CAP_LIB
dc.type.version.none.fl_str_mv	http://purl.org/coar/version/c_970fb48d4fbd8a85
format	http://purl.org/coar/resource_type/c_3248
dc.identifier.isbn.none.fl_str_mv	978-958-740-254-4 (e-book)
dc.identifier.uri.none.fl_str_mv	http://hdl.handle.net/20.500.12324/34077
dc.identifier.reponame.spa.fl_str_mv	reponame:Biblioteca Digital Agropecuaria de Colombia
dc.identifier.repourl.none.fl_str_mv	repourl:https://repository.agrosavia.co
dc.identifier.instname.spa.fl_str_mv	instname:Corporación colombiana de investigación agropecuaria AGROSAVIA
identifier_str_mv	978-958-740-254-4 (e-book) reponame:Biblioteca Digital Agropecuaria de Colombia repourl:https://repository.agrosavia.co instname:Corporación colombiana de investigación agropecuaria AGROSAVIA
url	http://hdl.handle.net/20.500.12324/34077
dc.language.iso.none.fl_str_mv	spa
language	spa
dc.relation.citationstartpage.none.fl_str_mv	628
dc.relation.citationendpage.none.fl_str_mv	691
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dc.relation.ispartofbook.spa.fl_str_mv	33519 ; Control biológico de fitopatógenos, insectos y ácaros: Aplicaciones y perspectivas V. 2.
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spelling	Díaz García, Andrés25b799bc-a666-421d-b623-a9bc50c93442600Gómez Álvarez, Martha Isabeld0c88b32-c985-46ee-ba78-1b0cb4c5c54d600Grijalba Bernal, Erika Paola265afe95-177b-41f2-b3b4-cb8a9571c2d6600Santos Diaz, Adriana Marcela54510971-c605-48ce-ae06-0523a15bd233600Cruz Barrera, Fredy Mauriciofed73780-e7dc-4b93-b93a-ec6003cce5b1600León Moreno, Diana Marcelae5248fa7-e982-4f36-b867-1cbd4b9675e3600Alarcón Torres, Érika Andrea416465a0-e65b-4c98-a292-257c8bed4bb8600Cotes Prado, Alba Marina04c5bf5c-d798-4ac4-9bbe-51fb1e3760786002018-12-04T15:57:27Z2018-12-04T15:57:27Z2018978-958-740-254-4 (e-book)http://hdl.handle.net/20.500.12324/34077reponame:Biblioteca Digital Agropecuaria de Colombiarepourl:https://repository.agrosavia.coinstname:Corporación colombiana de investigación agropecuaria AGROSAVIAComo se mostró en el capítulo anterior, el desarrollo tecnológico de un bioplaguicida inicia con la etapa de prueba, la cual enmarca una serie de actividades e iniciativas de carácter investigativo y experimental para generar una línea base apropiada para la aplicación de las etapas posteriores. En el presente capítulo se exponen con detalle las etapas de desarrollo, escalamiento piloto, registro y transferencia de la tecnología, que permitirán la implementación exitosa de un bioplaguicida. Inicialmente se debe acopiar, analizar y hacer una primera toma de decisiones sobre los candidatos o aislamientos más apropiados, a partir de la información generada por los estudios de vigilancia tecnológica y prefactibilidad (basados en una posible opción de negocio preliminar). En la etapa de desarrollo se selecciona el tipo de fermentación, se termina el diseño del medio de cultivo, se realizan las pruebas de compatibilidad con agroquímicos, se estandarizan los métodos de control de calidad, se determina la estabilidad en almacenamiento de los prototipos de formulación y su eficacia, y se define el modelo de negocios y el potencial de mercado. En la etapa de escalamiento piloto se optimiza el medio de cultivo, se realiza el escalamiento tanto de la producción masiva por fermentación como de la formulación, se calculan los costos de producción y se implementan estrategias de mercadeo. En la última etapa, se lleva a cabo el registro del producto, la transferencia de la tecnología y la implementación del modelo de negocios. La suma de todas estas actividades implica que el desarrollo tecnológico de un bioplaguicida se considere como una tecnología de mediano plazo (entre 4 y 5 años), que requiere de una inversión de alto costo. La aplicación de las etapas mencionadas requiere de una organización robusta y eficiente, a cargo de un personal multidisciplinario (idóneo para el uso efectivo de recursos logísticos y técnicos; para el manejo de información experimental, económica y legal; y para la gestión administrativa), capaz de abordar todos los retos asociados a la optimización, escalamiento y registro de bioplaguicidas en Colombia.application/pdfspa‎‎Corporación colombiana de investigación agropecuaria - AGROSAVIABogotá (Colombia)Attribution-NonCommercial-ShareAlike 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-sa/4.0/http://purl.org/coar/access_right/c_abf2Desarrollo y escalamiento de bioplaguicidasDevelopment and scaling of biopesticidesProtección de plantas aspectos generales - H01BioplaguicidasFermentaciónFormulacionesTransferencia de tecnologíaTransversalTécnicoProfesionalInvestigadorCientíficobook partCapítulohttp://purl.org/coar/resource_type/c_3248info:eu-repo/semantics/bookParthttps://purl.org/redcol/resource_type/CAP_LIBhttp://purl.org/coar/version/c_970fb48d4fbd8a85Colombia628691Abadias, M., Usall, J., Teixidó, N., & Viñas, I. (2003). Liquid formulation of the postharvest biocontrol agent Candida sake CPA-1 in isotonic solutions. Phytopathology, 93(4), 436-442. doi:10.1094/PHYTO.2003.93.4.436.Abot, A., Moscardi, F., Fuxa, J., Sosa-Gómez, D., & Richter, A. (1996). Development of resistance by Anticarsia gemmatalis from Brazil and the United States to a nuclear Polyhedrosis virus under laboratory selection pressure. Biological Control, 7(1), 126-130. doi:10.1006/ bcon.1996.0075.Adinarayana, K., & Ellaiah, P. (2002). Response surface optimization of the critical medium components for the production of alkaline protease by a newly isolated Bacillus sp. Journal of Pharmacy & Pharmaceutical Sciences, 5(3), 272-278.Aggarwal, A., & Singh, H. (2005). Optimization of machining techniques - A retrospective and literature review. Sadhana, 30(6), 699-711.Aguilera, A. A. (2014). Vigilancia Tecnológica. Recuperado de http://huila.gov.co/documentos/V/vigilancia_ tecnologica_pioridades.pdfAl-Hamdani, A., & Cooke, R. (1987). Effects of water potential on accumulation and exudation of carbohydrates and glycerol during sclerotium formation and myceliogenic germination in Sclerotinia sclerotiorum. Transactions of the British Mycological Society, 89(1), 51-60. doi:10.1016/ S0007-1536(87)80057-8.Aldasoro Alustiza, J. C., Cantonnet Jordi, M. L., & Cilleruelo Carrasco, E. (2012). La vigilancia tecnológica y la inteligencia competitiva en los estándares de gestión de la calidad en I+D+i. Recuperado de http://adingor.es/ congresos/web/uploads/cio/cio2012/SP_04_Gestion_ Innovacion_Tecnolo g ica_y_Organiz ativa/1162- 1168.pdf.Álvarez, F., Castro, M., Príncipe, A., Borioli, G., Fischer, S., Mori, G., & Jofre, E. (2012). The plant-associated Bacillus amyloliquefaciens strains MEP218 and ARP23 capable of producing the cyclic lipopeptides iturin or surfactin and fengycin are effective in biocontrol of Sclerotinia stem rot disease. 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Bioresource Technology, 102(7), 4820-4826. doi:10.1016/j.biortech.2010.12.098.33519 ; Control biológico de fitopatógenos, insectos y ácaros: Aplicaciones y perspectivas V. 2.LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://repository.agrosavia.co/bitstream/20.500.12324/34077/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52open accessORIGINALVer_Documento_34077.pdfVer_Documento_34077.pdfapplication/pdf2913429https://repository.agrosavia.co/bitstream/20.500.12324/34077/5/Ver_Documento_34077.pdf7e30b3cb80cdd0cef2ec8355b66c0f16MD55open accessTHUMBNAILVer_Documento_34077.pdf.jpgVer_Documento_34077.pdf.jpgimage/jpeg24763https://repository.agrosavia.co/bitstream/20.500.12324/34077/6/Ver_Documento_34077.pdf.jpg8de8f185c856030b6152c033f17e945bMD56open access20.500.12324/34077oai:repository.agrosavia.co:20.500.12324/340772024-09-19 10:03:32.138open accessAgrosavia - Corporación colombiana de investigación agropecuariabac@agrosavia.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